Drug-Induced Liver Injury: Highlights from a Review of the 2015 Literature

Herbal hepatotoxicity: Challenges and pitfalls of causality assessment methods

(2017) Rolf Teschke et al.   WORLD JOURNAL OF GASTROENTEROLOGY

N-acetylcysteine for non-paracetamol drug-induced liver injury: a systematic review

(2016) Mohamed Farouk Chughlay et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Risk Factors, Clinical Presentation, and Outcomes in Overdose With Acetaminophen Alone or With Combination Products

(2016) Marina Serper et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Methylprednisolone-induced liver injury: Case report and literature review

(2016) Yana Davidov et al.   Journal of Digestive Diseases

Albumin Dialysis for Liver Failure: A Systematic Review

(2015) Evangelos Tsipotis et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

New onset idiosyncratic liver enzyme elevations with biological therapy in inflammatory bowel disease

(2015) E. Shelton et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Persistent Liver Biochemistry Abnormalities Are More Common in Older Patients and those With Cholestatic Drug Induced Liver Injury

(2015) Robert J Fontana et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The mystery of the Hawaii liver disease cluster in summer 2013: A pragmatic and clinical approach to solve the problem

(2015) Rolf Teschke et al.   Annals of Hepatology

Grazoprevir–Elbasvir Combination Therapy for Treatment-Naive Cirrhotic and Noncirrhotic Patients With Chronic Hepatitis C Virus Genotype 1, 4, or 6 Infection

(2015) Stefan Zeuzem et al.   ANNALS OF INTERNAL MEDICINE

Hepatic decompensation with sofosbuvir plus simeprevir in a patient with Child-Pugh B compensated cirrhosis

(2015) Vincent Soriano et al.   ANTIVIRAL THERAPY

Hepatotoxicity of herbal and dietary supplements: an update

(2015) Felix Stickel et al.   ARCHIVES OF TOXICOLOGY

Use of apixaban after development of suspected rivaroxaban-induced hepatic steatosis; a case report

(2015) Emily J. Anastasia et al.   BLOOD COAGULATION & FIBRINOLYSIS

A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury

(2015) Chote Luangchosiri et al.   BMC Complementary and Alternative Medicine

Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis

(2015) Anne Bertrand et al.   BMC Medicine

Liver injury with novel oral anticoagulants: assessing post-marketing reports in the US Food and Drug Administration adverse event reporting system

(2015) Emanuel Raschi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Liver transplant associated with paracetamol overdose: results from the seven-country SALT study

(2015) Sinem Ezgi Gulmez et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Drug-induced liver injury: results from the hospital-based Berlin Case-Control Surveillance Study

(2015) Antonios Douros et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition

(2015) Nathalie Bergeron et al.   CIRCULATION

Drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome: clinical features of 27 patients

(2015) J. Avancini et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Comparative analysis of portal hepatic infiltrating leucocytes in acute drug-induced liver injury, idiopathic autoimmune and viral hepatitis

(2015) D. M. Foureau et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Risk of Acute Liver Failure in Patients With Drug-Induced Liver Injury: Evaluation of Hy’s Law and a New Prognostic Model

(2015) Vincent Lo Re et al.   Clinical Gastroenterology and Hepatology

Identification and Characterization of Cefazolin-Induced Liver Injury

(2015) Saleh A. Alqahtani et al.   Clinical Gastroenterology and Hepatology

Under-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid Hepatotoxicity

(2015) Paul H. Hayashi et al.   Clinical Gastroenterology and Hepatology

Clinical and Histologic Features of Azithromycin-Induced Liver Injury

(2015) Melissa A. Martinez et al.   Clinical Gastroenterology and Hepatology

The Art and Science of Diagnosing and Managing Drug-induced Liver Injury in 2015 and Beyond

(2015) James H. Lewis   Clinical Gastroenterology and Hepatology

Blood alanine aminotransferase levels >1,000 IU/l - causes and outcomes

(2015) Z. Galvin et al.   CLINICAL MEDICINE

Can AST/ALT ratio indicate recovery after acute paracetamol poisoning?

(2015) Allison J. McGovern et al.   CLINICAL TOXICOLOGY

Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database

(2015) Paul B. Watkins et al.   DRUG SAFETY

Hepatotoxicity of New Oral Anticoagulants (NOACs)

(2015) Evangelia Liakoni et al.   DRUG SAFETY

Hepatotoxicity Associated with the Use of Anti-TNF-α Agents

(2015) Joshua B. French et al.   DRUG SAFETY

Hepatotoxicity associated with the dietary supplement OxyELITE Pro™ - Hawaii, 2013

(2015) David I. Johnston et al.   Drug Testing and Analysis

Systematic review on herb-induced liver injury in Korea

(2015) Woo-Jin Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Population-Representative Incidence of Drug-Induced Acute Liver Failure Based on an Analysis of an Integrated Health Care System

(2015) David S. Goldberg et al.   GASTROENTEROLOGY

CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure

(2015) Benjamin M. Stutchfield et al.   GASTROENTEROLOGY

Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study

(2015) Naga Chalasani et al.   GASTROENTEROLOGY

Causes, Features, and Outcomes of Drug-Induced Liver Injury in 69 Children from China

(2015) Yun Zhu et al.   Gut and Liver

Severe hepatotoxicity associated with asunaprevir and daclatasvir in chronic hepatitis C

(2015) Soichiro Shibata et al.   HEPATOLOGY

Categorization of drugs implicated in causing liver injury: Critical assessment based on published case reports

(2015) Einar S. Björnsson et al.   HEPATOLOGY

Drug-induced liver injury associated with stevens-Johnson syndrome/toxic epidermal necrolysis: Patient characteristics, causes, and outcome in 36 cases

(2015) Harshad Devarbhavi et al.   HEPATOLOGY

Natural history and outcomes in drug-induced autoimmune hepatitis

(2015) Tian T. Yeong et al.   HEPATOLOGY RESEARCH

Drug-induced liver injury in a chronic hepatitis C patient treated by peginterferon, ribavirin and simeprevir

(2015) Akira Okajima et al.   HEPATOLOGY RESEARCH

Drug-Induced Liver Injury during Antidepressant Treatment: Results of AMSP, a Drug Surveillance Program

(2015) Michaela-Elena Friedrich et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Hepatotoxicity associated with agomelatine and other antidepressants: Disproportionality analysis using pooled pharmacovigilance data from the Uppsala Monitoring Centre

(2015) Maximilian Gahr et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Ipilimumab-induced toxicities and the gastroenterologist

(2015) Robert Cheng et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study

(2015) Karla C.L. Lee et al.   JOURNAL OF HEPATOLOGY

Drug-induced liver injury: Interactions between drug properties and host factors

(2015) Minjun Chen et al.   JOURNAL OF HEPATOLOGY

Liver injury in patients with DRESS: A clinical study of 72 cases

(2015) I-Chun Lin et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial

(2015) Frederick J Raal et al.   LANCET

PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial

(2015) Frederick J Raal et al.   LANCET

Cyproterone acetate induces a wide spectrum of acute liver damage including corticosteroid-responsive hepatitis: report of 22 cases

(2015) Fernando Bessone et al.   LIVER INTERNATIONAL

Pharmacogenetic testing in idiosyncratic drug-induced liver injury: current role in clinical practice

(2015) Guruprasad P. Aithal   LIVER INTERNATIONAL

Use of Pediatric Health Information System database to study the trends in the incidence, management, etiology, and outcomes due to pediatric acute liver failure in the United States from 2008 to 2013

(2015) Sakil Kulkarni et al.   PEDIATRIC TRANSPLANTATION

The Role of Adverse Event Reporting in the FDA Response to a Multistate Outbreak of Liver Disease Associated with a Dietary Supplement

(2015) Karl C. Klontz et al.   PUBLIC HEALTH REPORTS

Continuous molecular adsorbent recirculating system treatment in 69 patients listed for liver transplantation

(2015) Per Olin et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Model for end-stage liver disease score as a predictor of short-term outcome in patients with drug-induced liver injury

(2015) Rubi Jeong et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children

(2015) Xi Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Viral hepatitis prevalence in patients with active and latent tuberculosis

(2015) Hesam Ahmadi Nooredinvand   WORLD JOURNAL OF GASTROENTEROLOGY

Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy: A single center report of 8 cases

(2015) Susana Rodrigues   WORLD JOURNAL OF GASTROENTEROLOGY

Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury

(2015) A. D. B. Vliegenthart et al.   Scientific Reports

Paracetamol overdose in Hong Kong: is the 150-treatment line good enough to cover patients with paracetamol-induced liver injury?

(2015) Simon TB Chan et al.   HONG KONG MEDICAL JOURNAL

MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury

(2015) Mitchell McGill et al.   Journal of Clinical Medicine

The Possible Mechanism of Idiosyncratic Lapatinib-Induced Liver Injury in Patients Carrying Human Leukocyte Antigen-DRB1*07:01

(2015) Makoto Hirasawa et al.   PLoS One

Review article: herbal hepatotoxicity - an update on traditional Chinese medicine preparations

(2014) R. Teschke et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Outbreak of Severe Hepatitis Linked to Weight-Loss Supplement OxyELITE Pro

(2014) Marina M Roytman et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury

(2014) Naga P Chalasani et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

miRNAs and their application in drug-induced liver injury

(2014) Yuping Wang et al.   Biomarkers in Medicine

Hepatic Decompensation Likely Attributable to Simeprevir in Patients with Advanced Cirrhosis

(2014) Jonathan G. Stine et al.   DIGESTIVE DISEASES AND SCIENCES

Experience with OxyELITE Pro and Acute Liver Injury in Active Duty Service Members

(2014) Sean Foley et al.   DIGESTIVE DISEASES AND SCIENCES

Evolution of the Food and Drug Administration Approach to Liver Safety Assessment for New Drugs: Current Status and Challenges

(2014) John R. Senior   DRUG SAFETY

Liver Safety Assessment in Special Populations (Hepatitis B, C, and Oncology Trials)

(2014) Gerd A. Kullak-Ublick et al.   DRUG SAFETY

Methylprednisolone-induced hepatotoxicity: experiences from global adverse drug reaction surveillance

(2014) Ola Caster et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients

(2014) Mitchell R McGill et al.   Expert Opinion on Drug Metabolism & Toxicology

Human leukocyte antigen genetic risk factors of drug-induced liver toxicology

(2014) Jane I Grove et al.   Expert Opinion on Drug Metabolism & Toxicology

Use of Hy's Law and a New Composite Algorithm to Predict Acute Liver Failure in Patients With Drug-Induced Liver Injury

(2014) Mercedes Robles–Diaz et al.   GASTROENTEROLOGY

Idiosyncratic Drug-Induced Liver Injury Is Associated With Substantial Morbidity and Mortality Within 6 Months From Onset

(2014) Robert J. Fontana et al.   GASTROENTEROLOGY

Drug-induced immunoallergic hepatitis during combination therapy with daclatasvir and asunaprevir

(2014) Yohei Fujii et al.   HEPATOLOGY

Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network

(2014) Victor J. Navarro et al.   HEPATOLOGY

Liver dialysis in acute-on-chronic liver failure: current and future perspectives

(2014) Rakhi Maiwall et al.   Hepatology International

The association betweenHLA-DQB1polymorphism and antituberculosis drug-induced liver injury: a Case-Control Study

(2014) R. Chen et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Rivaroxaban postmarketing risk of liver injury

(2014) Stefan Russmann et al.   JOURNAL OF HEPATOLOGY

Two-year outcomes in initial survivors with acute liver failure: results from a prospective, multicentre study

(2014) Robert J. Fontana et al.   LIVER INTERNATIONAL

Reliability of causality assessment for drug, herbal and dietary supplement hepatotoxicity in the Drug-Induced Liver Injury Network (DILIN)

(2014) Paul H. Hayashi et al.   LIVER INTERNATIONAL

The role of intestinal microbiota in murine models of acetaminophen-induced hepatotoxicity

(2014) Lucia A Possamai et al.   LIVER INTERNATIONAL

Eculizumab hepatotoxicity in pediatric aHUS

(2014) Wesley Hayes et al.   PEDIATRIC NEPHROLOGY

Future of pharmacogenetics-based therapy for tuberculosis

(2014) Tomoshige Matsumoto et al.   PHARMACOGENOMICS

Association study of UGT1A9 promoter polymorphisms with DILI based on systematically regional variation screen in Chinese population

(2014) J Jiang et al.   PHARMACOGENOMICS JOURNAL

Severe Ductopenia and Cholestasis from Levofloxacin Drug-Induced Liver Injury: A Case Report and Review

(2014) Anshu Trivedi et al.   SEMINARS IN LIVER DISEASE

Genetic Basis of Drug-Induced Liver Injury: Present and Future

(2014) Thomas Urban et al.   SEMINARS IN LIVER DISEASE

Hepatotoxicity Induced by Herbal and Dietary Supplements

(2014) M. Lucena et al.   SEMINARS IN LIVER DISEASE

Estimating heritability of drug-induced liver injury from common variants and implications for future study designs

(2014) Casey Lynnette Overby et al.   Scientific Reports

Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges

(2014) James W Dear et al.   Expert Review of Clinical Pharmacology

Liver Injury From Tumor Necrosis Factor-α Antagonists: Analysis of Thirty-four Cases

(2013) Marwan Ghabril et al.   Clinical Gastroenterology and Hepatology

Drug-induced Acute Liver Failure

(2013) William M. Lee   Clinics in Liver Disease

Catechins in Dietary Supplements and Hepatotoxicity

(2013) Victor J. Navarro et al.   DIGESTIVE DISEASES AND SCIENCES

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

Flow Cytometry Analysis with a New FITC-Conjugated Monoclonal Antibody-3E12 for HLA-B*57:01 Rapid Screening in Prevention of Abacavir Hypersensitivity in HIV-1–Infected Patients

(2013) C. Rodríguez-Sáinz et al.   HIV CLINICAL TRIALS

Characteristics of liver injury in drug-induced systemic hypersensitivity reactions

(2013) Taehoon Lee et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts

(2013) Petra Thulin et al.   LIVER INTERNATIONAL

New biomarkers for drug-induced liver injury: are they really better? what do they diagnose?

(2013) John R. Senior   LIVER INTERNATIONAL

HLA Alleles Influence the Clinical Signature of Amoxicillin-Clavulanate Hepatotoxicity

(2013) Camilla Stephens et al.   PLoS One

Long term effect of reduced pack sizes of paracetamol on poisoning deaths and liver transplant activity in England and Wales: interrupted time series analyses

(2013) K. Hawton et al.   BMJ-British Medical Journal

Clinical Perspective: Statins and the Liver—Harmful or Helpful?

(2012) James H. Lewis   DIGESTIVE DISEASES AND SCIENCES

Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: A placebo-controlled clinical trial

(2012) Robert H. Squires et al.   HEPATOLOGY

High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury

(2012) Minjun Chen et al.   HEPATOLOGY

Outcome and determinants of mortality in 269 patients with combination anti-tuberculosis drug-induced liver injury

(2012) Harshad Devarbhavi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The PCSK9 decade

(2012) Gilles Lambert et al.   JOURNAL OF LIPID RESEARCH

Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study

(2012) Marina Cuchel et al.   LANCET

Clinical and Histopathologic Features of Fluoroquinolone-Induced Liver Injury

(2011) Eric S. Orman et al.   Clinical Gastroenterology and Hepatology

Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury

(2011) Timothy J. Davern et al.   GASTROENTEROLOGY

Drug-induced acute liver failure: Results of a U.S. multicenter, prospective study

(2010) Adrian Reuben et al.   HEPATOLOGY

Drug-induced autoimmune hepatitis: Clinical characteristics and prognosis

(2010) Einar Björnsson et al.   HEPATOLOGY

Drug-Induced Liver Injury Network (DILIN) Prospective Study

(2009) Robert J. Fontana et al.   DRUG SAFETY

Intravenous N-Acetylcysteine Improves Transplant-Free Survival in Early Stage Non-Acetaminophen Acute Liver Failure

(2009) William M. Lee et al.   GASTROENTEROLOGY

Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events

(2009) Craig Lammert et al.   HEPATOLOGY

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS