The Effects of Capsaicin on Gastrointestinal Cancers

Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers

(2020) Amy M. Buckley et al.   Nature Reviews Gastroenterology & Hepatology

Capsaicin lacks tumor-promoting effects during colon carcinogenesis in a rat model induced by 1,2-dimethylhydrazine

(2020) Brunno Felipe Ramos Caetano et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

The role of TRPV1 ion channels in the suppression of gastric cancer development

(2020) Nannan Gao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Colorectal Cancer and Nutrition

(2019) Kannan Thanikachalam et al.   Nutrients

The red pepper’s spicy ingredient capsaicin activates AMPK in HepG2 cells through CaMKKβ

(2019) Alicia Bort et al.   PLoS One

The consumption of chili peppers and the risk of colorectal cancer: a matched case-control study

(2019) Yalan Yang et al.   World Journal of Surgical Oncology

TRPV1 Induced Apoptosis of Colorectal Cancer Cells by Activating Calcineurin-NFAT2-p53 Signaling Pathway

(2019) Nengyi Hou et al.   Biomed Research International

Establishment and Characterization of a New Intrahepatic Cholangiocarcinoma Cell Line Resistant to Gemcitabine

(2019) Chiara Varamo et al.   Cancers

Capsaicin inhibits the migration and invasion via the AMPK/NF-κB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression

(2019) Yong Guo et al.   BIOSCIENCE REPORTS

Capsaicin: Effects on the Pathogenesis of Hepatocellular Carcinoma

(2019) Cristian Scheau et al.   MOLECULES

The evolution of surgical treatment for gastrointestinal cancers

(2019) Yoshihiko Maehara et al.   International Journal of Clinical Oncology

Role of Phytochemicals in Cancer Prevention

(2019) Alok Ranjan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vanillin modifies affective responses to but not burning sensations from ethanol in mixtures

(2019) Jessica M. Gaby et al.   PHYSIOLOGY & BEHAVIOR

The Role of Matrix Metalloproteinases in the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma

(2019) Cristian Scheau et al.   Analytical Cellular Pathology

STAT3: An Emerging Therapeutic Target for Hepatocellular Carcinoma

(2019) Carol Lee et al.   Cancers

Do Mutations Turn p53 into an Oncogene?

(2019) Consuelo Pitolli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Calcium signaling and cell cycle: Progression or death

(2018) Juliette Humeau et al.   CELL CALCIUM

Capsaicin inhibits glycolysis in esophageal squamous cell carcinoma by regulating hexokinase‑2 expression

(2018) Xinli Mao et al.   Molecular Medicine Reports

Gastric cancer: epidemiology, prevention, classification, and treatment

(2018) Robert Sitarz et al.   Cancer Management and Research

Binding Efficacy and Thermogenic Efficiency of Pungent and Nonpungent Analogs of Capsaicin

(2018) Padmamalini Baskaran et al.   MOLECULES

Recurrent activations of transient receptor potential vanilloid‐1 and ‐4 promote cellular proliferation and migration in esophageal squamous cell carcinoma cells

(2018) Rongqi Huang et al.   FEBS Open Bio

Extraction, bioavailability, and bioefficacy of capsaicinoids

(2017) Muwen Lu et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Oxidative stress indicated by elevated expression of Nrf2 and 8-OHdG promotes hepatocellular carcinoma progression

(2017) Chakriwong Ma-on et al.   MEDICAL ONCOLOGY

Reactive Oxygen and Nitrogen Species in Carcinogenesis: Implications of Oxidative Stress on the Progression and Development of Several Cancer Types

(2017) Joanna Kruk et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The SigmaR1 chaperone drives breast and colorectal cancer cell migration by tuning SK3-dependent Ca2+ homeostasis

(2017) M Gueguinou et al.   ONCOGENE

Checkpoint inhibitors in gastrointestinal cancers: Expectations and reality

(2017) Hampig Raphael Kourie et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Capsaicin: Friend or Foe in Skin Cancer and Other Related Malignancies?

(2017) Simona-Roxana Georgescu et al.   Nutrients

Understand spiciness: mechanism of TRPV1 channel activation by capsaicin

(2017) Fan Yang et al.   Protein & Cell

Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition

(2016) Fei Wang et al.   CANCER BIOLOGY & THERAPY

Inhibiting ROS-STAT3-dependent autophagy enhanced capsaicin–induced apoptosis in human hepatocellular carcinoma cells

(2016) Xun Chen et al.   FREE RADICAL RESEARCH

Pathobiology of Helicobacter pylori–Induced Gastric Cancer

(2016) Manuel Amieva et al.   GASTROENTEROLOGY

Cyclin D1, cancer progression, and opportunities in cancer treatment

(2016) Shuo Qie et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases

(2016) Shaherin Basith et al.   MOLECULES

Capsaicin Inhibited Aggressive Phenotypes through Downregulation of Tumor-Associated NADH Oxidase (tNOX) by POU Domain Transcription Factor POU3F2

(2016) Hung Chen et al.   MOLECULES

Role of TRP ion channels in cancer and tumorigenesis

(2016) George Shapovalov et al.   Seminars in Immunopathology

Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner

(2016) Consuelo Amantini et al.   Oncotarget

Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence

(2016) Ritesh Kotecha et al.   Oncotarget

The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer’s Disease and Spinal Cord Injury

(2016) Bing Gong et al.   Frontiers in Molecular Neuroscience

Addressing the challenges of pancreatic cancer: Future directions for improving outcomes

(2015) Manuel Hidalgo et al.   PANCREATOLOGY

Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries

(2015) María José Domper Arnal   WORLD JOURNAL OF GASTROENTEROLOGY

Colorectal cancer

(2015) Ernst J. Kuipers et al.   Nature Reviews Disease Primers

Capsaicin Enhances the Drug Sensitivity of Cholangiocarcinoma through the Inhibition of Chemotherapeutic-Induced Autophagy

(2015) Zai-Fa Hong et al.   PLoS One

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health

(2015) William H. Chappell et al.   Oncotarget

EGF promotes mammalian cell growth by suppressing cellular senescence

(2014) Peter B Alexander et al.   CELL RESEARCH

Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK–NF-κB signaling pathway

(2014) Gong-Rak Lee et al.   CLINICAL & EXPERIMENTAL METASTASIS

Capsaicin Mediates Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells via Stabilizing and Activating p53

(2014) Junzhe Jin et al.   International Journal of Biological Sciences

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis

(2014) Petrus R. de Jong et al.   JOURNAL OF CLINICAL INVESTIGATION

Bioavailability of capsaicin and its implications for drug delivery

(2014) William D. Rollyson et al.   JOURNAL OF CONTROLLED RELEASE

Capsaicin Treatment Attenuates Cholangiocarcinoma Carcinogenesis

(2014) Annika Wutka et al.   PLoS One

Expression of Cyclin D1 Is Associated with β-Catenin Expression and Correlates with Good Prognosis in Colorectal Adenocarcinoma

(2014) Kyu Yun Jang et al.   Translational Oncology

Epidemiology of esophageal cancer

(2014) Yuwei Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Association of overexpression of hexokinase II with chemoresistance in epithelial ovarian cancer

(2013) Dong Hoon Suh et al.   CLINICAL AND EXPERIMENTAL MEDICINE

The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces mitochondrial and nuclear DNA damage inCaenorhabditis elegans

(2013) Rakesh Bodhicharla et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Mechanisms and clinical uses of capsaicin

(2013) Surinder Kumar Sharma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Bcl-2 family in inter-organelle modulation of calcium signaling; roles in bioenergetics and cell survival

(2013) Abasha Lewis et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves

(2013) Daisuke Tomohiro et al.   LIFE SCIENCES

Capsaicin induces apoptosis and modulates MAPK signaling in human gastric cancer cells

(2013) SEON-YOUNG PARK et al.   Molecular Medicine Reports

Liver tumor-initiating cells as a therapeutic target for hepatocellular carcinoma

(2012) Terence Kin Wah Lee et al.   CANCER LETTERS

Pancreatic cancer chemoprevention by phytochemicals

(2012) Srinivas Reddy Boreddy et al.   CANCER LETTERS

Vanilloid Receptor-1 Regulates Neurogenic Inflammation in Colon and Protects Mice from Colon Cancer

(2012) A. G. Vinuesa et al.   CANCER RESEARCH

Reactive Intermediates Produced from the Metabolism of the Vanilloid Ring of Capsaicinoids by P450 Enzymes

(2012) Christopher A. Reilly et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS–JNK–CHOP-mediated upregulation of death receptors

(2012) Bokyung Sung et al.   FREE RADICAL BIOLOGY AND MEDICINE

Capsaicin-Mediated tNOX (ENOX2) Up-regulation Enhances Cell Proliferation and Migration in Vitro and in Vivo

(2012) Nei-Chi Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cyclin D1 G870A Polymorphism Contributes to Colorectal Cancer Susceptibility: Evidence from a Systematic Review of 22 Case-Control Studies

(2012) Yongzhi Yang et al.   PLoS One

A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

(2012) Keith Bley et al.   TOXICOLOGIC PATHOLOGY

Involvement of the phosphoinositide 3-kinase/Akt pathway in apoptosis induced by capsaicin in the human pancreatic cancer cell line PANC-1

(2012) JIAN-HONG ZHANG et al.   Oncology Letters

The Two Faces of Capsaicin

(2011) A. M. Bode et al.   CANCER RESEARCH

Inhibition of chronic pancreatitis and pancreatic intraepithelial neoplasia (PanIN) by capsaicin in LSL-KrasG12D/Pdx1-Cre mice

(2011) H. Bai et al.   CARCINOGENESIS

Management of hepatocellular carcinoma: An update

(2011) Jordi Bruix et al.   HEPATOLOGY

Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells

(2011) Seong-Ho Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Chemical and Pharmacological Aspects of Capsaicin

(2011) Maria Reyes-Escogido et al.   MOLECULES

Determination of Capsaicin and Dihydrocapsaicin in Capsicum Fruit Samples using High Performance Liquid Chromatography

(2011) Zeid Abdullah Al Othman et al.   MOLECULES

Capsaicin sensitizes TRAIL-induced apoptosis through Sp1-mediated DR5 up-regulation: Involvement of Ca2+ influx

(2011) Dong-Oh Moon et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3

(2011) Fang-Ming Gu   WORLD JOURNAL OF GASTROENTEROLOGY

Role of p53 in Cell Death and Human Cancers

(2011) Toshinori Ozaki et al.   Cancers

Cocarcinogenic Effect of Capsaicin Involves Activation of EGFR Signaling but Not TRPV1

(2010) M. K. Hwang et al.   CANCER RESEARCH

Antitumor Activity of Capsaicin on Human Colon Cancer Cells in Vitro and Colo 205 Tumor Xenografts in Vivo

(2010) Hsu-Feng Lu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sorafenib Induces Growth Arrest and Apoptosis of Human Glioblastoma Cells through the Dephosphorylation of Signal Transducers and Activators of Transcription 3

(2010) Fan Yang et al.   MOLECULAR CANCER THERAPEUTICS

Genomic and epigenetic profiles of gastric cancer: Potential diagnostic and therapeutic applications

(2010) Keishi Yamashita et al.   SURGERY TODAY

Lysine 269 is essential for cyclin D1 ubiquitylation by the SCFFbx4/αB-crystallin ligase and subsequent proteasome-dependent degradation

(2009) O Barbash et al.   ONCOGENE

Sorafenib in the treatment of advanced hepatocellular carcinoma

(2009) AliBen Mousa   Saudi Journal of Gastroenterology

In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway

(2008) Ruifen Zhang et al.   APOPTOSIS