Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication

Two-amino acids change in the nsp4 of SARS coronavirus abolishes viral replication

(2017) Yusuke Sakai et al.   VIROLOGY

Bioinformatics and functional analyses of coronavirus nonstructural proteins involved in the formation of replicative organelles

(2016) Benjamin W. Neuman   ANTIVIRAL RESEARCH

Ultrastructural characterization of membranous torovirus replication factories

(2016) Ginés Ávila-Pérez et al.   CELLULAR MICROBIOLOGY

SARS and MERS: recent insights into emerging coronaviruses

(2016) Emmie de Wit et al.   NATURE REVIEWS MICROBIOLOGY

Biogenesis and architecture of arterivirus replication organelles

(2016) Barbara van der Hoeven et al.   VIRUS RESEARCH

Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly

(2016) Inés Romero-Brey et al.   Viruses-Basel

Antiviral Innate Immune Response Interferes with the Formation of Replication-Associated Membrane Structures Induced by a Positive-Strand RNA Virus

(2016) Diede Oudshoorn et al.   mBio

The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds

(2015) Yahira M. Báez-Santos et al.   ANTIVIRAL RESEARCH

NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication

(2015) Inés Romero-Brey et al.   mBio

Untangling Membrane Rearrangement in the Nidovirales

(2014) Megan Mary Angelini et al.   DNA AND CELL BIOLOGY

From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

(2014) Rolf Hilgenfeld   FEBS Journal

Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression

(2014) Ben A. Bailey-Elkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations across Murine Hepatitis Virus nsp4 Alter Virus Fitness and Membrane Modifications

(2014) Dia C. Beachboard et al.   JOURNAL OF VIROLOGY

Membrane rearrangements mediated by coronavirus nonstructural proteins 3 and 4

(2014) Marne C. Hagemeijer et al.   VIROLOGY

Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities

(2014) Anna M. Mielech et al.   VIRUS RESEARCH

Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome Virus

(2014) Anna Lundin et al.   PLoS Pathogens

Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease

(2013) X. Yang et al.   JOURNAL OF GENERAL VIROLOGY

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-  treatment

(2013) A. H. de Wilde et al.   JOURNAL OF GENERAL VIROLOGY

Assessing Activity and Inhibition of Middle East Respiratory Syndrome Coronavirus Papain-Like and 3C-Like Proteases Using Luciferase-Based Biosensors

(2013) A. Kilianski et al.   JOURNAL OF VIROLOGY

Infectious Bronchitis Virus Generates Spherules from Zippered Endoplasmic Reticulum Membranes

(2013) H. J. Maier et al.   mBio

Severe Acute Respiratory Syndrome Coronavirus Nonstructural Proteins 3, 4, and 6 Induce Double-Membrane Vesicles

(2013) M. M. Angelini et al.   mBio

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans

(2012) S. van Boheemen et al.   mBio

(+)RNA viruses rewire cellular pathways to build replication organelles

(2012) George A Belov et al.   Current Opinion in Virology

Three-Dimensional Architecture and Biogenesis of Membrane Structures Associated with Hepatitis C Virus Replication

(2012) Inés Romero-Brey et al.   PLoS Pathogens

Complex Dynamic Development of Poliovirus Membranous Replication Complexes

(2011) G. A. Belov et al.   JOURNAL OF VIROLOGY

Mobility and Interactions of Coronavirus Nonstructural Protein 4

(2011) M. C. Hagemeijer et al.   JOURNAL OF VIROLOGY

The dependence of viral RNA replication on co-opted host factors

(2011) Peter D. Nagy et al.   NATURE REVIEWS MICROBIOLOGY

The Transformation of Enterovirus Replication Structures: a Three-Dimensional Study of Single- and Double-Membrane Compartments

(2011) R. W. A. L. Limpens et al.   mBio

Cytoplasmic Viral Replication Complexes

(2010) Johan A. den Boon et al.   Cell Host & Microbe

Qualitative and quantitative ultrastructural analysis of the membrane rearrangements induced by coronavirus

(2010) Mustafa Ulasli et al.   CELLULAR MICROBIOLOGY

Recent Advances in Targeting Viral Proteases for the Discovery of Novel Antivirals

(2010) Holger Steuber et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Do viruses subvert cholesterol homeostasis to induce host cubic membranes?

(2010) Yuru Deng et al.   TRENDS IN CELL BIOLOGY

Murine Hepatitis Virus Nonstructural Protein 4 Regulates Virus-Induced Membrane Modifications and Replication Complex Function

(2009) M. J. Gadlage et al.   JOURNAL OF VIROLOGY

Detection of Nonstructural Protein 6 in Murine Coronavirus-Infected Cells and Analysis of the Transmembrane Topology by Using Bioinformatics and Molecular Approaches

(2009) S. Baliji et al.   JOURNAL OF VIROLOGY

Coronaviruses post-SARS: update on replication and pathogenesis

(2009) Stanley Perlman et al.   NATURE REVIEWS MICROBIOLOGY

Formation of the Arterivirus Replication/Transcription Complex: a Key Role for Nonstructural Protein 3 in the Remodeling of Intracellular Membranes

(2008) C. C. Posthuma et al.   JOURNAL OF VIROLOGY

Topology and Membrane Anchoring of the Coronavirus Replication Complex: Not All Hydrophobic Domains of nsp3 and nsp6 Are Membrane Spanning

(2008) M. Oostra et al.   JOURNAL OF VIROLOGY

Modification of intracellular membrane structures for virus replication

(2008) Sven Miller et al.   NATURE REVIEWS MICROBIOLOGY

Genome-Wide Analysis of Protein-Protein Interactions and Involvement of Viral Proteins in SARS-CoV Replication

(2008) Ji'An Pan et al.   PLoS One

Mutation in murine coronavirus replication protein nsp4 alters assembly of double membrane vesicles

(2008) Mark A. Clementz et al.   VIROLOGY

SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum

(2008) Kèvin Knoops et al.   PLOS BIOLOGY