Immunity and inflammation in status epilepticus and its sequelae: possibilities for therapeutic application

Status Epilepticus

(2015) Nicola A. Marchi et al.   CRITICAL CARE MEDICINE

New-onset refractory status epilepticus (NORSE) — The potential role for immunotherapy

(2015) Ayaz M. Khawaja et al.   EPILEPSY & BEHAVIOR

Anti-inflammatory drugs in epilepsy: does it impact epileptogenesis?

(2015) Annamaria Vezzani   Expert Opinion On Drug Safety

A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models

(2015) Melissa J. Benson et al.   NEUROBIOLOGY OF DISEASE

Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus

(2015) Jianxiong Jiang et al.   NEUROBIOLOGY OF DISEASE

Status epilepticus of inflammatory etiology

(2015) Marianna Spatola et al.   NEUROLOGY

Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus

(2015) Asheebo Rojas et al.   NEUROPHARMACOLOGY

Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability

(2015) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus

(2015) N. Wang et al.   NEUROSCIENCE

Blood–brain barrier dysfunction, seizures and epilepsy

(2015) E.A. van Vliet et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity

(2014) Marc-André Bellavance et al.   Brain Structure & Function

Evaluation of a clinical tool for early etiology identification in status epilepticus

(2014) Vincent Alvarez et al.   EPILEPSIA

Lovastatin decreases the synthesis of inflammatory mediators during epileptogenesis in the hippocampus of rats submitted to pilocarpine-induced epilepsy

(2014) T.L.F. Gouveia et al.   EPILEPSY & BEHAVIOR

Ketogenic diet in pediatric patients with refractory focal status epilepticus

(2014) Roberto Horacio Caraballo et al.   EPILEPSY RESEARCH

Statins are associated with decreased mortality risk after status epilepticus

(2014) A. Sierra-Marcos et al.   EUROPEAN JOURNAL OF NEUROLOGY

Autoimmunity and inflammation in status epilepticus: from concepts to therapies

(2014) Franz Josef Holzer et al.   Expert Review of Neurotherapeutics

What’s new in status epilepticus?

(2014) Andrea O. Rossetti et al.   INTENSIVE CARE MEDICINE

Intrathecal overproduction of proinflammatory cytokines and chemokines in febrile infection-related refractory status epilepticus

(2014) Hiroshi Sakuma et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

A Novel, Noninvasive, Predictive Epilepsy Biomarker with Clinical Potential

(2014) M. Choy et al.   JOURNAL OF NEUROSCIENCE

The Epidemiology of Status Epilepticus in the United States

(2014) Bhavpreet S. Dham et al.   Neurocritical Care

Ketogenic diet for adults in super-refractory status epilepticus

(2014) K. T. Thakur et al.   NEUROLOGY

Status Epilepticus: Immunologic and Inflammatory Mechanisms

(2014) Chandrabhaga Miskin et al.   Seminars in Pediatric Neurology

Nrf2 defense pathway: Experimental evidence for its protective role in epilepsy

(2013) Manuela Mazzuferi et al.   ANNALS OF NEUROLOGY

Hippocampal sclerosis after febrile status epilepticus: The FEBSTAT study

(2013) Darrell V. Lewis et al.   ANNALS OF NEUROLOGY

Increased excitability and molecular changes in adult rats after a febrile seizure

(2013) Aylin Y. Reid et al.   EPILEPSIA

Intravenous ketamine for the treatment of refractory status epilepticus: A retrospective multicenter study

(2013) Nicolas Gaspard et al.   EPILEPSIA

Treatment of convulsive status epilepticus in childhood: Recommendations of the Italian League Against Epilepsy

(2013) Giuseppe Capovilla et al.   EPILEPSIA

Cyclooxygenase-2 in epilepsy

(2013) Asheebo Rojas et al.   EPILEPSIA

Ketamine use in the treatment of refractory status epilepticus

(2013) Andrea S. Synowiec et al.   EPILEPSY RESEARCH

Expressions of Tumor Necrosis Factor Alpha and MicroRNA-155 in Immature Rat Model of Status Epilepticus and Children with Mesial Temporal Lobe Epilepsy

(2013) Muhammad Usman Ashhab et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Immunological perspectives of temporal lobe seizures

(2013) Suvi Liimatainen et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain

(2013) Young Se Kwon et al.   Journal of Neuroinflammation

Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study

(2013) Maarten J Titulaer et al.   LANCET NEUROLOGY

Outcome predictors for status epilepticus—what really counts

(2013) Raoul Sutter et al.   Nature Reviews Neurology

Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy

(2013) F.M. Noe et al.   NEUROBIOLOGY OF DISEASE

Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures

(2013) Valentina Iori et al.   NEUROBIOLOGY OF DISEASE

Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus

(2013) B.A. Duffy et al.   NEUROBIOLOGY OF DISEASE

Anesthetic drugs in status epilepticus: Risk or rescue?: A 6-year cohort study

(2013) R. Sutter et al.   NEUROLOGY

Successful surgical treatment of an inflammatory lesion associated with new-onset refractory status epilepticus

(2013) Csaba Juhász et al.   Neurosurgical Focus

Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation

(2013) Jianxiong Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue

(2013) Katharina Pernhorst et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection

(2013) Jianxiong Jiang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulation of HMGB1 release by inflammasomes

(2013) Ben Lu et al.   Protein & Cell

Predictors of Outcome in Refractory Status Epilepticus

(2013) Sara E. Hocker et al.   JAMA Neurology

Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage

(2012) Laura Librizzi et al.   ANNALS OF NEUROLOGY

Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis

(2012) C. G. Bien et al.   BRAIN

Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats

(2012) Lei Ma et al.   BRAIN RESEARCH

Newer antiepileptic drugs in the treatment of status epilepticus: Impact on prognosis

(2012) Léonore Jaques et al.   EPILEPSY & BEHAVIOR

Treatment of status epilepticus in a large community hospital

(2012) Christoph Kellinghaus et al.   EPILEPSY & BEHAVIOR

Antibody-Mediated Status Epilepticus: A Retrospective Multicenter Survey

(2012) Franz Josef Holzer et al.   EUROPEAN NEUROLOGY

Astrocyte immune responses in epilepsy

(2012) Eleonora Aronica et al.   GLIA

Treatment deviating from guidelines does not influence status epilepticus prognosis

(2012) Andrea O. Rossetti et al.   JOURNAL OF NEUROLOGY

The role of inflammation in epileptogenesis

(2012) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model

(2012) Fei Gao et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Status epilepticus-induced pathologic plasticity in a rat model of focal cortical dysplasia

(2011) Francesca Colciaghi et al.   BRAIN

The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol

(2011) S. Shorvon et al.   BRAIN

IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures

(2011) Annamaria Vezzani et al.   BRAIN BEHAVIOR AND IMMUNITY

Autoimmune epilepsies

(2011) Sarosh R Irani et al.   CURRENT OPINION IN NEUROLOGY

Atorvastatin treatment during epileptogenesis in a rat model for temporal lobe epilepsy

(2011) Erwin A. van Vliet et al.   EPILEPSIA

Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy

(2011) Fabien Pernot et al.   EPILEPSIA

Inflammation in epilepsy: Clinical observations

(2011) Eleonora Aronica et al.   EPILEPSIA

High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products

(2011) Andréy Mazarati et al.   EXPERIMENTAL NEUROLOGY

Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures

(2011) Jieun Choi et al.   Journal of Neuroinflammation

Ablation of Cyclooxygenase-2 in Forebrain Neurons is Neuroprotective and Dampens Brain Inflammation after Status Epilepticus

(2011) G. E. Serrano et al.   JOURNAL OF NEUROSCIENCE

Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy

(2011) M. Zattoni et al.   JOURNAL OF NEUROSCIENCE

Management of refractory status epilepticus in adults: still more questions than answers

(2011) Andrea O Rossetti et al.   LANCET NEUROLOGY

Efficacy of Anti-Inflammatory Therapy in a Model of Acute Seizures and in a Population of Pediatric Drug Resistant Epileptics

(2011) Nicola Marchi et al.   PLoS One

Administration of Simvastatin after Kainic Acid-Induced Status Epilepticus Restrains Chronic Temporal Lobe Epilepsy

(2011) Chuncheng Xie et al.   PLoS One

The effects of age on lipopolysaccharide-induced cognitive deficits and interleukin-1β expression

(2010) Andrew J. Tarr et al.   BEHAVIOURAL BRAIN RESEARCH

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Febrile infection-related epilepsy syndrome (FIRES): A nonencephalitic encephalopathy in childhood

(2010) Andreas Van Baalen et al.   EPILEPSIA

Role of immune molecules in the establishment and plasticity of glutamatergic synapses

(2010) Lawrence Fourgeaud et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy

(2010) Nadine Polascheck et al.   EXPERIMENTAL NEUROLOGY

Epileptogenesis Provoked by Prolonged Experimental Febrile Seizures: Mechanisms and Biomarkers

(2010) C. M. Dube et al.   JOURNAL OF NEUROSCIENCE

Acute encephalopathy with inflammation-mediated status epilepticus

(2010) Rima Nabbout et al.   LANCET NEUROLOGY

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Inflammation enhances epileptogenesis in the developing rat brain

(2010) Stéphane Auvin et al.   NEUROBIOLOGY OF DISEASE

A Randomized Trial for the Treatment of Refractory Status Epilepticus

(2010) Andrea O. Rossetti et al.   Neurocritical Care

Increased serum levels of high mobility group box 1 protein in patients with autistic disorder

(2010) Enzo Emanuele et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The role of interleukin-1β in febrile seizures

(2009) James G. Heida et al.   BRAIN & DEVELOPMENT

Differential monocyte responses to TLR ligands in children with autism spectrum disorders

(2009) Amanda M. Enstrom et al.   BRAIN BEHAVIOR AND IMMUNITY

Basic mechanisms of status epilepticus due to infection and inflammation

(2009) Annamaria Vezzani et al.   EPILEPSIA

The epileptic hypothesis: Developmentally related arguments based on animal models

(2009) Aristea S. Galanopoulou et al.   EPILEPSIA

Refractory status epilepticus: A prospective observational study

(2009) Jan Novy et al.   EPILEPSIA

Treatment of Rasmussen encephalitis half a century after its initial description: Promising prospects and a dilemma

(2009) Christian G. Bien et al.   EPILEPSY RESEARCH

EFNS guideline on the management of status epilepticus in adults

(2009) H. Meierkord et al.   EUROPEAN JOURNAL OF NEUROLOGY

Cellular injury and neuroinflammation in children with chronic intractable epilepsy

(2009) Jieun Choi et al.   Journal of Neuroinflammation

Age-dependent vascular changes induced by status epilepticus in rat forebrain: Implications for epileptogenesis

(2009) Jessica Marcon et al.   NEUROBIOLOGY OF DISEASE

Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats

(2009) M.A. Galic et al.   NEUROBIOLOGY OF DISEASE

Psychiatric Comorbidities in Epilepsy: Identification and Treatment

(2009) Irene García-Morales et al.   NEUROLOGIST

Immune Influence on Adult Neural Stem Cell Regulation and Function

(2009) Pamela A. Carpentier et al.   NEURON

The Stressed CNS: When Glucocorticoids Aggravate Inflammation

(2009) Shawn F. Sorrells et al.   NEURON

Erythropoietin reduces epileptogenic processes following status epilepticus

(2008) Kon Chu et al.   EPILEPSIA

Status epilepticus: Clinical presentation, cause, outcome, and predictors of death in 119 Ethiopian patients

(2008) Amanuel Amare et al.   EPILEPSIA

Ketamine successfully terminates malignant status epilepticus

(2008) Harald Prüss et al.   EPILEPSY RESEARCH

Neonatal inflammation produces selective behavioural deficits and alters N-methyl-d-aspartate receptor subunit mRNA in the adult rat brain

(2008) E.-M. Harré et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Interleukin-1 (IL-1): A central regulator of stress responses

(2008) Inbal Goshen et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Postnatal Inflammation Increases Seizure Susceptibility in Adult Rats

(2008) M. A. Galic et al.   JOURNAL OF NEUROSCIENCE

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

(2008) Paolo F Fabene et al.   NATURE MEDICINE

Antagonism of peripheral inflammation reduces the severity of status epilepticus

(2008) Nicola Marchi et al.   NEUROBIOLOGY OF DISEASE

Innate and adaptive immunity during epileptogenesis and spontaneous seizures: Evidence from experimental models and human temporal lobe epilepsy

(2007) Teresa Ravizza et al.   NEUROBIOLOGY OF DISEASE