Structure and function relationships in mammalian DNA polymerases

2.0 Å resolution crystal structure of human polκ reveals a new catalytic function of N-clasp in DNA replication

(2018) Vikash Jha et al.   Scientific Reports

Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery

(2018) Peter Tonzi et al.   eLife

DNA polymerases in the mitochondria A critical review of the evidence

(2017) William C Copeland   Frontiers in Bioscience-Landmark

Crystal structure of the human Polϵ B-subunit in complex with the C-terminal domain of the catalytic subunit

(2017) Andrey G. Baranovskiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Time-Dependent Extension from an 8-Oxoguanine Lesion by Human DNA Polymerase Beta

(2017) Andrew J. Reed et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA polymerase beta participates in DNA End-joining

(2017) Sreerupa Ray et al.   NUCLEIC ACIDS RESEARCH

Capturing a mammalian DNA polymerase extending from an oxidized nucleotide

(2017) Amy M. Whitaker et al.   NUCLEIC ACIDS RESEARCH

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu

(2017) Andrea F. Moon et al.   NUCLEIC ACIDS RESEARCH

The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport

(2017) Elizabeth O’Brien et al.   SCIENCE

Time-lapse crystallography snapshots of a double-strand break repair polymerase in action

(2017) Joonas A. Jamsen et al.   Nature Communications

Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase

(2017) Olga Rechkoblit et al.   Nature Communications

Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases

(2017) Ryan Barnes et al.   Genes

Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis

(2016) Yulia Pustovalova et al.   BIOCHEMISTRY

DNA polymerase θ (POLQ), double-strand break repair, and cancer

(2016) Richard D. Wood et al.   DNA REPAIR

Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome

(2016) Andrey G. Baranovskiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics

(2016) Dmitry M. Korzhnev et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Insights into the Post-Chemistry Steps of Nucleotide Incorporation Catalyzed by a DNA Polymerase

(2016) Andrew J. Reed et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Who Is Leading the Replication Fork, Pol ε or Pol δ?

(2016) Peter M.J. Burgers et al.   MOLECULAR CELL

DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis

(2016) Petro Starokadomskyy et al.   NATURE IMMUNOLOGY

Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ

(2016) Vikash Jha et al.   NUCLEIC ACIDS RESEARCH

Capture of a third Mg2+ is essential for catalyzing DNA synthesis

(2016) Y. Gao et al.   SCIENCE

Structural Basis for a New Templated Activity by Terminal Deoxynucleotidyl Transferase: Implications for V(D)J Recombination

(2016) Jérôme Loc'h et al.   STRUCTURE

DNA Polymerases Divide the Labor of Genome Replication

(2016) Scott A. Lujan et al.   TRENDS IN CELL BIOLOGY

Structure and mechanism of human PrimPol, a DNA polymerase with primase activity

(2016) O. Rechkoblit et al.   Science Advances

Human DNA polymerase α in binary complex with a DNA:DNA template-primer

(2016) Javier Coloma et al.   Scientific Reports

Eukaryotic Mismatch Repair in Relation to DNA Replication

(2015) Thomas A. Kunkel et al.   Annual Review of Genetics

New structural snapshots provide molecular insights into the mechanism of high fidelity DNA synthesis

(2015) Bret D. Freudenthal et al.   DNA REPAIR

Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair

(2015) J. Gouge et al.   EMBO JOURNAL

Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase

(2015) M. R. Szymanski et al.   EMBO JOURNAL

Base Excision Repair in the Mitochondria

(2015) Aishwarya Prakash et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Viewing Human DNA Polymerase β Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography

(2015) Rajan Vyas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reconsidering DNA Polymerases at the Replication Fork in Eukaryotes

(2015) Bruce Stillman   MOLECULAR CELL

A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands

(2015) Robert E. Johnson et al.   MOLECULAR CELL

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

DNA replication origin activation in space and time

(2015) Michalis Fragkos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis

(2015) Young-Sam Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of human DNA polymerases ν and θ expose their end game

(2015) William A Beard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

(2015) Karl E Zahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ

(2015) Christal D. Sohl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Creative template-dependent synthesis by human polymerase mu

(2015) Andrea F. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway

(2015) Joseph A. Newman et al.   STRUCTURE

How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis

(2015) Young-Sam Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of human DNA polymerases ν and θ expose their end game

(2015) William A Beard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

(2015) Karl E Zahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Overexpression of POLQ Confers a Poor Prognosis in Early Breast Cancer Patients

(2015)   Oncotarget

Structure–Function Studies of DNA Polymerase λ

(2014) Katarzyna Bebenek et al.   BIOCHEMISTRY

Structure and Mechanism of DNA Polymerase β

(2014) William A. Beard et al.   BIOCHEMISTRY

The Role of Dbf4-Dependent Protein Kinase in DNA Polymerase ζ-Dependent Mutagenesis in Saccharomyces cerevisiae

(2014) Luis N. Brandão et al.   GENETICS

A Role for DNA Polymerase θ in Promoting Replication through Oxidative DNA Lesion, Thymine Glycol, in Human Cells

(2014) Jung-Hoon Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

(2014) Bret D. Freudenthal et al.   NATURE

Sustained active site rigidity during synthesis by human DNA polymerase μ

(2014) Andrea F Moon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for inhibition of DNA replication by aphidicolin

(2014) Andrey G. Baranovskiy et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of Yeast DNA Polymerase ε Catalytic Domain

(2014) Rinku Jain et al.   PLoS One

Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[a]pyrene dG adduct

(2014) Yang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Pol   purified with accessory subunits is active in translesion DNA synthesis and complements Pol   in cisplatin bypass

(2014) Y.-S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ

(2014) Matthew J. Yousefzadeh et al.   PLoS Genetics

The Transcription Factor TFII-I Promotes DNA Translesion Synthesis and Genomic Stability

(2014) Farjana J. Fattah et al.   PLoS Genetics

In Vivo Occupancy of Mitochondrial Single-Stranded DNA Binding Protein Supports the Strand Displacement Mode of DNA Replication

(2014) Javier Miralles Fusté et al.   PLoS Genetics

Structural insights into eukaryotic DNA replication

(2014) Sylvie Doublié et al.   Frontiers in Microbiology

Observing a DNA Polymerase Choose Right from Wrong

(2013) Bret D. Freudenthal et al.   CELL

Structural Comparison of DNA Polymerase Architecture Suggests a Nucleotide Gateway to the Polymerase Active Site

(2013) Sangwook Wu et al.   CHEMICAL REVIEWS

A Substitution in the Fingers Domain of DNA Polymerase δ Reduces Fidelity by Altering Nucleotide Discrimination in the Catalytic Site

(2013) Marc J. Prindle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism

(2013) Jérôme Gouge et al.   JOURNAL OF MOLECULAR BIOLOGY

Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction

(2013) Vinod K. Batra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ

(2013) Matthew Hogg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of somatic hypermutation at the WA motif by human DNA polymerase  

(2013) Y. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replicative DNA Polymerases

(2013) E. Johansson et al.   Cold Spring Harbor Perspectives in Biology

Clinical and Molecular Features of POLG-Related Mitochondrial Disease

(2013) J. D. Stumpf et al.   Cold Spring Harbor Perspectives in Biology

The Architecture of Yeast DNA Polymerase ζ

(2013) Yacob Gómez-Llorente et al.   Cell Reports

Mechanism for priming DNA synthesis by yeast DNA Polymerase α

(2013) Rajika L Perera et al.   eLife

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Structure of human DNA polymerase iota and the mechanism of DNA synthesis

(2012) A. V. Makarova et al.   BIOCHEMISTRY-MOSCOW

Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage

(2012) Jennifer Chea et al.   CELL CYCLE

DNA polymerase delta in dna replication and genome maintenance

(2012) Marc J. Prindle et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Structural Basis of Recruitment of DNA Polymerase ζ by Interaction between REV1 and REV7 Proteins

(2012) Sotaro Kikuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Rev1-mediated Assembly of a Quaternary Vertebrate Translesion Polymerase Complex Consisting of Rev1, Heterodimeric Polymerase (Pol) ζ, and Pol κ

(2012) Jessica Wojtaszek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Watching DNA polymerase η make a phosphodiester bond

(2012) Teruya Nakamura et al.   NATURE

DNA-binding determinants promoting NHEJ by human Polµ

(2012) Maria Jose Martin et al.   NUCLEIC ACIDS RESEARCH

Ribonucleotides and manganese ions improve non-homologous end joining by human Polµ

(2012) Maria Jose Martin et al.   NUCLEIC ACIDS RESEARCH

A four-subunit DNA polymerase ζ complex containing Pol δ accessory subunits is essential for PCNA-mediated mutagenesis

(2012) Alena V. Makarova et al.   NUCLEIC ACIDS RESEARCH

Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly

(2012) Bret D. Freudenthal et al.   STRUCTURE

Kinetic Analysis of the Unique Error Signature of Human DNA Polymerase ν

(2011) Mercedes E. Arana et al.   BIOCHEMISTRY

DNA polymerases: Mechanistic insight from biochemical and biophysical studies

(2011) Emmanuelle Delagoutte   Frontiers in Bioscience-Landmark

Human HEL308 Localizes to Damaged Replication Forks and Unwinds Lagging Strand Structures

(2011) Agnieszka A. Tafel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Promiscuous DNA synthesis by human DNA polymerase θ

(2011) Matthew Hogg et al.   NUCLEIC ACIDS RESEARCH

Flexible tethering of primase and DNA Pol α in the eukaryotic primosome

(2011) Rafael Núñez-Ramírez et al.   NUCLEIC ACIDS RESEARCH

The Major Roles of DNA Polymerases Epsilon and Delta at the Eukaryotic Replication Fork Are Evolutionarily Conserved

(2011) Izumi Miyabe et al.   PLoS Genetics

Novel Enzymatic Function of DNA Polymerase ν in Translesion DNA Synthesis Past Major Groove DNA−Peptide and DNA−DNA Cross-Links

(2010) Kinrin Yamanaka et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Structural Basis for Proficient Incorporation of dTTP OppositeO6-Methylguanine by Human DNA Polymerase ι

(2010) Matthew G. Pence et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Human REV7 in Complex with a Human REV3 Fragment and Structural Implication of the Interaction between DNA Polymerase ζ and REV1

(2010) Kodai Hara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Synthesis across an Abasic Lesion by Yeast Rev1 DNA Polymerase

(2010) Deepak T. Nair et al.   JOURNAL OF MOLECULAR BIOLOGY

Lesion Bypass Activity of DNA Polymerase θ (POLQ) Is an Intrinsic Property of the Pol Domain and Depends on Unique Sequence Inserts

(2010) Matthew Hogg et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis for the suppression of skin cancers by DNA polymerase η

(2010) Timothy D. Silverstein et al.   NATURE

Structure and mechanism of human DNA polymerase η

(2010) Christian Biertümpfel et al.   NATURE

Genome instability due to ribonucleotide incorporation into DNA

(2010) Stephanie A Nick McElhinny et al.   Nature Chemical Biology

Loop 1 modulates the fidelity of DNA polymerase  

(2010) K. Bebenek et al.   NUCLEIC ACIDS RESEARCH

The high fidelity and unique error signature of human DNA polymerase  

(2010) D. A. Korona et al.   NUCLEIC ACIDS RESEARCH

DNA Polymerases β and λ Mediate Overlapping and Independent Roles in Base Excision Repair in Mouse Embryonic Fibroblasts

(2010) Elena K. Braithwaite et al.   PLoS One

Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase

(2010) S. Vaithiyalingam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential correction of lagging-strand replication errors made by DNA polymerases   and  

(2010) S. A. Nick McElhinny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variations on a theme: Eukaryotic Y-family DNA polymerases

(2009) M. Todd Washington et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Terminal deoxynucleotidyl transferase: The story of a misguided DNA polymerase

(2009) Edward A. Motea et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

DNA polymerase Family X: Function, structure, and cellular roles

(2009) Jennifer Yamtich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

High fidelity and lesion bypass capability of human DNA polymerase δ

(2009) Michael W. Schmitt et al.   BIOCHIMIE

Structural Insight into Processive Human Mitochondrial DNA Synthesis and Disease-Related Polymerase Mutations

(2009) Young-Sam Lee et al.   CELL

Participation of DNA Polymerase   in Replication of Undamaged DNA in Saccharomyces cerevisiae

(2009) M. R. Northam et al.   GENETICS

Structure of the Human Rev1–DNA–dNTP Ternary Complex

(2009) Michael K. Swan et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Insights into Yeast DNA Polymerase δ by Small Angle X-ray Scattering

(2009) Rinku Jain et al.   JOURNAL OF MOLECULAR BIOLOGY

Template strand scrunching during DNA gap repair synthesis by human polymerase λ

(2009) Miguel Garcia-Diaz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase δ

(2009) Michael K Swan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Influence of local sequence context on damaged base conformation in human DNA polymerase ι: molecular dynamics studies of nucleotide incorporation opposite a benzo[a]pyrene-derived adenine lesion

(2009) Kerry Donny-Clark et al.   NUCLEIC ACIDS RESEARCH

Human DNA polymerase   possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro

(2009) R. Prasad et al.   NUCLEIC ACIDS RESEARCH

Conformational transitions in DNA polymerase I revealed by single-molecule FRET

(2009) Y. Santoso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair

(2009) F. A. Kadyrov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lack of DNA Polymerase θ (POLQ) Radiosensitizes Bone Marrow Stromal CellsIn Vitroand Increases Reticulocyte Micronuclei after Total-Body Irradiation

(2009) Julie P. Goff et al.   RADIATION RESEARCH

Accommodation of anN-(Deoxyguanosin-8-yl)-2-acetylaminofluorene Adduct in the Active Site of Human DNA Polymerase ι: Hoogsteen or Watson−Crick Base Pairing?†

(2008) Kerry Donny-Clark et al.   BIOCHEMISTRY

Distribution and roles of X-family DNA polymerases in eukaryotes

(2008) Yukinobu Uchiyama et al.   BIOCHIMIE

The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases

(2008) Scott D McCulloch et al.   CELL RESEARCH

A comparison of BRCT domains involved in nonhomologous end-joining: Introducing the solution structure of the BRCT domain of polymerase lambda

(2008) Geoffrey A. Mueller et al.   DNA REPAIR

Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase λ

(2008) Katarzyna Bebenek et al.   EMBO REPORTS

Control of DNA polymerase λ stability by phosphorylation and ubiquitination during the cell cycle

(2008) Ursula Wimmer et al.   EMBO REPORTS

Polymerase Dynamics at the Eukaryotic DNA Replication Fork

(2008) Peter M. J. Burgers   JOURNAL OF BIOLOGICAL CHEMISTRY

Division of Labor at the Eukaryotic Replication Fork

(2008) Stephanie A. Nick McElhinny et al.   MOLECULAR CELL

Low-fidelity DNA synthesis by human DNA polymerase theta

(2008) M. E. Arana et al.   NUCLEIC ACIDS RESEARCH

Hijacked DNA repair proteins and unchained DNA polymerases

(2008) H. Saribasak et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Protein-Template-Directed Synthesis across an Acrolein-Derived DNA Adduct by Yeast Rev1 DNA Polymerase

(2008) Deepak T. Nair et al.   STRUCTURE

Dividing the workload at a eukaryotic replication fork

(2008) Thomas A. Kunkel et al.   TRENDS IN CELL BIOLOGY

MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings

(2008) Mitch McVey et al.   TRENDS IN GENETICS

DNA polymerase θ (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproduct

(2007) Mineaki Seki et al.   DNA REPAIR