Mitochondrial DAMPs and altered mitochondrial dynamics in OxLDL burden in atherosclerosis

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

Association of hypoxia and mitochondrial damage associated molecular patterns in the pathogenesis of vein graft failure: a pilot study

(2020) Finosh G Thankam et al.   Translational Research

Rosmarinic acid inhibits oxLDL-induced inflammasome activation under high-glucose conditions through downregulating the p38-FOXO1-TXNIP pathway

(2020) Jean Baptiste Nyandwi et al.   BIOCHEMICAL PHARMACOLOGY

P2Y2R activation by ATP induces oxLDL-mediated inflammasome activation through modulation of mitochondrial damage in human endothelial cells

(2019) Hana Jin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cytochrome c can be released into extracellular space and modulate functions of human astrocytes in a toll-like receptor 4-dependent manner

(2019) Tyler J. Wenzel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Metformin reduced NLRP3 inflammasome activity in Ox-LDL stimulated macrophages through adenosine monophosphate activated protein kinase and protein phosphatase 2A

(2019) Lei Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting Endothelial Barrier Dysfunction Caused by Circulating Bacterial and Mitochondrial N-Formyl Peptides With Deformylase

(2019) Patricia Martinez-Quinones et al.   Frontiers in Immunology

Atherothrombosis and the NLRP3 inflammasome – endogenous mechanisms of inhibition

(2019) Mohan Satish et al.   Translational Research

Anti-phospholipid antibody prevalence and association with subclinical atherosclerosis and atherothrombosis in the general population

(2019) Carlo Selmi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation

(2018) Gonzalo J. Martínez et al.   ATHEROSCLEROSIS

HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway

(2018) Shalini Swaroop et al.   Journal of Neuroinflammation

Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases

(2018) Charles S. Dela Cruz et al.   MITOCHONDRION

Pattern recognition receptors mediate pro-inflammatory effects of extracellular mitochondrial transcription factor A (TFAM)

(2018) Stephanie M. Schindler et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation

(2017) Ivan Zanoni et al.   IMMUNITY

Statins Attenuate Activation of the NLRP3 Inflammasome by Oxidized LDL or TNF α in Vascular Endothelial Cells through a PXR-Dependent Mechanism

(2017) Shaolan Wang et al.   MOLECULAR PHARMACOLOGY

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in acute respiratory distress syndrome

(2017) David A Dorward et al.   THORAX

Biosynthesis of Oxidized Lipid Mediators via Lipoprotein Associated Phospholipase A2 Hydrolysis of Extracellular Cardiolipin Induces Endothelial Toxicity.

(2016) Justin R Buland et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mitochondrial signaling in the vascular endothelium: beyond reactive oxygen species

(2016) Andrew O. Kadlec et al.   BASIC RESEARCH IN CARDIOLOGY

Atorvastatin suppresses NLRP3 inflammasome activation via TLR4/MyD88/NF-κB signaling in PMA-stimulated THP-1 monocytes

(2016) Fanqi Kong et al.   BIOMEDICINE & PHARMACOTHERAPY

Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents AtherosclerosisNovelty and Significance

(2016) Gantsetseg Tumurkhuu et al.   CIRCULATION RESEARCH

Epidemiology of Atherosclerosis and the Potential to Reduce the Global Burden of Atherothrombotic Disease

(2016) William Herrington et al.   CIRCULATION RESEARCH

Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation

(2016) S. Robertson et al.   CLINICAL SCIENCE

Interferon-β promotes macrophage foam cell formation by altering both cholesterol influx and efflux mechanisms

(2016) Marieke C.S. Boshuizen et al.   CYTOKINE

The role of mitochondrial DNA damage in the development of atherosclerosis

(2016) Emma P.K. Yu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expression

(2016) Arif Yurdagul et al.   JOURNAL OF CELL SCIENCE

Mitochondrial N-formyl peptides cause airway contraction and lung neutrophil infiltration via formyl peptide receptor activation

(2016) Camilla Ferreira Wenceslau et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Oxidized Low‐Density Lipoprotein (OxLDL)–Treated Dendritic Cells Promote Activation of T Cells in Human Atherosclerotic Plaque and Blood, Which Is Repressed by Statins: microRNA let‐7c Is Integral to the Effect

(2016) Johan Frostegård et al.   Journal of the American Heart Association

Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-κB and P2X7R Signaling in PMA-Induced Macrophages

(2016) Fanqi Kong et al.   Frontiers in Pharmacology

Cytochrome c as a Potentially Clinical Useful Marker of Mitochondrial and Cellular Damage

(2016) Theodoros Eleftheriadis et al.   Frontiers in Immunology

Mitochondrial N-formyl peptides induce cardiovascular collapse and sepsis-like syndrome

(2015) Camilla Ferreira Wenceslau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases

(2015) Kiichi Nakahira et al.   ANTIOXIDANTS & REDOX SIGNALING

Vitamin D Protects Against Atherosclerosis via Regulation of Cholesterol Efflux and Macrophage Polarization in Hypercholesterolemic SwineSignificance

(2015) Kai Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Danger Signaling in Atherosclerosis

(2015) S. Zimmer et al.   CIRCULATION RESEARCH

Endosymbiosis and Eukaryotic Cell Evolution

(2015) John M. Archibald   CURRENT BIOLOGY

Mitochondrial DNA-LL-37 Complex Promotes Atherosclerosis by Escaping from Autophagic Recognition

(2015) Zhiye Zhang et al.   IMMUNITY

N-Formyl peptides drive mitochondrial damage associated molecular pattern induced neutrophil activation through ERK1/2 and P38 MAP kinase signalling pathways

(2015) Jon Hazeldine et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Interleukin-18-induced atherosclerosis involves CD36 and NF-κB crosstalk in Apo E−/− mice

(2015) Owais Mohammad Bhat et al.   Journal of Cardiology

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity

(2015) Krishnakumar Balasubramanian et al.   Science Signaling

Heat shock protein 60 stimulates the migration of vascular smooth muscle cells via Toll-like receptor 4 and ERK MAPK activation

(2015) Ying Zhao et al.   Scientific Reports

Colchicine Acutely Suppresses Local Cardiac Production of Inflammatory Cytokines in Patients With an Acute Coronary Syndrome

(2015) Gonzalo J. Martínez et al.   Journal of the American Heart Association

Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity

(2015) Krishnakumar Balasubramanian et al.   Science Signaling

Oxidized but not native cardiolipin has pro-inflammatory effects, which are inhibited by Annexin A5

(2014) Min Wan et al.   ATHEROSCLEROSIS

Mitochondrial damage-associated molecular patterns and vascular function

(2014) C. F. Wenceslau et al.   EUROPEAN HEART JOURNAL

P2Y2R activation by nucleotides released from oxLDL-treated endothelial cells (ECs) mediates the interaction between ECs and immune cells through RAGE expression and reactive oxygen species production

(2014) So Young Eun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increased levels of anti-heat-shock protein 60 (anti-Hsp60) indicate endothelial dysfunction, atherosclerosis and cardiovascular diseases in patients with mixed connective tissue disease

(2014) Edit Bodolay et al.   IMMUNOLOGIC RESEARCH

Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia

(2014) Jonathan P. Little et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mitochondrial DNA Damage Can Promote Atherosclerosis Independently of Reactive Oxygen Species Through Effects on Smooth Muscle Cells and Monocytes and Correlates With Higher-Risk Plaques in Humans

(2013) Emma Yu et al.   CIRCULATION

Macrophage Mitochondrial Oxidative Stress Promotes Atherosclerosis and Nuclear Factor-κB–Mediated Inflammation in Macrophages

(2013) Ying Wang et al.   CIRCULATION RESEARCH

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

Damage-associated molecular patterns derived from mitochondria may contribute to the hemodialysis-associated inflammation

(2013) Theodoros Eleftheriadis et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Mitochondrial Transcription Factor A, an Endogenous Danger Signal, Promotes TNFα Release via RAGE- and TLR9-Responsive Plasmacytoid Dendritic Cells

(2013) Mark W. Julian et al.   PLoS One

Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis

(2013) Zufeng Ding et al.   Scientific Reports

LOX-1 in atherosclerosis: biological functions and pharmacological modifiers

(2012) Suowen Xu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial Reactive Oxygen Species and Risk of Atherosclerosis

(2012) Maarten Hulsmans et al.   Current Atherosclerosis Reports

Mitochondrial transcription factor A is a proinflammatory mediator in hemorrhagic shock

(2012) Ping Wang   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Mitochondrial Transcription Factor A Serves as a Danger Signal by Augmenting Plasmacytoid Dendritic Cell Responses to DNA

(2012) M. W. Julian et al.   JOURNAL OF IMMUNOLOGY

Humanin, a Cytoprotective Peptide, Is Expressed in Carotid Artherosclerotic Plaques in Humans

(2012) David G. Zacharias et al.   PLoS One

Cardiolipin Binds to CD1d and Stimulates CD1d-Restricted    T Cells in the Normal Murine Repertoire

(2011) M. Dieude et al.   JOURNAL OF IMMUNOLOGY

The complexity of cardiolipin in health and disease

(2011) Steven M. Claypool et al.   TRENDS IN BIOCHEMICAL SCIENCES

Interferon-α priming promotes lipid uptake and macrophage-derived foam cell formation: A novel link between interferon-α and atherosclerosis in lupus

(2010) Jia Li et al.   ARTHRITIS AND RHEUMATISM

Immunization with a combination of ApoB and HSP60 epitopes significantly reduces early atherosclerotic lesion in Apobtm2SgyLdlrtm1Her/J mice

(2010) Xinjie Lu et al.   ATHEROSCLEROSIS

Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress

(2010) A. R. Bachar et al.   CARDIOVASCULAR RESEARCH

Myeloid Type I Interferon Signaling Promotes Atherosclerosis by Stimulating Macrophage Recruitment to Lesions

(2010) Pieter Goossens et al.   Cell Metabolism

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE

(2010) Qin Zhang et al.   SHOCK

RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice

(2009) L. Sun et al.   CARDIOVASCULAR RESEARCH

Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors

(2009) Elliott D. Crouser et al.   CRITICAL CARE MEDICINE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Anti-Cardiolipin Antibodies and Endothelial Function in Patients With Coronary Artery Disease

(2008) Ibrahim Marai et al.   AMERICAN JOURNAL OF CARDIOLOGY

Role of Phospholipid Scramblase 3 in the Regulation of Tumor Necrosis Factor-α-Induced Apoptosis†

(2008) Jihua Liu et al.   BIOCHEMISTRY