Article
Critical Care Medicine
Anna Lybeck, Hans Friberg, Niklas Nielsen, Malin Rundgren, Susann Ullen, Henrik Zetterberg, Kaj Blennow, Tobias Cronberg, Erik Westhall
Summary: The study found that patients who developed electrographic status epilepticus (ESE) after cardiac arrest had higher levels of serum NfL at 72 hours post-arrest, suggesting increased secondary neuronal injury compared to matched patients without ESE. Associations with GFAP reflecting glial injury were less clear in this study. The design of the study could not exclude imperfect matching or other mechanisms contributing to the higher levels of biomarkers of brain injury seen in patients with ESE.
Article
Clinical Neurology
Haiyu Liu, Liang Zhang
Summary: Seizure clusters are common in epileptic patients and are associated with an increased risk of developing status epilepticus and higher morbidity and mortality rates. Through an experiment involving hippocampal kindling in mice, it was found that seizure clustering represents a prominent feature of spontaneous recurrent seizures, showing variable patterns between individual mice. Despite limitations, systemic homeostatic mechanisms may play a crucial role in governing the occurrence and termination of seizure clusters.
FRONTIERS IN NEUROLOGY
(2021)
Article
Behavioral Sciences
Adithya Sivaraju, Lawrence J. Hirsch
Summary: Status epilepticus is a serious medical condition with poor outcomes. There are several scores available to predict outcomes, but their utility in real-time clinical care is unclear. EEG findings are important for accurate prognostication. In the pediatric population, the only available scale is PEDSS.
EPILEPSY & BEHAVIOR
(2023)
Article
Veterinary Sciences
Patrick Roynard, Ann Bilderback, Curtis Wells Dewey
Summary: Ketamine 5 mg/kg IV bolus may be successful in treating RSE in dogs, but its efficacy in handling CS is limited. The incidence of adverse effects is low, but timing of administration should be carefully considered.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Critical Care Medicine
Samuel Snider, Michael W. K. M. Fong, Neal Nolan, Andres Rodriguez Ruiz, Wei Wang, Suzette LaRoche, Lawrence Hirsch, Jong Lee
Summary: This study aimed to identify clinical diagnoses and rhythmic and periodic electroencephalogram patterns (RPPs) associated with status epilepticus (SE) and seizures. Factors independently associated with SE included cardiac arrest, clinical seizures before continuous electroencephalogram (cEEG), brain neoplasms, and specific EEG patterns. These findings are important for tailoring cEEG monitoring for critically ill patients.
CRITICAL CARE MEDICINE
(2023)
Article
Behavioral Sciences
Anya Zahra, Yuqing Sun, Nancy Aloysius, Liang Zhang
Summary: In the extended hippocampal kindling mouse model, seizures mainly manifest as generalized motor seizures, are not significantly influenced by light cycles, and are preceded by inactive behaviors. These findings suggest that ambient cage behaviors play a significant role in influencing spontaneous recurrent seizures in rodent models of temporal lobe epilepsy.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Michael C. Jin, Jonathon J. Parker, Michael Zhang, Zack A. Medress, Casey H. Halpern, Gordon Li, John K. Ratliff, Gerald A. Grant, Robert S. Fisher, Stephen Skirboll
Summary: The occurrence of early and late PNSE was associated with specific neurosurgical pathologies and increased mortality. These findings provide a foundation for validating clinical and perioperative risk factors prospectively and help identify patients who require heightened diagnostic suspicion for PNSE.
JOURNAL OF NEUROSURGERY
(2021)
Review
Pharmacology & Pharmacy
Pablo Bravo, Aparna Vaddiparti, Lawrence J. Hirsch
Summary: Most seizures in critically ill patients are nonconvulsive, often complicating conditions like brain infections, hemorrhages, global hypoxia, sepsis, and recent neurosurgery. Early recognition through continuous EEG monitoring is crucial to prevent adverse neurological outcomes from prolonged nonconvulsive seizures. Limited evidence exists on pharmacotherapy for nonconvulsive seizures and nonconvulsive status epilepticus, but prompt management with antiseizure medications can prevent refractoriness and further neurological injury.
Article
Oncology
Sophie von Brauchitsch, Adam Strzelczyk, Felix Rosenow, Elisabeth Neuhaus, Daniel Dubinski, Joachim P. Steinbach, Martin Voss
Summary: This study accurately analyzed the incidence of epileptic seizures at the end of life in brain tumor patients using clinical and electrophysiological findings. The results showed a higher occurrence of seizures and status epilepticus in neurooncological patients compared to previous reports.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Clinical Neurology
Tian Sang, Ying Wang, Ye Wu, Qiao Guan, ZhiXian Yang
Summary: This study investigated the neonatal electroencephalography background activity and electrographic seizures in patients in the pediatric intensive care unit. It found that more than one-third of patients experienced electrographic seizures, and abnormal EEG background activity was associated with unfavorable in-hospital outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Review
Anesthesiology
I. Migdady, E. S. Rosenthal, H. R. Cock
Summary: Status epilepticus is a condition characterized by prolonged or repetitive seizures that can result in serious complications if left untreated. Early seizure control is crucial in preventing these complications, especially for convulsive status epilepticus. However, there is still debate regarding the goals and aggressiveness of therapy, particularly for non-convulsive status epilepticus.
Article
Neurosciences
Efrat Shavit-Stein, Shani Berkowitz, Tal Davidy, Uri Fennig, Shani Guly Gofrit, Amir Dori, Nicola Maggio
Summary: This study evaluated the effects of thrombin pathway inhibition in a mice model of SE and found that thrombin is involved in memory impairment and cognitive dysfunction. Inhibiting the thrombin pathway can prevent cognitive impairment and reduce neuronal damage.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Clinical Neurology
Helene Fenter, Andrea O. Rossetti, Isabelle Beuchat
Summary: Electroencephalography (EEG) is a crucial tool in the ICU for detecting seizures, evaluating prognosis of comatose patients, and detecting delayed ischemia. Continuous EEG (cEEG) has been increasingly adopted, but the widespread recommendation for its use is still debated.
EUROPEAN NEUROLOGY
(2023)
Article
Clinical Neurology
Elena Merli, Michele Romoli, Simone Galluzzo, Lorenzo Bevacqua, Emanuele Saverio Cece, Gabriele Ricci, Stefania Testoni, Anna Zaniboni, Maria Maddalena Viola, Luigi Simonetti, Francesca Bisulli, Sara Contardi, Paolo Tinuper, Andrea Zini
Summary: This study demonstrated the accuracy of CTP in identifying non-convulsive status epilepticus (NCSE), potentially serving as part of a pragmatic diagnostic workflow. CTP hyperperfusion showed a high negative predictive value for the diagnosis of NCSE, with further validation studies needed to evaluate its real-world application in NCSE cases.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Neurosciences
Konrad Rejdak, Agata Pikulicka, Malgorzata Piekarska, Katarzyna Pacek, Kamila Plachta
Summary: Status epilepticus is a severe neurological disease characterized by prolonged seizures and loss of consciousness. Inflammation, particularly in cases of new onset refractory status epilepticus, has been identified as a potential cause. Research suggests that drugs with anti-inflammatory properties may be effective in treating status epilepticus, with promising results in new-onset refractory cases.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Victoria L. Nutsch, Ryan G. Will, Christopher L. Robison, Julia R. Martz, Daniel J. Tobiansky, Juan M. Dominguez
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2016)
Article
Psychology, Biological
Christopher L. Robison, Jenna A. McHenry, Elaine M. Hull
PHYSIOLOGY & BEHAVIOR
(2017)
Article
Biochemical Research Methods
Marcio de Araujo Furtado, Andy Zheng, Madineh Sedigh-Sarvestani, Lucille Lumley, Spencer Lichtenstein, Debra Yourick
JOURNAL OF NEUROSCIENCE METHODS
(2009)
Article
Toxicology
Jose M. Pizarro, Wenling E. Chang, Mariama J. Bah, Linnzi K. M. Wright, George A. Saviolakis, Arun Alagappan, Christopher L. Robison, Jinesh D. Shah, James L. Meyerhoff, Douglas M. Cerasoli, Eric G. Midboe, Lucille A. Lumley
TOXICOLOGICAL SCIENCES
(2012)
Article
Neurosciences
JM Pizarro, LA Lumley, W Medina, CL Robison, WLE Chang, A Alagappan, MJ Bah, MY Dawood, JD Shah, B Mark, N Kendall, MA Smith, GA Saviolakis, JL Meyerhoff
Article
Neurosciences
LA Lumley, CL Robison, BS Slusher, K Wozniak, M Dawood, JL Meyerhoff
PSYCHOPHARMACOLOGY
(2004)
Article
Psychology, Biological
LA Lumley, CL Robison, WK Chen, B Mark, JL Meyerhoff
PHYSIOLOGY & BEHAVIOR
(2001)