Human leukocyte antigen genetic risk factors of drug-induced liver toxicology

HLA Class I restricted CD8+ and Class II restricted CD4+ T cells are implicated in the pathogenesis of nevirapine hypersensitivity

(2014) Niamh M. Keane et al.   AIDS

T Cells Infiltrate the Liver and Kill Hepatocytes in HLA-B ∗ 57:01-Associated Floxacillin-Induced Liver Injury

(2014) Natascha Wuillemin et al.   AMERICAN JOURNAL OF PATHOLOGY

Genotyping for Severe Drug Hypersensitivity

(2014) Eric Karlin et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Human Leukocyte Antigen (HLA) Pharmacogenomic Tests: Potential and Pitfalls

(2014) Ann Daly   CURRENT DRUG METABOLISM

Prospective Validation ofHLA-DRB1*07:01Allele Carriage As a Predictive Risk Factor for Lapatinib-Induced Liver Injury

(2014) Daniel J. Schaid et al.   JOURNAL OF CLINICAL ONCOLOGY

Genetic Basis of Drug-Induced Liver Injury: Present and Future

(2014) Thomas Urban et al.   SEMINARS IN LIVER DISEASE

Pharmacogenomics: Current State-of-the-Art

(2014) Daniel Carr et al.   Genes

HLA Associations and Clinical Implications in T-Cell Mediated Drug Hypersensitivity Reactions: An Updated Review

(2014) Chi-Yuan Cheng et al.   Journal of Immunology Research

Identification of susceptible HLA class II co-amoxiclav genotypes based on the analysis of drug-specific T-cells from patients with liver injury

(2014) Katy Saide et al.   Clinical and Translational Allergy

Consequences of drug binding to immune receptors: Immune stimulation following pharmacological interaction with immune receptors (T-cell receptor for antigen or human leukocyte antigen) with altered peptide-human leukocyte antigen or peptide

(2013) Werner J. Pichler   Dermatologica Sinica

Incidence, Presentation, and Outcomes in Patients With Drug-Induced Liver Injury in the General Population of Iceland

(2013) Einar S. Björnsson et al.   GASTROENTEROLOGY

Associations Between HLA-DRB1*0102, HLA-B*5801, and Hepatotoxicity During Initiation of Nevirapine-Containing Regimens in South Africa

(2013) Elizabeth Phillips et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

HLA Haplotype Determines Hapten or p-i T Cell Reactivity to Flucloxacillin

(2013) N. Wuillemin et al.   JOURNAL OF IMMUNOLOGY

Hepatotoxicity from anabolic androgenic steroids marketed as dietary supplements: contribution fromATP8B1/ABCB11mutations?

(2013) Yasser El Sherrif et al.   LIVER INTERNATIONAL

HLA Alleles Influence the Clinical Signature of Amoxicillin-Clavulanate Hepatotoxicity

(2013) Camilla Stephens et al.   PLoS One

Studies on abacavir-induced hypersensitivity reaction: a successful example of translation of pharmacogenetics to personalized medicine

(2013) YongLi Guo et al.   Science China-Life Sciences

Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria

(2013) Derick Han et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Abacavir induces loading of novel self-peptides into HLA-B*57

(2012) Michael A. Norcross et al.   AIDS

Human leukocyte antigens (HLA) associated drug hypersensitivity: consequences of drug binding to HLA

(2012) J. Yun et al.   ALLERGY

Bioactivation of Nevirapine to a Reactive Quinone Methide: Implications for Liver Injury

(2012) Amy M. Sharma et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility

(2012) A Alfirevic et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Sterile Inflammation in the Liver

(2012) Paul Kubes et al.   GASTROENTEROLOGY

Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury

(2012) Manal M. Monshi et al.   HEPATOLOGY

Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome

(2012) Chun-Yu Wei et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

HLA and pharmacogenetics of drug hypersensitivity

(2012) Rebecca Pavlos et al.   PHARMACOGENOMICS

Genetic basis of susceptibility to drug-induced liver injury: what have we learned and where do we go from here?

(2012) Thomas J Urban et al.   PHARMACOGENOMICS

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire

(2012) D. A. Ostrov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs

(2012) Lee Faulkner et al.   TOXICOLOGICAL SCIENCES

The danger theory: 20 years later

(2012) Thomas Pradeu et al.   Frontiers in Immunology

Toxicogenomics of nevirapine-associated cutaneous and hepatic adverse events among populations of African, Asian, and European descent

(2011) Jing Yuan et al.   AIDS

Drug Hypersensitivity and Human Leukocyte Antigens of the Major Histocompatibility Complex

(2011) Mandvi Bharadwaj et al.   Annual Review of Pharmacology and Toxicology

Dabigatran Etexilate

(2011) Graeme J. Hankey et al.   CIRCULATION

Case Definition and Phenotype Standardization in Drug-Induced Liver Injury

(2011) G P Aithal et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles

(2011) M. Isabel Lucena et al.   GASTROENTEROLOGY

HLA-DQA1*02:01 Is a Major Risk Factor for Lapatinib-Induced Hepatotoxicity in Women With Advanced Breast Cancer

(2011) Colin F. Spraggs et al.   JOURNAL OF CLINICAL ONCOLOGY

Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis

(2011) P. Whitaker et al.   JOURNAL OF IMMUNOLOGY

Hepatotoxicity related to antirheumatic drugs

(2011) Guruprasad P. Aithal   Nature Reviews Rheumatology

Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity

(2010) B.K. Park et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Risk Factors for Idiosyncratic Drug-Induced Liver Injury

(2010) Naga Chalasani et al.   GASTROENTEROLOGY

Drug-induced liver injury: Is it time for genetics to change our clinical practice?

(2010) Pietro Invernizzi   JOURNAL OF HEPATOLOGY

Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury

(2010) Peter T. Donaldson et al.   JOURNAL OF HEPATOLOGY

Preempting and preventing drug-induced liver injury

(2010) Guruprasad P Aithal et al.   NATURE GENETICS

A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury

(2010) Jonathan B Singer et al.   NATURE GENETICS

Pharmacogenetics of drug hypersensitivity

(2010) Elizabeth J Phillips et al.   PHARMACOGENOMICS

Mechanisms of Immune-Mediated Liver Injury

(2010) David H. Adams et al.   TOXICOLOGICAL SCIENCES

Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation

(2009) Hayley E. Callan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSAin vitroandin vivo

(2009) Rosalind E. Jenkins et al.   Proteomics Clinical Applications

Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1

(2009) Rym Megherbi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Genome-wide association studies: past, present and future

(2008) M. I. McCarthy et al.   HUMAN MOLECULAR GENETICS

Human Leukocyte Antigen Class I-Restricted Activation of CD8+ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity

(2008) Diana Chessman et al.   IMMUNITY

HLA-B*5701 Screening for Hypersensitivity to Abacavir

(2008) Simon Mallal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pro-inflammatory response and adverse drug reactions: Mechanisms of action of ximelagatran on chemokine and cytokine activation in a monocyte in vitro model

(2008) Ylva Edling et al.   TOXICOLOGY IN VITRO

Idiosyncratic Drug Reactions: Past, Present, and Future

(2007) Jack Uetrecht   CHEMICAL RESEARCH IN TOXICOLOGY

Prediction of drug-induced liver injury in humans by using in vitro methods: The case of ximelagatran

(2007) Kerstin Kenne et al.   TOXICOLOGY IN VITRO