More than just summed neuronal activity: how multiple cell types shape the BOLD response

Caveolae in CNS arterioles mediate neurovascular coupling

(2020) Brian W. Chow et al.   NATURE

Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo

(2020) Amy R. Nelson et al.   Frontiers in Aging Neuroscience

The pericyte connectome: spatial precision of neurovascular coupling is driven by selective connectivity maps of pericytes and endothelial cells and is disrupted in diabetes

(2020) Tamas Kovacs-Oller et al.   Cell Discovery

The thermodynamics of thinking: connections between neural activity, energy metabolism and blood flow

(2020) Richard B. Buxton   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Rude mechanicals in brain haemodynamics: non-neural actors that influence blood flow

(2020) Aniruddha Das et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cross-species neuroscience: closing the explanatory gap

(2020) Helen C. Barron et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex

(2019) Pablo Garcia-Junco-Clemente et al.   Cell Reports

Vascular Compartmentalization of Functional Hyperemia from the Synapse to the Pia

(2019) Ravi L. Rungta et al.   NEURON

Endothelial NMDA receptors mediate activity-dependent brain hemodynamic responses in mice

(2019) Adam D. Hogan-Cann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Precise excitation-inhibition balance controls gain and timing in the hippocampus

(2019) Aanchal Bhatia et al.   eLife

Balanced synaptic currents underlie low‐frequency oscillations in the subiculum

(2019) Feliks Royzen et al.   HIPPOCAMPUS

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

(2019) Ross Nortley et al.   SCIENCE

More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction

(2019) Baoqiang Li et al.   eLife

Optogenetic assessment of VIP, PV, SOM and NOS inhibitory neuron activity and cerebral blood flow regulation in mouse somato-sensory cortex

(2019) Michael B Krawchuk et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocyte dysfunction and neurovascular impairment in neurological disorders: Correlation or causation?

(2019) Heather L. McConnell et al.   NEUROCHEMISTRY INTERNATIONAL

Key Aspects of Neurovascular Control Mediated by Specific Populations of Inhibitory Cortical Interneurons

(2019) L Lee et al.   CEREBRAL CORTEX

Modification of oxygen consumption and blood flow in mouse somatosensory cortex by cell-type-specific neuronal activity

(2019) Matilda K Dahlqvist et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neurovascular Coupling under Chronic Stress Is Modified by Altered GABAergic Interneuron Activity

(2019) Kayoung Han et al.   JOURNAL OF NEUROSCIENCE

The role of ongoing neuronal activity for baseline and stimulus-induced BOLD signals in the rat hippocampus

(2019) Frank Angenstein   NEUROIMAGE

Intercellular Conduction Optimizes Arterial Network Function and Conserves Blood Flow Homeostasis During Cerebrovascular Challenges

(2019) Anil Zechariah et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelium-dependent responses in the microcirculation observed in vivo

(2018) W. I. Rosenblum   Acta Physiologica

Optogenetic astrocyte activation evokes BOLD fMRI response with oxygen consumption without neuronal activity modulation

(2018) Norio Takata et al.   GLIA

The Role of Endothelial Ca2+ Signaling in Neurovascular Coupling: A View from the Lumen

(2018) Germano Guerra et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cortical Circuit Activity Evokes Rapid Astrocyte Calcium Signals on a Similar Timescale to Neurons

(2018) Jillian L. Stobart et al.   NEURON

Brain-state dependent astrocytic Ca2+signals are coupled to both positive and negative BOLD-fMRI signals

(2018) Maosen Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal control of astrocytic respiration through a variant of the Crabtree effect

(2018) Ignacio Fernández-Moncada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulation-induced increases in cerebral blood flow and local capillary vasoconstriction depend on conducted vascular responses

(2018) Changsi Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortical GABAergic Interneuron/Progenitor Transplantation as a Novel Therapy for Intractable Epilepsy

(2018) Qian Zhu et al.   Frontiers in Cellular Neuroscience

PV Interneurons: Critical Regulators of E/I Balance for Prefrontal Cortex-Dependent Behavior and Psychiatric Disorders

(2018) Brielle R. Ferguson et al.   Frontiers in Neural Circuits

Synchronized Astrocytic Ca 2+ Responses in Neurovascular Coupling during Somatosensory Stimulation and for the Resting State

(2018) Xiaochun Gu et al.   Cell Reports

Inhibitory Neuron Activity Contributions to Hemodynamic Responses and Metabolic Load Examined Using an Inhibitory Optogenetic Mouse Model

(2018) Alberto L Vazquez et al.   CEREBRAL CORTEX

PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

(2018) Osama F Harraz et al.   eLife

Two distinct profiles of fMRI and neurophysiological activity elicited by acetylcholine in visual cortex

(2018) Daniel Zaldivar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylcholine modulates gamma frequency oscillations in the hippocampus by activation of muscarinic M1 receptors

(2017) Ruth T. Betterton et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Fast Ca2+ responses in astrocyte end-feet and neurovascular coupling in mice

(2017) Barbara Lykke Lind et al.   GLIA

Organizational hierarchy and structural diversity of microvascular pericytes in adult mouse cortex

(2017) Roger I Grant et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Evaluating the gray and white matter energy budgets of human brain function

(2017) Yuguo Yu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Steady-State Free Ca 2+ in Astrocytes Is Decreased by Experience and Impacts Arteriole Tone

(2017) Eslam M.F. Mehina et al.   JOURNAL OF NEUROSCIENCE

Impact of Altered Cholinergic Tones on the Neurovascular Coupling Response to Whisker Stimulation

(2017) Clotilde Lecrux et al.   JOURNAL OF NEUROSCIENCE

Vascular Pericyte Impairment and Connexin43 Gap Junction Deficit Contribute to Vasomotor Decline in Diabetic Retinopathy

(2017) Elena Ivanova et al.   JOURNAL OF NEUROSCIENCE

Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow

(2017) Thomas A Longden et al.   NATURE NEUROSCIENCE

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

(2017) Kassandra Kisler et al.   NATURE NEUROSCIENCE

Vascular density and distribution in neocortex

(2017) Franca Schmid et al.   NEUROIMAGE

Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal Ripple Oscillations in Awake Mice In Vivo

(2017) Jian Gan et al.   NEURON

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Distinct age and differentiation-state dependent metabolic profiles of oligodendrocytes under optimal and stress conditions

(2017) Vijayaraghava T. S. Rao et al.   PLoS One

Glycogen distribution in the microwave-fixed mouse brain reveals heterogeneous astrocytic patterns

(2016) Yuki Oe et al.   GLIA

The capillary bed offers the largest hemodynamic resistance to the cortical blood supply

(2016) Ian Gopal Gould et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glial Cell Calcium Signaling Mediates Capillary Regulation of Blood Flow in the Retina

(2016) Kyle R. Biesecker et al.   JOURNAL OF NEUROSCIENCE

Semi-automated rapid quantification of brain vessel density utilizing fluorescent microscopy

(2016) Kaci A. Bohn et al.   JOURNAL OF NEUROSCIENCE METHODS

Neural correlates of single-vessel haemodynamic responses in vivo

(2016) Philip O’Herron et al.   NATURE

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

(2016) Anusha Mishra et al.   NATURE NEUROSCIENCE

Efficient codes and balanced networks

(2016) Sophie Denève et al.   NATURE NEUROSCIENCE

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

The interneuron energy hypothesis: Implications for brain disease

(2016) Oliver Kann   NEUROBIOLOGY OF DISEASE

Neuronal networks and mediators of cortical neurovascular coupling responses in normal and altered brain states

(2016) C. Lecrux et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

What is feasible with imaging human brain function and connectivity using functional magnetic resonance imaging

(2016) Kamil Ugurbil   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cell type specificity of neurovascular coupling in cerebral cortex

(2016) Hana Uhlirova et al.   eLife

Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer’s disease

(2015) Ian F. Kimbrough et al.   BRAIN

Optogenetic Stimulation of GABA Neurons can Decrease Local Neuronal Activity While Increasing Cortical Blood Flow

(2015) Eitan Anenberg et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Arteriole Dilation to Synaptic Activation that is Sub-Threshold to Astrocyte Endfoot Ca2+ Transients

(2015) Ádám Institoris et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Effects of Transit Time Heterogeneity on Brain Oxygenation during Rest and Functional Activation

(2015) Peter M Rasmussen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Effects of Capillary Transit Time Heterogeneity (CTH) on Brain Oxygenation

(2015) Hugo Angleys et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Early capillary flux homogenization in response to neural activation

(2015) Jonghwan Lee et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

What is a pericyte?

(2015) David Attwell et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocyte Ca2+ Signaling Drives Inversion of Neurovascular Coupling after Subarachnoid Hemorrhage

(2015) A. C. Pappas et al.   JOURNAL OF NEUROSCIENCE

Long-Latency Reductions in Gamma Power Predict Hemodynamic Changes That Underlie the Negative BOLD Signal

(2015) L. Boorman et al.   JOURNAL OF NEUROSCIENCE

Quantifying the Microvascular Origin of BOLD-fMRI from First Principles with Two-Photon Microscopy and an Oxygen-Sensitive Nanoprobe

(2015) L. Gagnon et al.   JOURNAL OF NEUROSCIENCE

Astrocyte Contributions to Flow/Pressure-Evoked Parenchymal Arteriole Vasoconstriction

(2015) K. J. Kim et al.   JOURNAL OF NEUROSCIENCE

Integration and Modulation of Intercellular Signaling Underlying Blood Flow Control

(2015) Steven S. Segal   JOURNAL OF VASCULAR RESEARCH

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

(2015) Robert A. Hill et al.   NEURON

Dopamine-Induced Dissociation of BOLD and Neural Activity in Macaque Visual Cortex

(2014) Daniel Zaldivar et al.   CURRENT BIOLOGY

Astrocytic Gq-GPCR-Linked IP3R-Dependent Ca2+ Signaling Does Not Mediate Neurovascular Coupling in Mouse Visual Cortex In Vivo

(2014) D. E. Bonder et al.   JOURNAL OF NEUROSCIENCE

Excitation and Inhibition Compete to Control Spiking during Hippocampal Ripples: Intracellular Study in Behaving Mice

(2014) Daniel F. English et al.   JOURNAL OF NEUROSCIENCE

Regulation of Blood Flow in the Retinal Trilaminar Vascular Network

(2014) T. E. Kornfield et al.   JOURNAL OF NEUROSCIENCE

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Calcium dynamics in astrocyte processes during neurovascular coupling

(2014) Yo Otsu et al.   NATURE NEUROSCIENCE

A supercritical density of Na+ channels ensures fast signaling in GABAergic interneuron axons

(2014) Hua Hu et al.   NATURE NEUROSCIENCE

A Critical Role for the Vascular Endothelium in Functional Neurovascular Coupling in the Brain

(2014) Brenda R. Chen et al.   Journal of the American Heart Association

In vivo Stimulus-Induced Vasodilation Occurs without IP3 Receptor Activation and May Precede Astrocytic Calcium Increase

(2013) K. Nizar et al.   JOURNAL OF NEUROSCIENCE

Imaging local neuronal activity by monitoring PO2 transients in capillaries

(2013) Alexandre Parpaleix et al.   NATURE MEDICINE

The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow

(2013) Pablo Blinder et al.   NATURE NEUROSCIENCE

Astrocyte-induced cortical vasodilation is mediated by D-serine and endothelial nitric oxide synthase

(2013) J. L. L. Stobart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid stimulus-evoked astrocyte Ca2+ elevations and hemodynamic responses in mouse somatosensory cortex in vivo

(2013) B. L. Lind et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxygen Consumption Rates during Three Different Neuronal Activity States in the Hippocampal CA3 Network

(2012) Christine Huchzermeyer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Updated Energy Budgets for Neural Computation in the Neocortex and Cerebellum

(2012) Clare Howarth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing

(2012) C. N. Hall et al.   JOURNAL OF NEUROSCIENCE

The Energetics of CNS White Matter

(2012) J. J. Harris et al.   JOURNAL OF NEUROSCIENCE

Simultaneous BOLD fMRI and fiber-optic calcium recording in rat neocortex

(2012) Kristina Schulz et al.   NATURE METHODS

Interneuron dysfunction in psychiatric disorders

(2012) Oscar Marín   NATURE REVIEWS NEUROSCIENCE

Spin-echo fMRI: The poor relation?

(2012) David G. Norris   NEUROIMAGE

The story of the initial dip in fMRI

(2012) Xiaoping Hu et al.   NEUROIMAGE

Activation of cortical 5-HT3 receptor-expressing interneurons induces NO mediated vasodilatations and NPY mediated vasoconstrictions

(2012) Quentin Perrenoud et al.   Frontiers in Neural Circuits

Neuronal nitric oxide synthase expressing neurons: a journey from birth to neuronal circuits

(2012) Ludovic Tricoire et al.   Frontiers in Neural Circuits

Normal Organ Weights in Men

(2011) D. Kimberley Molina et al.   AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY

Pyramidal Neurons Are "Neurogenic Hubs" in the Neurovascular Coupling Response to Whisker Stimulation

(2011) C. Lecrux et al.   JOURNAL OF NEUROSCIENCE

Activity-dependent Increases in Local Oxygen Consumption Correlate with Postsynaptic Currents in the Mouse Cerebellum In Vivo

(2011) C. Mathiesen et al.   JOURNAL OF NEUROSCIENCE

What Does Local Functional Hyperemia Tell about Local Neuronal Activation?

(2011) N. Jukovskaya et al.   JOURNAL OF NEUROSCIENCE

The electrotonic architecture of the retinal microvasculature: modulation by angiotensin II

(2011) Ting Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Local Ca2+ detection and modulation of synaptic release by astrocytes

(2011) Maria Amalia Di Castro et al.   NATURE NEUROSCIENCE

A general analysis of calibrated BOLD methodology for measuring CMRO2 responses: Comparison of a new approach with existing methods

(2011) Nicholas P. Blockley et al.   NEUROIMAGE

Role of Astrocytes in Neurovascular Coupling

(2011) Gabor C. Petzold et al.   NEURON

Neurovascular Coupling in Rat Brain Operates Independent of Hemoglobin Deoxygenation

(2010) Ute Lindauer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Largest Group of Superficial Neocortical GABAergic Interneurons Expresses Ionotropic Serotonin Receptors

(2010) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Negative Blood Oxygen Level Dependence in the Rat:A Model for Investigating the Role of Suppression in Neurovascular Coupling

(2010) L. Boorman et al.   JOURNAL OF NEUROSCIENCE

Soluble amyloid-β, effect on cerebral arteriolar regulation and vascular cells

(2010) Hans H Dietrich et al.   Molecular Neurodegeneration

Global and local fMRI signals driven by neurons defined optogenetically by type and wiring

(2010) Jin Hyung Lee et al.   NATURE

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

Modes and Models of Forebrain Cholinergic Neuromodulation of Cognition

(2010) Michael E Hasselmo et al.   NEUROPSYCHOPHARMACOLOGY

Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal

(2010) P. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Odor-Evoked Oxygen Consumption by Action Potential and Synaptic Transmission in the Olfactory Bulb

(2009) J. Lecoq et al.   JOURNAL OF NEUROSCIENCE

An integrative model for neuronal activity-induced signal changes for gradient and spin echo functional imaging

(2009) Kâmil Uludağ et al.   NEUROIMAGE

Sodium Entry during Action Potentials of Mammalian Neurons: Incomplete Inactivation and Reduced Metabolic Efficiency in Fast-Spiking Neurons

(2009) Brett C. Carter et al.   NEURON

Energy-Efficient Action Potentials in Hippocampal Mossy Fibers

(2009) H. Alle et al.   SCIENCE

Four grams of glucose

(2008) David H. Wasserman   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cerebrovascular Dysfunction in Amyloid Precursor Protein Transgenic Mice: Contribution of Soluble and Insoluble Amyloid-  Peptide, Partial Restoration via  -Secretase Inhibition

(2008) B. H. Han et al.   JOURNAL OF NEUROSCIENCE

What we can do and what we cannot do with fMRI

(2008) Nikos K. Logothetis   NATURE

Behavioral correlates of negative BOLD signal changes in the primary somatosensory cortex

(2008) Andreas Kastrup et al.   NEUROIMAGE

The effect of a serotonin-induced dissociation between spiking and perisynaptic activity on BOLD functional MRI

(2008) A. Rauch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuned Responses of Astrocytes and Their Influence on Hemodynamic Signals in the Visual Cortex

(2008) J. Schummers et al.   SCIENCE

Fine Detail of Neurovascular Coupling Revealed by Spatiotemporal Analysis of the Hemodynamic Response to Single Whisker Stimulation in Rat Barrel Cortex

(2007) J. Berwick et al.   JOURNAL OF NEUROPHYSIOLOGY

Trial-by-trial relationship between neural activity, oxygen consumption, and blood flow responses

(2007) Kazuto Masamoto et al.   NEUROIMAGE