Acetylcholinesterase inhibitors (nerve agents) as weapons of mass destruction: History, mechanisms of action, and medical countermeasures

Nanoscavenger provides long-term prophylactic protection against nerve agents in rodents

(2019) Peng Zhang et al.   Science Translational Medicine

Targeting the glutamatergic system to counteract organophosphate poisoning: A novel therapeutic strategy

(2019) Vassiliki Aroniadou-Anderjaska et al.   NEUROBIOLOGY OF DISEASE

Novel therapeutics for treating organophosphate-induced status epilepticus co-morbidities, based on changes in calcium homeostasis

(2019) Laxmikant S. Deshpande et al.   NEUROBIOLOGY OF DISEASE

Novichoks: The Dangerous Fourth Generation of Chemical Weapons

(2019) Tanos Franca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antiseizure and neuroprotective effects of delayed treatment with midazolam in a rodent model of organophosphate exposure

(2019) Jay Spampanato et al.   EPILEPSIA

In Vivo Evaluation of A1 Adenosine Agonists as Novel Anticonvulsant Medical Countermeasures to Nerve Agent Intoxication in a Rat Soman Seizure Model

(2019) Thaddeus P. Thomas et al.   NEUROTOXICITY RESEARCH

Enaminone Modulators of Extrasynaptic α4β3δ γ-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning

(2019) Timothy B. C. Johnstone et al.   Frontiers in Pharmacology

Emerging therapeutic potentials of dual‐acting MAO and AChE inhibitors in Alzheimer's and Parkinson's diseases

(2019) Bijo Mathew et al.   ARCHIV DER PHARMAZIE

Neurobiology of organophosphate-induced seizures

(2019) John Williamson et al.   EPILEPSY & BEHAVIOR

Rational polytherapy in the treatment of cholinergic seizures

(2019) Jerome Niquet et al.   NEUROBIOLOGY OF DISEASE

α‐Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionic Acid Receptor Plasticity Sustains Severe, Fatal Status Epilepticus

(2019) Nadia Adotevi et al.   ANNALS OF NEUROLOGY

Screening for Efficacious Anticonvulsants and Neuroprotectants in Delayed Treatment Models of Organophosphate-induced Status Epilepticus

(2019) Bryan S. Barker et al.   NEUROSCIENCE

Cholinesterases and the fine line between poison and remedy

(2018) Carey N. Pope et al.   BIOCHEMICAL PHARMACOLOGY

Catalytic bioscavengers as countermeasures against organophosphate nerve agents

(2018) Moshe Goldsmith et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Comparing the Antiseizure and Neuroprotective Efficacy of LY293558, Diazepam, Caramiphen, and LY293558-Caramiphen Combination against Soman in a Rat Model Relevant to the Pediatric Population

(2018) James P. Apland et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Physiological roles of CNS muscarinic receptors gained from knockout mice

(2018) Morgane Thomsen et al.   NEUROPHARMACOLOGY

Oscillatory Synchronous Inhibition in the Basolateral Amygdala and its Primary Dependence on NR2A-containing NMDA Receptors

(2018) Vassiliki Aroniadou-Anderjaska et al.   NEUROSCIENCE

Full Protection Against Soman-Induced Seizures and Brain Damage by LY293558 and Caramiphen Combination Treatment in Adult Rats

(2018) James P. Apland et al.   NEUROTOXICITY RESEARCH

Repeated exposures to diisopropylfluorophosphate result in structural disruptions of myelinated axons and persistent impairments of axonal transport in the brains of rats

(2018) Sean X. Naughton et al.   TOXICOLOGY

Gene expression analysis reveals chronic low level exposure to the pesticide diazinon affects psychological disorders gene sets in the adult rat

(2018) Claire Y. Savy et al.   TOXICOLOGY

Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents

(2018) Sofya V. Lushchekina et al.   Frontiers in Pharmacology

Chemical warfare agent NOVICHOK - mini-review of available data

(2018) Eugenie Nepovimova et al.   FOOD AND CHEMICAL TOXICOLOGY

Addition of ketamine to standard-of-care countermeasures for acute organophosphate poisoning improves neurobiological outcomes

(2018) Jeffrey David Lewine et al.   NEUROTOXICOLOGY

Neurotoxicity in acute and repeated organophosphate exposure

(2018) Sean X. Naughton et al.   TOXICOLOGY

Seizure-Induced Potentiation of AMPA Receptor-Mediated Synaptic Transmission in the Entorhinal Cortex

(2018) Dmitry V. Amakhin et al.   Frontiers in Cellular Neuroscience

Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy

(2018) Thaiane Coelho dos Santos et al.   Frontiers in Pharmacology

The synthetic neuroactive steroid SGE-516 reduces status epilepticus and neuronal cell death in a rat model of soman intoxication

(2017) Alison L. Althaus et al.   EPILEPSY & BEHAVIOR

Fatal sarin poisoning in Syria 2013: forensic verification within an international laboratory network

(2017) Harald John et al.   Forensic Toxicology

Simultaneous triple therapy for the treatment of status epilepticus

(2017) Jerome Niquet et al.   NEUROBIOLOGY OF DISEASE

Enhanced AMPA receptor-mediated neurotransmission on CA1 pyramidal neurons during status epilepticus

(2017) Suchitra Joshi et al.   NEUROBIOLOGY OF DISEASE

Susceptibility to Soman Toxicity and Efficacy of LY293558 Against Soman-Induced Seizures and Neuropathology in 10-Month-Old Male Rats

(2017) James P. Apland et al.   NEUROTOXICITY RESEARCH

Toxicogenomic profile of apoptotic and necrotic SN56 basal forebrain cholinergic neuronal loss after acute and long-term chlorpyrifos exposure

(2017) Paula Moyano et al.   NEUROTOXICOLOGY AND TERATOLOGY

Long-term neuropathological and behavioral impairments after exposure to nerve agents

(2016) Vassiliki Aroniadou-Anderjaska et al.   Annals of the New York Academy of Sciences

Oximes in organophosphate poisoning: 60 years of hope and despair

(2016) Franz Worek et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effects of toxicant exposures during deployment

(2016) Roberta F. White et al.   CORTEX

Laryngospasm, central and obstructive apnea during seizures: Defining pathophysiology for sudden death in a rat model

(2016) K. Nakase et al.   EPILEPSY RESEARCH

Cotransmission of acetylcholine and GABA

(2016) Adam J. Granger et al.   NEUROPHARMACOLOGY

Catalytic bioscavengers in nerve agent poisoning: A promising approach?

(2016) Franz Worek et al.   TOXICOLOGY LETTERS

Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies

(2016) Francisco J. Carvajal et al.   NEURAL PLASTICITY

Midazolam as an anticonvulsant antidote for organophosphate intoxication-A pharmacotherapeutic appraisal

(2015) Sandesh D. Reddy et al.   EPILEPSIA

Immunity and inflammation in status epilepticus and its sequelae: possibilities for therapeutic application

(2015) Annamaria Vezzani et al.   Expert Review of Neurotherapeutics

Organic Carbamates in Drug Design and Medicinal Chemistry

(2015) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Breathing Inhibited When Seizures Spread to the Amygdala and upon Amygdala Stimulation

(2015) B. J. Dlouhy et al.   JOURNAL OF NEUROSCIENCE

LY293558 prevents soman-induced pathophysiological alterations in the basolateral amygdala and the development of anxiety

(2015) Eric M. Prager et al.   NEUROPHARMACOLOGY

A rat model of nerve agent exposure applicable to the pediatric population: The anticonvulsant efficacies of atropine and GluK1 antagonists

(2015) Steven L. Miller et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Immunity and inflammation in status epilepticus and its sequelae: possibilities for therapeutic application

(2015) Annamaria Vezzani et al.   Expert Review of Neurotherapeutics

The Role of Excitotoxic Programmed Necrosis in Acute Brain Injury

(2015) Denson G. Fujikawa   Computational and Structural Biotechnology Journal

Respiratory Complications of Organophosphorus Nerve Agent and Insecticide Poisoning. Implications for Respiratory and Critical Care

(2014) Elspeth J. Hulse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Evaluation of Prophylactic Efficacy of Newly Developed Reversible Inhibitors of Acetylcholinesterase in Soman-Poisoned Mice - A Comparison with Commonly Used Pyridostigmine

(2014) Jiri Kassa et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Cardiotoxicity in rabbits after a low-level exposure to diazinon, propoxur, and chlorpyrifos

(2014) A Zafiropoulos et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Acute pulmonary toxicity following inhalation exposure to aerosolized VX in anesthetized rats

(2014) Xinqi Peng et al.   INHALATION TOXICOLOGY

How Is Acetylcholinesterase Phosphonylated by Soman? An Ab Initio QM/MM Molecular Dynamics Study

(2014) Gulseher Sarah Sirin et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Muscarinic acetylcholine receptors: novel opportunities for drug development

(2014) Andrew C. Kruse et al.   NATURE REVIEWS DRUG DISCOVERY

The recovery of acetylcholinesterase activity and the progression of neuropathological and pathophysiological alterations in the rat basolateral amygdala after soman-induced status epilepticus: Relation to anxiety-like behavior

(2014) Eric M. Prager et al.   NEUROPHARMACOLOGY

Extrasynaptic NMDA Receptor in Excitotoxicity

(2014) Xianju Zhou et al.   NEUROSCIENTIST

Pathophysiological mechanisms underlying increased anxiety after soman exposure: Reduced GABAergic inhibition in the basolateral amygdala

(2014) Eric M. Prager et al.   NEUROTOXICOLOGY

Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication

(2014) Laxmikant S. Deshpande et al.   NEUROTOXICOLOGY

Prolonged Administration of Pyridostigmine Impairs Neuromuscular Function with and without Down-regulation of Acetylcholine Receptors

(2013) Martina Richtsfeld et al.   ANESTHESIOLOGY

Progress in the development of enzyme-based nerve agent bioscavengers

(2013) Florian Nachon et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

(2013) Mirjana B. Colovic et al.   Current Neuropharmacology

Trafficking of NMDA receptors during status epilepticus: Therapeutic implications

(2013) Claude G. Wasterlain et al.   EPILEPSIA

Valnoctamide andsec-butyl-propylacetamide (SPD) for acute seizures and status epilepticus

(2013) Tawfeeq Shekh-Ahmad et al.   EPILEPSIA

Receptor trafficking hypothesis revisited: Plasticity of AMPA receptors during established status epilepticus

(2013) Karthik Rajasekaran et al.   EPILEPSIA

Acetylcholinesterase inhibitors as Alzheimer therapy: From nerve toxins to neuroprotection

(2013) Manjinder Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study

(2013) Vendula Sepsova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Syrian gas attack reinforces need for better anti-sarin drugs

(2013) Elie Dolgin   NATURE MEDICINE

Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus

(2013) David E. Naylor et al.   NEUROBIOLOGY OF DISEASE

Acetylcholinesterase inhibition in the basolateral amygdala plays a key role in the induction of status epilepticus after soman exposure

(2013) Eric M. Prager et al.   NEUROTOXICOLOGY

Central respiratory failure during acute organophosphate poisoning

(2013) Jennifer L. Carey et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Anticholinesterase insecticide retrospective

(2012) John E. Casida et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Ketamine combinations for the field treatment of soman-induced self-sustaining status epilepticus. Review of current data and perspectives

(2012) Frederic Dorandeu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Possible alterations in GABAAreceptor signaling that underlie benzodiazepine-resistant seizures

(2012) Tarek Z. Deeb et al.   EPILEPSIA

Benzodiazepines Modulate GABAA Receptors by Regulating the Preactivation Step after GABA Binding

(2012) M. C. Gielen et al.   JOURNAL OF NEUROSCIENCE

Aging Mechanism of Soman Inhibited Acetylcholinesterase

(2012) Gulseher Sarah Sirin et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Exposure to nerve agents: From status epilepticus to neuroinflammation, brain damage, neurogenesis and epilepsy

(2012) Marcio de Araujo Furtado et al.   NEUROTOXICOLOGY

A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation

(2012) Christopher N. Banks et al.   NEUROTOXICOLOGY

Functional consequences of repeated organophosphate exposure: Potential non-cholinergic mechanisms

(2012) A.V. Terry   PHARMACOLOGY & THERAPEUTICS

Histopathological lesions, oxidative stress and genotoxic effects in liver and kidneys following long term exposure of rabbits to diazinon and propoxur

(2012) Christina Tsitsimpikou et al.   TOXICOLOGY

Advances in toxicology and medical treatment of chemical warfare nerve agents

(2012) Mohammd Moshiri et al.   DARU-Journal of Pharmaceutical Sciences

Long-term effects of cytokine treatment on cognitive behavioral recovery and neuronal regeneration in soman-poisoned mice

(2011) Jean-Marc Collombet et al.   BEHAVIOURAL BRAIN RESEARCH

Neuroprotective efficacy of caramiphen against soman and mechanisms of its action

(2011) TH Figueiredo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Emerging Pharmacological Properties of Cholinergic Synaptic Transmission: Comparison between Mammalian and Insect Synaptic and Extrasynaptic Nicotinic Receptors

(2011) Steeve H. Thany et al.   Current Neuropharmacology

Habenula “Cholinergic” Neurons Corelease Glutamate and Acetylcholine and Activate Postsynaptic Neurons via Distinct Transmission Modes

(2011) Jing Ren et al.   NEURON

Galantamine counteracts development of learning impairment in guinea pigs exposed to the organophosphorus poison soman: Clinical significance

(2011) Jacek Mamczarz et al.   NEUROTOXICOLOGY

Cholinergic Interneurons Mediate Fast VGluT3-Dependent Glutamatergic Transmission in the Striatum

(2011) Michael J. Higley et al.   PLoS One

Molecular and cellular mechanisms of excitotoxic neuronal death

(2010) Yan Wang et al.   APOPTOSIS

Spontaneous recurrent seizures after status epilepticus induced by soman in Sprague-Dawley rats

(2010) Marcio De Araujo Furtado et al.   EPILEPSIA

The GluK1 (GluR5) Kainate/ -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Antagonist LY293558 Reduces Soman-Induced Seizures and Neuropathology

(2010) T. H. Figueiredo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Reduced amygdalar and hippocampal size in adults with generalized social phobia

(2010) Eva Irle   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Higher susceptibility of the ventral versus the dorsal hippocampus and the posteroventral versus anterodorsal amygdala to soman-induced neuropathology☆

(2010) James P. Apland et al.   NEUROTOXICOLOGY

Acetylcholinesterase inhibitors and memantine for neuroenhancement in healthy individuals: A systematic review

(2010) Dimitris Repantis et al.   PHARMACOLOGICAL RESEARCH

Mice Treated with Chlorpyrifos or Chlorpyrifos Oxon Have Organophosphorylated Tubulin in the Brain and Disrupted Microtubule Structures, Suggesting a Role for Tubulin in Neurotoxicity Associated with Exposure to Organophosphorus Agents

(2010) Wei Jiang et al.   TOXICOLOGICAL SCIENCES

Central cholinergic regulation of respiration: nicotinic receptors

(2009) Xuesi M Shao et al.   ACTA PHARMACOLOGICA SINICA

Structural and functional diversity of native brain neuronal nicotinic receptors

(2009) Cecilia Gotti et al.   BIOCHEMICAL PHARMACOLOGY

Respiratory Physiology of Seizures

(2009) Andrew S. Blum   JOURNAL OF CLINICAL NEUROPHYSIOLOGY

Primary brain targets of nerve agents: The role of the amygdala in comparison to the hippocampus

(2009) Vassiliki Aroniadou-Anderjaska et al.   NEUROTOXICOLOGY

Case report: Long-term cognitive sequelae of sarin exposure

(2009) Yince Loh et al.   NEUROTOXICOLOGY

Roles of perirhinal and posterior piriform cortices in control and generation of seizures: A microinfusion study in rats exposed to soman

(2009) Trond Myhrer et al.   NEUROTOXICOLOGY

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

Smaller amygdala volume and reduced anterior cingulate gray matter density associated with history of post-traumatic stress disorder

(2009) Mark A. Rogers et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: A potential mechanism of long term toxicity by organophosphorus agents

(2008) Hasmik Grigoryan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Pathology and pathophysiology of the amygdala in epileptogenesis and epilepsy

(2008) Vassiliki Aroniadou-Anderjaska et al.   EPILEPSY RESEARCH

The Long-Term Psychosocial Impact of a Surprise Chemical Weapons Attack on Civilians in Halabja, Iraqi Kurdistan

(2008) Jonathan Dworkin et al.   JOURNAL OF NERVOUS AND MENTAL DISEASE

Subunit-Specific Trafficking of GABAA Receptors during Status Epilepticus

(2008) H. P. Goodkin et al.   JOURNAL OF NEUROSCIENCE

Kainate receptors: Pharmacology, function and therapeutic potential

(2008) David E. Jane et al.   NEUROPHARMACOLOGY

Soman induces ictogenesis in the amygdala and interictal activity in the hippocampus that are blocked by a GluR5 kainate receptor antagonist in vitro

(2008) J.P. Apland et al.   NEUROSCIENCE

Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning

(2008) Marloes J.A. Joosen et al.   NEUROTOXICOLOGY

Mechanism of action of benzodiazepines on GABAA receptors

(2006) Claudia Campo-Soria et al.   BRITISH JOURNAL OF PHARMACOLOGY