Assessing the role of Porphyromonas gingivalis in periodontitis to determine a causative relationship with Alzheimer’s disease

Porphyromonas gingivalis lipopolysaccharide induces cognitive dysfunction, mediated by neuronal inflammation via activation of the TLR4 signaling pathway in C57BL/6 mice

(2018) Jing Zhang et al.   Journal of Neuroinflammation

Porphyromonas gingivalis, a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice

(2018) Ye Ding et al.   Immunity & Ageing

Importance of heterogeneity in Porhyromonas gingivalis lipopolysaccharide lipid A in tissue specific inflammatory signalling

(2018) Ingar Olsen et al.   Journal of Oral Microbiology

Citrullination as a plausible link to periodontitis, rheumatoid arthritis, atherosclerosis and Alzheimer’s disease

(2018) Ingar Olsen et al.   Journal of Oral Microbiology

The Cysteine Protease Inhibitor, E64d, Reduces Brain Amyloid-β and Improves Memory Deficits in Alzheimer's Disease Animal Models by Inhibiting Cathepsin B, but not BACE1, β-Secretase Activity

(2018) Gregory Hook et al.   JOURNAL OF ALZHEIMERS DISEASE

Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue

(2018) Sophie Poole et al.   JOURNAL OF ALZHEIMERS DISEASE

Active Invasion of Porphyromonas gingivalis and Infection-Induced Complement Activation in ApoE-/- Mice Brains

(2018) Sophie Poole et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

(2018) Vladimir Ilievski et al.   PLoS One

The association between oral hygiene and periodontitis: a systematic review and meta-analysis

(2017) Attawood Lertpimonchai et al.   INTERNATIONAL DENTAL JOURNAL

Cerebral Oxidative Stress and Microvasculature Defects in TNF-α Expressing Transgenic and Porphyromonas gingivalis-Infected ApoE–/– Mice

(2017) Farheen Rokad et al.   JOURNAL OF ALZHEIMERS DISEASE

Can Better Management of Periodontal Disease Delay the Onset and Progression of Alzheimer’s Disease?

(2017) Alice Harding et al.   JOURNAL OF ALZHEIMERS DISEASE

A systematic review and meta-analysis of epidemiologic observational evidence on the effect of periodontitis on diabetes An update of the EFP-AAP review

(2017) Filippo Graziani et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Association between chronic periodontitis and the risk of Alzheimer’s disease: a retrospective, population-based, matched-cohort study

(2017) Chang-Kai Chen et al.   Alzheimers Research & Therapy

Apical periodontitis associates with cardiovascular diseases: a cross-sectional study from Sweden

(2017) Eunice Virtanen et al.   BMC Oral Health

Exploring the Association between Alzheimer’s Disease, Oral Health, Microbial Endocrinology and Nutrition

(2017) Alice Harding et al.   Frontiers in Aging Neuroscience

The Porphyromonas gingivalis/Host Interactome Shows Enrichment in GWASdb Genes Related to Alzheimer's Disease, Diabetes and Cardiovascular Diseases

(2017) Chris J. Carter et al.   Frontiers in Aging Neuroscience

Chronic Porphyromonas gingivalis infection accelerates the occurrence of age-related granules in ApoE–/– mice brains

(2017) Sim K. Singhrao et al.   Journal of Oral Microbiology

Chronic Inflammation and Amyloidogenesis in Alzheimer's Disease -- Role of Spirochetes1

(2017) Judith Miklossy   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice

(2017) Yicong Liu et al.   Scientific Reports

Association between periodontitis and ischemic stroke: a systematic review and meta-analysis

(2016) Yago Leira et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Alcohol consumption and risk of periodontitis: a meta-analysis

(2016) Jiantao Wang et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Risk Indicators for Periodontitis in US Adults: NHANES 2009 to 2012

(2016) Paul I. Eke et al.   JOURNAL OF PERIODONTOLOGY

Are Chronic Periodontitis and Gingivitis Associated with Dementia? A Nationwide, Retrospective, Matched-Cohort Study in Taiwan

(2016) Nian-Sheng Tzeng et al.   NEUROEPIDEMIOLOGY

Modulation of inflammasome activity by Porphyromonas gingivalis in periodontitis and associated systemic diseases

(2016) Ingar Olsen et al.   Journal of Oral Microbiology

Periodontitis and Cognitive Decline in Alzheimer’s Disease

(2016) Mark Ide et al.   PLoS One

Diurnal dynamic behavior of microglia in response to infected bacteria through the UDP-P2Y6 receptor system

(2016) Fumiko Takayama et al.   Scientific Reports

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

(2015) Matthew R Halliday et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 to 2012

(2015) Paul I. Eke et al.   JOURNAL OF PERIODONTOLOGY

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

β-amyloid, microglia, and the inflammasome in Alzheimer’s disease

(2015) Maike Gold et al.   Seminars in Immunopathology

Historic evidence to support a causal relationship between spirochetal infections and Alzheimer’s disease

(2015) Judith Miklossy   Frontiers in Aging Neuroscience

Evaluation of patients with Alzheimer's disease before and after dental treatment

(2014) Thaís de Souza Rolim et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review

(2014) Suzanne M. de la Monte   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Toll-Like Receptor 2 and NLRP3 Cooperate To Recognize a Functional Bacterial Amyloid, Curli

(2014) Glenn J. Rapsinski et al.   INFECTION AND IMMUNITY

Active Invasion of Oral and Aortic Tissues by Porphyromonas gingivalis in Mice Causally Links Periodontitis and Atherosclerosis

(2014) Irina M. Velsko et al.   PLoS One

Age-Associated Remodeling of the Intestinal Epithelial Barrier

(2013) L. Tran et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Blood–brain-barriers in aging and in Alzheimer’s disease

(2013) Fernanda Marques et al.   Molecular Neurodegeneration

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Serum antibodies to periodontal pathogens are a risk factor for Alzheimer’s disease

(2012) Pamela Sparks Stein et al.   Alzheimers & Dementia

Dentition, Dental Health Habits, and Dementia: The Leisure World Cohort Study

(2012) Annlia Paganini-Hill et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Exploring the Parallel Development of Microbial Systems in Neonates with Cystic Fibrosis

(2012) G. B. Rogers et al.   mBio

Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease

(2011) Vivian Hook et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Inflammation as a potential mediator for the association between periodontal disease and Alzheimer’s disease

(2011) Amber Watts et al.   Neuropsychiatric Disease and Treatment

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

(2010) Daniel C Lee et al.   Journal of Neuroinflammation

Genetic cathepsin B deficiency reduces β-amyloid in transgenic mice expressing human wild-type amyloid precursor protein

(2009) Vivian Y.H. Hook et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Porphyromonas gingivalis Outer Membrane Vesicles Enter Human Epithelial Cells via an Endocytic Pathway and Are Sorted to Lysosomal Compartments

(2009) N. Furuta et al.   INFECTION AND IMMUNITY

TNF-α and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

(2009) Angela R. Kamer et al.   JOURNAL OF NEUROIMMUNOLOGY

Periodontitis is associated with cognitive impairment among older adults: analysis of NHANES-III

(2009) J M Noble et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Alternative pathways for production of β-amyloid peptides of Alzheimer's disease

(2008) Vivian Hook et al.   BIOLOGICAL CHEMISTRY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY