Crystal structure of a tick-borne flavivirus RNA-dependent RNA polymerase suggests a host adaptation hotspot in RNA viruses

Structural basis for RNA replication by the SARS-CoV-2 polymerase

(2020) Quan Wang et al.   CELL

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

(2020) Yan Gao et al.   SCIENCE

Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures

(2020) Meihua Wang et al.   Nature Communications

A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase

(2020) Jiqin Wu et al.   PLoS Pathogens

Detection of Jingmen tick virus in human patient specimens: Emergence of a new tick-borne human disease?

(2019) Satoshi Taniguchi   EBioMedicine

Emergence of human infection with Jingmen tick virus in China: A retrospective study

(2019) Na Jia et al.   EBioMedicine

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

(2019) Robert N. Kirchdoerfer et al.   Nature Communications

A Structure-Function Diversity Survey of the RNA-Dependent RNA Polymerases From the Positive-Strand RNA Viruses

(2019) Hengxia Jia et al.   Frontiers in Microbiology

Insights into the Host Range, Genetic Diversity, and Geographical Distribution of Jingmenviruses

(2019) Sarah Temmam et al.   mSphere

Zika Virus Attenuation by Codon Pair Deoptimization Induces Sterilizing Immunity in Mouse Models

(2018) Penghui Li et al.   JOURNAL OF VIROLOGY

Crystal Structure of Classical Swine Fever Virus NS5B Reveals a Novel N-Terminal Domain

(2018) Weiwei Li et al.   JOURNAL OF VIROLOGY

Origins and Evolution of the Global RNA Virome

(2018) Yuri I. Wolf et al.   mBio

A Review of Flaviviruses that Have No Known Arthropod Vector

(2017) Bradley Blitvich et al.   Viruses-Basel

Historical Perspectives on Flavivirus Research

(2017) Michael Holbrook   Viruses-Basel

Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter

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A Structural Overview of RNA-Dependent RNA Polymerases from the Flaviviridae Family

(2015) Jiqin Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Divergent Viruses Discovered in Arthropods and Vertebrates Revise the Evolutionary History of the Flaviviridae and Related Viruses

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Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses

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Structural basis for RNA replication by the hepatitis C virus polymerase

(2015) T. C. Appleby et al.   SCIENCE

Insect-Specific Flaviviruses: A Systematic Review of Their Discovery, Host Range, Mode of Transmission, Superinfection Exclusion Potential and Genomic Organization

(2015) Bradley Blitvich et al.   Viruses-Basel

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

(2015) Yongqian Zhao et al.   PLoS Pathogens

Common and unique features of viral RNA-dependent polymerases

(2014) Aartjan J. W. te Velthuis   CELLULAR AND MOLECULAR LIFE SCIENCES

Dating the origin of the genus Flavivirus in the light of Beringian biogeography

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Perturbation in the Conserved Methyltransferase-Polymerase Interface of Flavivirus NS5 Differentially Affects Polymerase Initiation and Elongation

(2014) Jiqin Wu et al.   JOURNAL OF VIROLOGY

Structure of influenza A polymerase bound to the viral RNA promoter

(2014) Alexander Pflug et al.   NATURE

A tick-borne segmented RNA virus contains genome segments derived from unsegmented viral ancestors

(2014) X.-C. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication

(2014) Xiao-Dan Li et al.   PLoS Neglected Tropical Diseases

Recovery of a chemically synthesized Japanese encephalitis virus reveals two critical adaptive mutations in NS2B and NS4A

(2013) X.-D. Li et al.   JOURNAL OF GENERAL VIROLOGY

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface

(2013) Guoliang Lu et al.   PLoS Pathogens

Assembly, Purification, and Pre-steady-state Kinetic Analysis of Active RNA-dependent RNA Polymerase Elongation Complex

(2012) Zhinan Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular evolution of the insect-specific flaviviruses

(2011) S. Cook et al.   JOURNAL OF GENERAL VIROLOGY

Functional RNA Elements in the Dengue Virus Genome

(2011) Leopoldo G. Gebhard et al.   Viruses-Basel

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Tick-Borne Flaviviruses

(2010) P. Rocco LaSala et al.   CLINICS IN LABORATORY MEDICINE

Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase

(2010) P. Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into Mechanisms of Catalysis and Inhibition in Norwalk Virus Polymerase

(2008) Dmitry F. Zamyatkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-directed, Ligase-Independent Mutagenesis (SLIM) for highly efficient mutagenesis of plasmids greater than 8kb

(2008) Joyce Chiu et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Terminal structures of West Nile virus genomic RNA and their interactions with viral NS5 protein

(2008) Hongping Dong et al.   VIROLOGY