A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase

Supramolecular arrangement of the full-length Zika virus NS5

(2019) Diego S. Ferrero et al.   PLoS Pathogens

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

(2019) Robert N. Kirchdoerfer et al.   Nature Communications

Structure of the yellow fever NS5 protein reveals conserved drug targets shared among flaviviruses

(2019) Anna Dubankova et al.   ANTIVIRAL RESEARCH

NS5 from Dengue Virus Serotype 2 Can Adopt a Conformation Analogous to That of Its Zika Virus and Japanese Encephalitis Virus Homologues

(2019) Abbas El Sahili et al.   JOURNAL OF VIROLOGY

Tick-Borne Encephalitis Virus Nonstructural Protein NS5 Induces RANTES Expression Dependent on the RNA-Dependent RNA Polymerase Activity

(2018) Zifeng Zheng et al.   JOURNAL OF IMMUNOLOGY

A planarian nidovirus expands the limits of RNA genome size

(2018) Amir Saberi et al.   PLoS Pathogens

The uncoupling of catalysis and translocation in the viral RNA-dependent RNA polymerase

(2017) Bo Shu et al.   RNA Biology

A structural view of the RNA-dependent RNA polymerases from the Flavivirus genus

(2017) Guoliang Lu et al.   VIRUS RESEARCH

The structure of Zika virus NS5 reveals a conserved domain conformation

(2017) Boxiao Wang et al.   Nature Communications

Structure and function of the Zika virus full-length NS5 protein

(2017) Baoyu Zhao et al.   Nature Communications

Crystal structures of the methyltransferase and helicase from the ZIKA 1947 MR766 Uganda strain

(2017) Malgorzata Bukrejewska et al.   Acta Crystallographica Section D-Structural Biology

Crystal structure of full-lengthZika virusNS5 protein reveals a conformation similar toJapanese encephalitis virusNS5

(2017) Anup K. Upadhyay et al.   Acta Crystallographica Section F-Structural Biology Communications

Zika Virus: New Clinical Syndromes and Its Emergence in the Western Hemisphere

(2016) Helen M. Lazear et al.   JOURNAL OF VIROLOGY

Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation

(2016) Bo Shu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural polymerase fusion as an initiation regulator?

(2016) Guoliang Lu et al.   Oncotarget

Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface

(2016) Valerie J. Klema et al.   PLoS Pathogens

Identification of the critical linker residues conferring differences in the compactness of NS5 fromDengue virusserotype 4 and NS5 fromDengue virusserotypes 1–3

(2016) Malathy Sony Subramanian Manimekalai et al.   Acta Crystallographica Section D-Structural Biology

Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter

(2015) Piotr Gerlach et al.   CELL

Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy

(2015) Bo Liang et al.   CELL

A Structural Overview of RNA-Dependent RNA Polymerases from the Flaviviridae Family

(2015) Jiqin Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

(2015) Yongqian Zhao et al.   PLoS Pathogens

Structural insight and flexible features of NS5 proteins from all four serotypes of Dengue virus in solution

(2015) Wuan Geok Saw et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Perturbation in the Conserved Methyltransferase-Polymerase Interface of Flavivirus NS5 Differentially Affects Polymerase Initiation and Elongation

(2014) Jiqin Wu et al.   JOURNAL OF VIROLOGY

Structure of influenza A polymerase bound to the viral RNA promoter

(2014) Alexander Pflug et al.   NATURE

The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

(2014) Supanee Potisopon et al.   NUCLEIC ACIDS RESEARCH

The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication

(2014) Xiao-Dan Li et al.   PLoS Neglected Tropical Diseases

A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability andde NovoInitiation Activities

(2013) Siew Pheng Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recovery of a chemically synthesized Japanese encephalitis virus reveals two critical adaptive mutations in NS2B and NS4A

(2013) X.-D. Li et al.   JOURNAL OF GENERAL VIROLOGY

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface

(2013) Guoliang Lu et al.   PLoS Pathogens

Snapshots of a viral RNA polymerase switching gears from transcription initiation to elongation

(2013) Karsten Theis   VIROLOGICA SINICA

Dengue Virus Nonstructural Protein 5 Adopts Multiple Conformations in Solution

(2012) Cécile Bussetta et al.   BIOCHEMISTRY

Assembly, Purification, and Pre-steady-state Kinetic Analysis of Active RNA-dependent RNA Polymerase Elongation Complex

(2012) Zhinan Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Analysis of Two Cavities in Flavivirus NS5 Polymerase

(2011) Gang Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Poliovirus Polymerase Residue 5 Plays a Critical Role in Elongation Complex Stability

(2010) S. E. Hobdey et al.   JOURNAL OF VIROLOGY

CRM1-mediated Nuclear Export of Dengue Virus RNA Polymerase NS5 Modulates Interleukin-8 Induction and Virus Production

(2009) Stephen M. Rawlinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Flavivirus NS5 Methyltransferase Cap Binding

(2008) Brian J. Geiss et al.   JOURNAL OF MOLECULAR BIOLOGY