Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase
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Title
Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase
Authors
Keywords
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Journal
Scientific Reports
Volume 7, Issue 1, Pages -
Publisher
Springer Nature
Online
2017-08-18
DOI
10.1038/s41598-017-09795-w
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Note: Only part of the references are listed.- Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents
- (2017) Oliver Werz et al. EXPERT OPINION ON THERAPEUTIC PATENTS
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- (2017) Veronika Temml et al. Scientific Reports
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- (2016) Stefanie Liening et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Time-resolved in situ assembly of the leukotriene-synthetic 5-lipoxygenase/5-lipoxygenase-activating protein complex in blood leukocytes
- (2016) Jana Gerstmeier et al. FASEB JOURNAL
- Discovery of Potent Soluble Epoxide Hydrolase (sEH) Inhibitors by Pharmacophore-Based Virtual Screening
- (2016) Birgit Waltenberger et al. Journal of Chemical Information and Modeling
- Evolution of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Cyclooxygenase (COX) Inhibition and Beyond
- (2016) Praveen Rao et al. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
- Recent advances for FLAP inhibitors
- (2015) Daniel Pettersen et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- An experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesis
- (2014) Jana Gerstmeier et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesisin vitroandin vivoby targeting 5-lipoxygenase-activating protein (FLAP)
- (2014) C Pergola et al. BRITISH JOURNAL OF PHARMACOLOGY
- Elucidation of the molecular mechanism and the efficacyin vivoof a novel 1,4-benzoquinone that inhibits 5-lipoxygenase
- (2014) A M Schaible et al. BRITISH JOURNAL OF PHARMACOLOGY
- Multi-target approach for natural products in inflammation
- (2014) Andreas Koeberle et al. DRUG DISCOVERY TODAY
- Pro-resolving lipid mediators are leads for resolution physiology
- (2014) Charles N. Serhan NATURE
- In vivo sex differences in leukotriene biosynthesis in zymosan-induced peritonitis
- (2014) Antonietta Rossi et al. PHARMACOLOGICAL RESEARCH
- Inhibitors of the Arachidonic Acid Cascade: Interfering with Multiple Pathways
- (2013) Karin Meirer et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Recent Advances in the Search for Novel 5-Lipoxygenase Inhibitors
- (2013) Dieter Steinhilber et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Rationally Designed Multitarget Agents Against Inflammation and Pain
- (2013) S. H. Hwang et al. CURRENT MEDICINAL CHEMISTRY
- Synthesis and Structure–Activity Relationship Studies of Novel Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase
- (2013) Karin Meirer et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2013) Tim Lämmermann et al. NATURE
- Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health
- (2012) Christophe Morisseau et al. Annual Review of Pharmacology and Toxicology
- Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids
- (2012) Christophe Morisseau et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Dynamic eicosanoid responses upon different inhibitor and combination treatments on the arachidonic acid metabolic network
- (2012) Chong He et al. Molecular BioSystems
- Epoxides and Soluble Epoxide Hydrolase in Cardiovascular Physiology
- (2012) John D. Imig PHYSIOLOGICAL REVIEWS
- N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF-mediated activation of endothelial nitric oxide synthase
- (2011) Hsin-Han Hou et al. CARDIOVASCULAR RESEARCH
- Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease
- (2011) Jesper Z. Haeggström et al. CHEMICAL REVIEWS
- Synthesis and Structure−Activity Relationship Studies of Urea-Containing Pyrazoles as Dual Inhibitors of Cyclooxygenase-2 and Soluble Epoxide Hydrolase
- (2011) Sung Hee Hwang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Inhibitors of Soluble Epoxide Hydrolase: A Target with Multiple Potential Therapeutic Indications
- (2011) Hong C. Shen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Inhibition of the Soluble Epoxide Hydrolase Promotes Albuminuria in Mice with Progressive Renal Disease
- (2010) Oliver Jung et al. PLoS One
- Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research
- (2010) Carol Kilkenny et al. PLOS BIOLOGY
- Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model
- (2009) Jun-Yan Liu et al. BIOCHEMICAL PHARMACOLOGY
- Catalysis within the lipid bilayer—structure and mechanism of the MAPEG family of integral membrane proteins
- (2008) D MARTINEZMOLINA et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1
- (2008) A. Koeberle et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets
- (2008) Isabel Matias et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- The nuclear membrane organization of leukotriene synthesis
- (2008) A. K. Mandal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology
- (2008) Hedi Harizi et al. TRENDS IN MOLECULAR MEDICINE
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- (2008) J EVANS et al. TRENDS IN PHARMACOLOGICAL SCIENCES
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