Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation

Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia

(2018) Matthew L. Edin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor

(2016) Aili L. Lazaar et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Lipidomic profiling of high-fat diet-induced obesity in mice: Importance of cytochrome P450-derived fatty acid epoxides

(2016) Weicang Wang et al.   Obesity

High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22

(2016) Max Gulhane et al.   Scientific Reports

Prostaglandin E2 Exerts Multiple Regulatory Actions on Human Obese Adipose Tissue Remodeling, Inflammation, Adaptive Thermogenesis and Lipolysis

(2016) Verónica García-Alonso et al.   PLoS One

Soluble epoxide hydrolase inhibition improves coronary endothelial function and prevents the development of cardiac alterations in obese insulin-resistant mice

(2015) Clothilde Roche et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Obesity, Aspirin, and Risk of Colorectal Cancer in Carriers of Hereditary Colorectal Cancer: A Prospective Investigation in the CAPP2 Study

(2015) Mohammad Movahedi et al.   JOURNAL OF CLINICAL ONCOLOGY

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

(2015) Pingping Li et al.   NATURE MEDICINE

Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity

(2014) Weibin Zha et al.   JOURNAL OF LIPID RESEARCH

Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis

(2014) G. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides

(2014) Cristina López-Vicario et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ω-3 Polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer

(2014) Weicang Wang et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Soluble epoxide hydrolase inhibition and peroxisome proliferator activated receptor γ agonist improve vascular function and decrease renal injury in hypertensive obese rats

(2013) John D Imig et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates Diet-induced Endoplasmic Reticulum Stress in Liver and Adipose Tissue

(2013) Ahmed Bettaieb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer

(2013) Guodong Zhang et al.   PROGRESS IN LIPID RESEARCH

Soluble Epoxide Hydrolase Gene Deficiency or Inhibition Attenuates Chronic Active Inflammatory Bowel Disease in IL-10(−/−) Mice

(2012) Wanying Zhang et al.   DIGESTIVE DISEASES AND SCIENCES

Prevalence of Obesity and Trends in Body Mass Index Among US Children and Adolescents, 1999-2010

(2012) Cynthia L. Ogden et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prevalence of Obesity and Trends in the Distribution of Body Mass Index Among US Adults, 1999-2010

(2012) Katherine M. Flegal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo

(2012) Suman Kundu et al.   JOURNAL OF LIPID RESEARCH

Reduction of inflammatory bowel disease-induced tumor development in IL-10 knockout mice with soluble epoxide hydrolase gene deficiency

(2012) Wanying Zhang et al.   MOLECULAR CARCINOGENESIS

Inhibition of Soluble Epoxide Hydrolase Attenuates High-Fat-Diet–Induced Hepatic Steatosis by Reduced Systemic Inflammatory Status in Mice

(2012) Yan Liu et al.   PLoS One

High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

(2012) Kyung-Ah Kim et al.   PLoS One

Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Diet-Induced Metabolic Syndrome in Rats

(2011) Abishek Iyer et al.   Experimental Diabetes Research

Diet-induced obesity elevates colonic TNF-α in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer

(2011) Zhenhua Liu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Biological Mechanisms Linking Obesity and Cancer Risk: New Perspectives

(2010) Darren L. Roberts et al.   Annual Review of Medicine

Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension

(2010) Le-Ning Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids

(2010) Christophe Morisseau et al.   JOURNAL OF LIPID RESEARCH

1-Aryl-3-(1-acylpiperidin-4-yl)urea Inhibitors of Human and Murine Soluble Epoxide Hydrolase: Structure−Activity Relationships, Pharmacokinetics, and Reduction of Inflammatory Pain

(2010) Tristan E. Rose et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inflammatory lipid mediators in adipocyte function and obesity

(2010) Abishek Iyer et al.   Nature Reviews Endocrinology

Inhibition of soluble epoxide hydrolase reduces food intake and increases metabolic rate in obese mice

(2010) J.M. do Carmo et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases

(2009) John D. Imig et al.   NATURE REVIEWS DRUG DISCOVERY

Expression and Regulation of Soluble Epoxide Hydrolase in Adipose Tissue

(2009) Bart M. De Taeye et al.   Obesity