Drug repurposing for opioid use disorders: integration of computational prediction, clinical corroboration, and mechanism of action analyses

Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer’s disease in patients with rheumatoid arthritis and psoriasis

(2020) Mengshi Zhou et al.   PLoS One

Combining phenome-driven drug-target interaction prediction with patients’ electronic health records-based clinical corroboration toward drug discovery

(2020) Mengshi Zhou et al.   BIOINFORMATICS

New directions in the treatment of opioid withdrawal

(2020) A Benjamin Srivastava et al.   LANCET

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

(2020) Theo Vos et al.   LANCET

COVID-19 risk and outcomes in patients with substance use disorders: analyses from electronic health records in the United States

(2020) Quan Qiu Wang et al.   MOLECULAR PSYCHIATRY

Increased risk of COVID ‐19 infection and mortality in people with mental disorders: analysis from electronic health records in the United States

(2020) QuanQiu Wang et al.   World Psychiatry

Analyses of Risk, Racial Disparity, and Outcomes Among US Patients With Cancer and COVID-19 Infection

(2020) QuanQiu Wang et al.   JAMA Oncology

When hematologic malignancies meet COVID-19 in the United States: Infections, death and disparities

(2020) QuanQiu Wang et al.   BLOOD REVIEWS

Context-sensitive network analysis identifies food metabolites associated with Alzheimer’s disease: an exploratory study

(2019) Yang Chen et al.   BMC Medical Genomics

Data-driven multiple-level analysis of gut-microbiome-immune-joint interactions in rheumatoid arthritis

(2019) QuanQiu Wang et al.   BMC GENOMICS

Opioid Addiction, Genetic Susceptibility, and Medical Treatments: A Review

(2019) Shao-Cheng Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Opioid receptors: drivers to addiction?

(2018) Emmanuel Darcq et al.   NATURE REVIEWS NEUROSCIENCE

Bupropion attenuates morphine tolerance and dependence: possible role of glutamate, norepinephrine, inflammation, and oxidative stress

(2018) Mostafa Mahmoud Hamdy et al.   Pharmacological Reports

A systems biology approach to predict and characterize human gut microbial metabolites in colorectal cancer

(2018) QuanQiu Wang et al.   Scientific Reports

A Drug-Side Effect Context-Sensitive Network approach for drug target prediction

(2018) Mengshi Zhou et al.   BIOINFORMATICS

Large-scale mining disease comorbidity relationships from post-market drug adverse events surveillance data

(2018) Chunlei Zheng et al.   BMC BIOINFORMATICS

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Using a novel computational drug-repositioning approach (DrugPredict) to rapidly identify potent drug candidates for cancer treatment

(2017) A B Nagaraj et al.   ONCOGENE

A genomics-based systems approach towards drug repositioning for rheumatoid arthritis

(2016) Rong Xu et al.   BMC GENOMICS

Towards understanding brain-gut-microbiome connections in Alzheimer’s disease

(2016) Rong Xu et al.   BMC Systems Biology

Electronic health records to facilitate clinical research

(2016) Martin R. Cowie et al.   Clinical Research in Cardiology

Missing clinical and behavioral health data in a large electronic health record (EHR) system

(2016) Jeanne M Madden et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Opioid Abuse in Chronic Pain — Misconceptions and Mitigation Strategies

(2016) Nora D. Volkow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neurobiologic Advances from the Brain Disease Model of Addiction

(2016) Nora D. Volkow et al.   NEW ENGLAND JOURNAL OF MEDICINE

A genome-wide systems analysis reveals strong link between colorectal cancer and trimethylamine N-oxide (TMAO), a gut microbial metabolite of dietary meat and fat

(2015) Rong Xu et al.   BMC GENOMICS

A survey of current trends in computational drug repositioning

(2015) Jiao Li et al.   BRIEFINGS IN BIOINFORMATICS

The Brain on Drugs: From Reward to Addiction

(2015) Nora D. Volkow et al.   CELL

PhenoPredict: A disease phenome-wide drug repositioning approach towards schizophrenia drug discovery

(2015) Rong Xu et al.   JOURNAL OF BIOMEDICAL INFORMATICS

STITCH 5: augmenting protein–chemical interaction networks with tissue and affinity data

(2015) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

The SIDER database of drugs and side effects

(2015) Michael Kuhn et al.   NUCLEIC ACIDS RESEARCH

New drugs cost US$2.6 billion to develop

(2014) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Efficacy of extended-release tramadol for treatment of prescription opioid withdrawal: A two-phase randomized controlled trial

(2013) Michelle R. Lofwall et al.   DRUG AND ALCOHOL DEPENDENCE

Electronic health records: new opportunities for clinical research

(2013) P. Coorevits et al.   JOURNAL OF INTERNAL MEDICINE

STRING v9.1: protein-protein interaction networks, with increased coverage and integration

(2012) Andrea Franceschini et al.   NUCLEIC ACIDS RESEARCH

Molecular Mechanisms of Opioid Receptor-dependent Signaling and Behavior

(2011) Ream Al-Hasani et al.   ANESTHESIOLOGY

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

New Medications for Substance Use Disorders: Challenges and Opportunities

(2011) Nora D Volkow et al.   NEUROPSYCHOPHARMACOLOGY

Atomoxetine

(2009) Karly P. Garnock-Jones et al.   PEDIATRIC DRUGS