Advances in toxicology and medical treatment of chemical warfare nerve agents

Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

(2012) Guillaume Mercey et al.   ACCOUNTS OF CHEMICAL RESEARCH

Combinations of ketamine and atropine are neuroprotective and reduce neuroinflammation after a toxic status epilepticus in mice

(2012) Franck Dhote et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Long-term effects of cytokine treatment on cognitive behavioral recovery and neuronal regeneration in soman-poisoned mice

(2011) Jean-Marc Collombet et al.   BEHAVIOURAL BRAIN RESEARCH

Comparison of Status Epilepticus Models Induced by Pilocarpine and Nerve Agents - A Systematic Review of the Underlying Aetiology and Adopted Therapeutic Approaches

(2011) F. R. Tang et al.   CURRENT MEDICINAL CHEMISTRY

Biomarkers of organophosphorus (OP) exposures in humans

(2011) Judit Marsillach et al.   NEUROTOXICOLOGY

Wide Complex Tachycardia in a Pediatric Diphenhydramine Overdose Treated With Sodium Bicarbonate

(2011) Jon B. Cole et al.   PEDIATRIC EMERGENCY CARE

A comprehensive review on experimental and clinical findings in intermediate syndrome caused by organophosphate poisoning

(2011) Mohammad Abdollahi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Post-exposure therapy with recombinant human BuChE following percutaneous VX challenge in guinea-pigs

(2011) Helen Mumford et al.   TOXICOLOGY LETTERS

Evolution of and perspectives on therapeutic approaches to nerve agent poisoning

(2011) Patrick Masson   TOXICOLOGY LETTERS

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for detection and identification of albumin phosphylation by organophosphorus pesticides and G- and V-type nerve agents

(2010) Harald John et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Visualization of exogenous delivery of nanoformulated butyrylcholinesterase to the central nervous system

(2010) Andrea Gaydess et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Direct detection of the hydrolysis of nerve agent model compounds using a fluorescent probe

(2010) Xueying Zheng et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Percutaneous exposure to the nerve agent VX: Efficacy of combined atropine, obidoxime and diazepam treatment

(2010) Marloes J.A. Joosen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Organophosphate induced delayed polyneuropathy in man: An overview

(2010) Milan Jokanović et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048)in vivodetected by biochemical and histochemical techniques

(2010) Jiri Bajgar et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The GluK1 (GluR5) Kainate/ -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Antagonist LY293558 Reduces Soman-Induced Seizures and Neuropathology

(2010) T. H. Figueiredo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The oxime pro-2-PAM provides minimal protection against the CNS effects of the nerve agents sarin, cyclosarin, and VX in guinea pigs

(2010) Tsung-Ming Shih et al.   TOXICOLOGY MECHANISMS AND METHODS

Intravenous lipid emulsion in clinical toxicology

(2010) Leelach Rothschild et al.   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

Reactivation of Human Brain Homogenate Cholinesterases Inhibited by Tabun using Newly Developed Oximes K117 and K127

(2009) Kamil Kuca et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Interaction of Monotopic Membrane Enzymes with a Lipid Bilayer: A Coarse-Grained MD Simulation Study†

(2009) Kia Balali-Mood et al.   BIOCHEMISTRY

Chemical Aspects of Pharmacological Prophylaxis Against Nerve Agent Poisoning

(2009) Jiri Bajgar et al.   CURRENT MEDICINAL CHEMISTRY

GC–MS and LC–MS analysis of nerve agents in body fluids: Intra-laboratory verification test using spiked plasma and urine samples

(2009) Marianne Koller et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

History and perspectives of bioanalytical methods for chemical warfare agent detection

(2009) Robin M. Black   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Effectiveness of Donepezil, Rivastigmine, and ( )Huperzine A in Counteracting the Acute Toxicity of Organophosphorus Nerve Agents: Comparison with Galantamine

(2009) Y. Aracava et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Intravenous lipid emulsions combine extracorporeal blood purification: A novel therapeutic strategy for severe organophosphate poisoning

(2009) Yaguang Zhou et al.   MEDICAL HYPOTHESES

Detoxification of nerve agents by a substituted β-cyclodextrin: Application of a modified biological assay

(2009) T. Wille et al.   TOXICOLOGY

Acute renal failure enhances the antidotal activity of pralidoxime towards paraoxon-induced respiratory toxicity

(2009) Maya Kayouka et al.   TOXICOLOGY LETTERS

Current understanding of the mechanisms involved in metabolic detoxification of warfare nerve agents

(2009) Milan Jokanović   TOXICOLOGY LETTERS

Medical treatment of acute poisoning with organophosphorus and carbamate pesticides

(2009) Milan Jokanović   TOXICOLOGY LETTERS

Organophosphorus-induced delayed neuropathy: A simple and efficient therapeutic strategy

(2009) Guilherme L. Emerick et al.   TOXICOLOGY LETTERS

Decontamination of Chemical and Biological Warfare Agents

(2009) Yasuo SETO   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

[+]-Huperzine A treatment protects against N-methyl-d-aspartate-induced seizure/status epilepticus in rats

(2008) Brian R. Coleman et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats

(2008) Jiri Kassa et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Carbon Nanotube-Based Electrochemical Sensor for Assay of Salivary Cholinesterase Enzyme Activity: An Exposure Biomarker of Organophosphate Pesticides and Nerve Agents

(2008) Jun Wang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Degradation of nerve agents by an organophosphate-degrading agent (OpdA)

(2008) R.M. Dawson et al.   JOURNAL OF HAZARDOUS MATERIALS

The Development of New Oximes and the Evaluation of their Reactivating, Therapeutic and Neuroprotective Efficacy Against Tabun

(2008) Jiri Kassa et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Acute renal failure alters the kinetics of pralidoxime in rats

(2008) Maya Kayouka et al.   TOXICOLOGY LETTERS

A Comparison of the Potency of Newly Developed Oximes (K074, K075) and Currently Available Oximes (Obidoxime, Trimedoxime, Hi-6) to Counteract Acute Toxic Effects of Tabun and Cyclosarin in Mice

(2007) Jiří Kassa et al.   DRUG AND CHEMICAL TOXICOLOGY

Management of acute organophosphorus pesticide poisoning

(2007) Michael Eddleston et al.   LANCET

Single whole-body exposure to sarin vapor in rats: Long-term neuronal and behavioral deficits

(2007) Ettie Grauer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY