Review
Neurosciences
Garikoitz Azkona, Rosario Sanchez-Pernaute
Summary: Animal models are crucial in neuroscience research, but there are recurring issues in data collection and interpretation, a lack of biomarkers, and an over-reliance on mice, leading to low translation efficiency. Non-human primates, with their higher brain complexity and similarity to humans, can provide more relevant translational information. Therefore, resources for training, education, husbandry, and data sharing should be prioritized to improve translational efficiency.
PROGRESS IN NEUROBIOLOGY
(2022)
Editorial Material
Ecology
Morelia Camacho-Cervantes, Bob B. M. Wong
Summary: This article discusses how pollution alters species interactions by impacting wildlife behavior, influencing invasion dynamics. Addressing knowledge gaps is crucial for the management of invasive species and the conservation of native ecosystems in an increasingly toxic world.
TRENDS IN ECOLOGY & EVOLUTION
(2023)
Article
Nanoscience & Nanotechnology
Zhibao Huang, Zenan Zhou, Jiasheng Zeng, Sen Lin, Hui Wu
Summary: This Perspective provides a brief review and summary of flexible electrode technologies for non-invasive brain-computer interfaces (BCIs), focusing on dry electrodes and semi-dry electrodes. The challenges faced by different types of electrodes are discussed, along with their strengths and weaknesses in terms of manufacturing scalability, applicability, comfort, contact impedance, long-term stability, and biocompatibility. Advanced configurations and potential applications for non-invasive BCIs based on flexible electrodes are described, and future development prospects are considered.
Article
Biology
Nabil Benzina, Karim N'Diaye, Antoine Pelissolo, Luc Mallet, Eric Burguiere
Summary: The study examines behavioral flexibility in human and mouse models of obsessive compulsive disorder (OCD) using a reversal learning task. The findings show that only subsets of human patients or OCD-like mice exhibit deficits in behavioral flexibility, underscoring the diverse presentation of cognitive deficits in compulsive disorders.
COMMUNICATIONS BIOLOGY
(2021)
Review
Ecology
Peter S. Stewart, Russell A. Hill, Philip A. Stephens, Mark J. Whittingham, Wayne Dawson
Summary: This study investigates how invasive plants impact the behavior of native animals, introducing a mechanistic framework to understand these impacts. While some behavioral impacts of invasive plants are well-covered in the literature, others are supported by only a handful of studies, indicating the need for further exploration. The study concludes by identifying priority topics for future research, emphasizing the benefit of an interdisciplinary approach uniting invasion ecology with the study of animal behavior and cognition.
Review
Clinical Neurology
Henriette Edemann-Callesen, Christine Winter, Ravit Hadar
Summary: Schizophrenia is considered a neurodevelopmental disorder, and early interventions may help prevent later manifestation of symptoms. Research indicates that early non-invasive neuromodulation to the prefrontal cortex of adolescent animals can effectively prevent later psychosis-relevant abnormalities in adulthood, demonstrating promising potential for preventive treatment.
Review
Multidisciplinary Sciences
Fay E. Clark, Alison L. Greggor, Stephen H. Montgomery, Joshua M. Plotnik
Summary: Endangered species face small and unsustainable populations due to geographical and genetic restrictions. Ex-situ conservation programs need to breed genetically diverse populations with the necessary skills to survive and breed in the wild. However, research suggests that certain cognitive-behavioral skills and flexibility are necessary to cope with human-induced rapid environmental change (HIREC).
ROYAL SOCIETY OPEN SCIENCE
(2023)
Review
Behavioral Sciences
Julie Royo, Stephanie J. Forkel, Pierre Pouget, Michel Thiebaut de Schotten
Summary: Animal models in clinical neuroscience research offer valuable insights into human brain function and pathologies. While rodent models are commonly used due to their similarities with humans, some disorders require primate models like macaques. However, limitations such as high costs and small sample sizes hinder primate model research, making squirrel monkeys a potential bridge to complement and improve translational discoveries in brain pathology research.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Veterinary Sciences
Charlene Leconstant, Elisabeth Spitz
Summary: The Integrative Model of Human-Animal Interactions (IMHAI) provides a framework for studying interspecies interactions and focuses on modeling the primary emotional processes involved. This model integrates inputs from neuroscience, psychology, and ethology to promote collaboration between professionals and researchers. Based on evidence from affective neuroscience, the model explores primary emotions shared between humans and animals and the role of safety perception in determining physiological states. The IMHAI aims to understand emotional affects during interspecies social interactions, including emotional transfer, embodied communication, and interactive emotional regulation, to generate new hypotheses and predictions on affective behavior and interspecies communication.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Behavioral Sciences
Martina Manns, Yasmin El Basbasse, Nadja Freund, Sebastian Ocklenburg
Summary: Mice and rats show significant hemispheric asymmetries at the individual level, with a preference for either the left or right paw. However, unlike humans, population level asymmetries were not observed. These results highlight the importance of considering individual hemispheric differences in both basic and clinical neuroscience.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Ecology
Rachel L. L. Gunn, Cassandra E. E. Benkwitt, Nicholas A. J. Graham, Ian R. R. Hartley, Adam C. C. Algar, Sally A. A. Keith
Summary: Human-induced environmental changes, such as the introduction of invasive species, can disrupt nutrient flows across ecosystems and have negative consequences for ecosystem function. In this study, we found that an invasive species (black rats) disrupts a nutrient pathway provided by seabirds, leading to changes in territorial behavior of coral reef fish. Rat eradication as a conservation strategy has the potential to restore species interactions and influence populations and communities at higher ecological levels.
NATURE ECOLOGY & EVOLUTION
(2023)
Article
Optics
Li Lin, Xin Tong, Susana Cavallero, Yide Zhang, Shuai Na, Rui Cao, Tzung K. Hsiai, Lihong V. Wang
Summary: Complementary to mainstream cardiac imaging modalities, photoacoustic computed tomography (PACT) provides functional optical contrast with high speed and resolution. The non-invasive imaging achieved using the 3D-PACT platform enables visualization of whole cardiac anatomy and intracardiac hemodynamics. This technology can reveal distinct cardiac changes among different animal models and holds promise for clinical translation to human neonates' cardiac imaging.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Patrick Vagenknecht, Artur Luzgin, Maiko Ono, Bin Ji, Makoto Higuchi, Daniela Noain, Cinzia A. Maschio, Jens Sobek, Zhenyue Chen, Uwe Konietzko, Juan A. Gerez, Roland Riek, Daniel Razansky, Jan Klohs, Roger M. Nitsch, Xose Luis Dean-Ben, Ruiqing Ni
Summary: This study demonstrated high-resolution imaging of tau protein in the whole brain of mice using non-invasive imaging technique. The results showed that the tau-targeted probe PBB5 specifically bound to tau protein and exhibited similar binding ability in diseased brain tissue.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Behavioral Sciences
J. A. Daniels, P. S. Kemp
Summary: Intraspecific variation in personality traits can influence the behavior of aquatic invasive species at anthropogenic barriers, as demonstrated by the study on American signal crayfish at Crump weir. Boldness and activity levels were found to be positively correlated with motivation to pass the weir, but sociability did not show repeatability and was not classified as a personality trait.
Article
Biochemistry & Molecular Biology
Roxan F. C. P. A. Helderman, Mauricio Tobon Restrepo, Hans M. Rodermond, Gregor G. W. van Bochove, Daan R. Loke, Nicolaas A. P. Franken, H. Petra Kok, Pieter J. Tanis, Johannes Crezee, Arlene L. Oei
Summary: Ultrasound is a reliable non-invasive method to detect and quantify the growth of intraperitoneal tumor nodules in a rat model.
Article
Neurosciences
Lea Roumazeilles, Frederik J. Lange, R. Austin Benn, Jesper L. R. Andersson, Mads F. Bertelsen, Paul R. Manger, Edmund Flach, Alexandre A. Khrapitchev, Katherine L. Bryant, Jerome Sallet, Rogier B. Mars
Summary: Comparative neuroimaging of ring-tailed lemurs, black-capped squirrel monkeys, and rhesus macaques revealed differences in frontal projections and white matter architecture. The results suggest that squirrel monkeys and rhesus macaques have expanded frontal projections compared to ring-tailed lemurs, while ring-tailed lemurs have reduced connectivity in the parietal region. Furthermore, squirrel monkeys have a specific occipito-parietal anatomy.
Article
Neurosciences
Dirk Jan Ardesch, Lianne H. Scholtens, Siemon C. de Lange, Lea Roumazeilles, Alexandre A. Khrapitchev, Todd M. Preuss, James K. Rilling, Rogier B. Mars, Martijn P. van den Heuvel
Summary: The study found that as brain size increases, there are restrictions on macroscopic connectivity, leading to lower overall connectedness, sparser long-range connectivity, and longer communication paths. Additionally, there were asymmetries in connectivity patterns between homologous areas across the left and right hemispheres in larger brains.
Article
Biochemistry & Molecular Biology
Francesca Mandino, Roel M. Vrooman, Heidi E. Foo, Ling Yun Yeow, Thomas A. W. Bolton, Piergiorgio Salvan, Chai Lean Teoh, Chun Yao Lee, Antoine Beauchamp, Sarah Luo, Renzhe Bi, Jiayi Zhang, Guan Hui Tricia Lim, Nathaniel Low, Jerome Sallet, John Gigg, Jason P. Lerch, Rogier B. Mars, Malini Olivo, Yu Fu, Joanes Grandjean
Summary: The triple-network model is a framework for understanding psychiatric and neurological disorders, showing interactions between three networks. Researchers found conserved spatio-temporal properties across human, macaque, and mouse, and validated model predictions in a mouse model for depression.
MOLECULAR PSYCHIATRY
(2022)
Article
Biology
Benjamin C. Tendler, Taylor Hanayik, Olaf Ansorge, Sarah Bangerter-Christensen, Gregory S. Berns, Mads F. Bertelsen, Katherine L. Bryant, Sean Foxley, Martijn P. van den Heuvel, Amy F. D. Howard, Istvan N. Huszar, Alexandre A. Khrapitchev, Anna Leonte, Paul R. Manger, Ricarda A. L. Menke, Jeroen Mollink, Duncan Mortimer, Menuka Pallebage-Gamarallage, Lea Roumazeilles, Jerome Sallet, Lianne H. Scholtens, Connor Scott, Adele Smart, Martin R. Turner, Chaoyue Wang, Saad Jbabdi, Rogier B. Mars, Karla L. Miller
Summary: The Digital Brain Bank is a data release platform that provides open access to curated, multimodal post-mortem neuroimaging datasets. It includes datasets for detailed neuroanatomical investigations, comparative neuroanatomy, and neuropathology investigations. The platform's first data release includes high-resolution whole-brain diffusion MRI datasets for structural connectivity investigations, making it one of the largest studies in neurodegeneration.
Article
Clinical Neurology
Zeena Britt Sanders, Melanie K. Fleming, Tom Smejka, Marilien C. Marzolla, Catharina Zich, Sebastian W. Rieger, Michael Luhrs, Rainer Goebel, Cassandra Sampaio-Baptista, Heidi Johansen-Berg
Summary: Chronic stroke survivors can use real-time fMRI neurofeedback to self-regulate motor cortex activity, leading to improvements in gross motor performance of the affected limb and structural brain changes.
Article
Neurosciences
Nikki Janssen, Roy P. C. Kessels, Rogier B. Mars, Alberto Llera, Christian F. Beckmann, Ardi Roelofs
Summary: Recent studies have shown that the left arcuate fasciculus (AF) consists of at least two segments that connect the temporal and frontal cortex. These segments play different functional roles in speech production, with one segment responsible for sublexical phonological mapping and the other segment responsible for lexical-semantic mapping.
Article
Multidisciplinary Sciences
Joanna Sierpowska, Katherine L. Bryant, Nikki Janssen, Guilherme Blazquez Freches, Manon Romkens, Margot Mangnus, Rogier B. Mars, Vitoria Piai
Summary: This study reveals the anatomical differences in language connectivity between humans and chimpanzees. Compared to chimpanzees, humans have expanded connectivity in the posterior temporal lobe, not only to the ventral frontal cortex but also to the parietal cortex. Conversely, chimpanzees have stronger connectivity between the posterior temporal regions and the ventral white matter. Additionally, humans have unique combinations of connections through different bundles in the anterior temporal lobe, which may underlie the anatomical basis for full-fledged language capacity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Psychology, Experimental
Francesco Poli, Marlene Meyer, Rogier B. Mars, Sabine Hunnius
Summary: This study reveals that curiosity-driven exploration is guided by learning progress and perceptual novelty, and participants tend to avoid extreme forms of uncertainty when exploring unknown environments.
Article
Anatomy & Morphology
Maryann P. Noonan, Maiya R. Geddes, Rogier B. Mars, Lesley K. Fellows
Summary: Lesion research not only focuses on the directly injured brain region, but also considers distant effects. In this study, multiple MRI imaging modalities were used to investigate network organization in patients with chronic focal damage and healthy controls. The results suggest widespread grey matter loss in distal regions, but relatively preserved white matter and resting state networks. Lesions to the prefrontal region had a similar impact on both structural and functional networks.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Stephen B. McHugh, Vitor Lopes-dos-Santos, Giuseppe P. Gava, Katja Hartwich, Shu K. E. Tam, David M. Bannerman, David Dupret
Summary: The study reveals the crucial role of adult-born granule cells (abDGCs) in controlling the information processing in the hippocampus by promoting sparser population firing and enhancing responses to novel stimuli.
NATURE NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Shaun Warrington, Elinor Thompson, Matteo Bastiani, Jessica Dubois, Luke Baxter, Rebeccah Slater, Saad Jbabdi, Rogier B. Mars, Stamatios N. Sotiropoulos
Summary: This study proposes a novel framework that integrates structural connectivity maps from humans and nonhuman primates onto a common space, allowing the study of divergences and similarities in connectivity over evolutionary and developmental scales to reveal brain maturation trajectories.
Article
Multidisciplinary Sciences
Colin Reveley, Frank Q. Ye, Rogier B. Mars, Denis Matrov, Yogita Chudasama, David A. Leopold
Summary: In this study, the authors combined ex vivo high-resolution diffusion magnetic resonance imaging (dMRI) of marmoset brain with histological sections of the same brain to investigate the contributions of myelinated axons and other tissue features to dMRI in the gray matter. They found that dMRI fractional anisotropy (dMRI-FA) did not match the spatial distribution of myelin in the gray matter, but was more closely related to the anisotropy of stained tissue features, particularly those revealed by Nissl staining.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Antoine Beauchamp, Yohan Yee, Ben C. Darwin, Armin Raznahan, Rogier B. Mars, Jason P. Lerch
Summary: Researchers use a common reference space approach to evaluate the similarity between mouse and human brain, finding that mouse-human homologous genes can capture general patterns of neuroanatomical organization. By using a supervised machine learning approach, the resolution of cross-species correspondences can be improved.
Article
Neurosciences
Joanes Grandjean, Gabriel Desrosiers-Gregoire, Cynthia Anckaerts, Diego Angeles-Valdez, Fadi Ayad, David A. Barriere, Ines Blockx, Aleksandra Bortel, Margaret Broadwater, Beatriz M. Cardoso, Marina Celestine, Jorge E. Chavez-Negrete, Sangcheon Choi, Emma Christiaen, Perrin Clavijo, Luis Colon-Perez, Samuel Cramer, Tolomeo Daniele, Elaine Dempsey, Yujian Diao, Arno Doelemeyer, David Dopfel, Lenka Dvorakova, Claudia Falfan-Melgoza, Francisca F. Fernandes, Caitlin F. Fowler, Antonio Fuentes-Ibanez, Clement Garin, Eveline Gelderman, Carla E. M. Golden, Chao C. G. Guo, Marloes J. A. G. Henckens, Lauren A. Hennessy, Peter Herman, Nita Hofwijks, Corey Horien, Tudor M. Ionescu, Jolyon Jones, Johannes Kaesser, Eugene Kim, Henriette Lambers, Alberto Lazari, Sung-Ho Lee, Amanda Lillywhite, Yikang Liu, Yanyan Y. Liu, Alejandra Lopez-Castro, Xavier Lopez-Gil, Zilu Ma, Eilidh MacNicol, Dan Madularu, Francesca Mandino, Sabina Marciano, Matthew J. McAuslan, Patrick McCunn, Alison McIntosh, Xianzong Meng, Lisa Meyer-Baese, Stephan Missault, Federico Moro, Daphne M. P. Naessens, Laura J. Nava-Gomez, Hiroi Nonaka, Juan J. Ortiz, Jaakko Paasonen, Lore M. Peeters, Mickael Pereira, Pablo D. Perez, Marjory Pompilus, Malcolm Prior, Rustam Rakhmatullin, Henning M. Reimann, Jonathan Reinwald, Rodrigo Triana Del Rio, Alejandro Rivera-Olvera, Daniel Ruiz-Perez, Gabriele Russo, Tobias J. Rutten, Rie Ryoke, Markus Sack, Piergiorgio Salvan, Basavaraju G. Sanganahalli, Aileen Schroeter, Bhedita J. Seewoo, Erwan Selingue, Aline Seuwen, Bowen Shi, Nikoloz Sirmpilatze, Joanna A. Smith, Corrie Smith, Filip Sobczak, Petteri J. Stenroos, Milou Straathof, Sandra Strobelt, Akira Sumiyoshi, Kengo Takahashi, Maria E. Torres-Garcia, Raul Tudela, Monica van den Berg, Kajo van der Marel, Aran T. B. van Hout, Roberta Vertullo, Benjamin Vidal, Roel M. Vrooman, Victora X. Wang, Isabel Wank, David J. G. Watson, Ting Yin, Yongzhi Zhang, Stefan Zurbruegg, Sophie Achard, Sarael Alcauter, Dorothee P. Auer, Emmanuel L. Barbier, Juergen Baudewig, Christian F. Beckmann, Nicolau Beckmann, Guillaume J. P. C. Becq, Erwin L. A. Blezer, Radu Bolbos, Susann Boretius, Sandrine Bouvard, Eike Budinger, Joseph D. Buxbaum, Diana Cash, Victoria Chapman, Kai-Hsiang Chuang, Luisa Ciobanu, Bram F. Coolen, Jeffrey W. Dalley, Marc Dhenain, Rick M. Dijkhuizen, Oscar Esteban, Cornelius Faber, Marcelo Febo, Kirk W. Feindel, Gianluigi Forloni, Jeremie Fouquet, Eduardo A. Garza-Villarreal, Natalia Gass, Jeffrey C. Glennon, Alessandro Gozzi, Olli Grohn, Andrew Harkin, Arend Heerschap, Xavier Helluy, Kristina Herfert, Arnd Heuser, Judith R. Homberg, Danielle J. Houwing, Fahmeed Hyder, Giovanna Diletta Ielacqua, Ileana O. Jelescu, Heidi Johansen-Berg, Gen Kaneko, Ryuta Kawashima, Shella D. Keilholz, Georgios A. Keliris, Clare Kelly, Christian Kerskens, Jibran Y. Khokhar, Peter C. Kind, Jean-Baptiste Langlois, Jason P. Lerch, Monica A. Lopez-Hidalgo, Denise Manahan-Vaughan, Fabien Marchand, Rogier B. Mars, Gerardo Marsella, Edoardo Micotti, Emma Munoz-Moreno, Jamie Near, Thoralf Niendorf, Willem M. Otte, Patricia Pais-Roldan, Wen-Ju Pan, Roberto A. Prado-Alcala, Gina L. Quirarte, Jennifer Rodger, Tim Rosenow, Cassandra Sampaio-Baptista, Alexander Sartorius, Stephen J. Sawiak, Tom W. J. Scheenen, Noam Shemesh, Yen-Yu Ian Shih, Amir Shmuel, Guadalupe Soria, Ron Stoop, Garth J. Thompson, Sally M. Till, Nick Todd, Annemie van der Linden, Annette van der Toorn, Geralda A. F. van Tilborg, Christian Vanhove, Andor Veltien, Marleen Verhoye, Lydia Wachsmuth, Wolfgang Weber-Fahr, Patricia Wenk, Xin Yu, Valerio Zerbi, Nanyin Zhang, Baogui B. Zhang, Luc Zimmer, Gabriel A. Devenyi, M. Mallar Chakravarty, Andreas Hess
Summary: Task-free functional connectivity in animal models is an important tool for studying connectivity phenomena. However, the lack of standardized protocols and analysis methods hampers result comparison and integration. In this study, the authors developed a standardized protocol, called StandardRat, for rat functional magnetic resonance imaging (fMRI) acquisition and analysis, which enhances the detection of functional connectivity patterns and promotes cooperation in neuroscience research.
NATURE NEUROSCIENCE
(2023)
Review
Neurosciences
Antonio Fernandez-Ruiz, Anton Sirota, Vitor Lopes-dos-Santos, David Dupret
Summary: Gamma oscillations (-30-150 Hz) are widespread correlates of neural circuit functions. These network activity patterns have been described across multiple animal species, brain structures, and behaviors, and are usually identified based on their spectral peak frequency. However, whether gamma oscillations implement specific brain functions or represent a general dynamic mode of neural circuit operation remains unclear. This perspective reviews recent advances in the study of gamma oscillations and proposes shifting the attention from a frequency-based to a circuit-level definition.