Cellular and molecular features of senescence in acute lung injury

Epithelial cell senescence induces pulmonary fibrosis through Nanog-mediated fibroblast activation

(2020) Xiang Chen et al.   Aging-US

Functional heterogeneity in senescence

(2020) Kristina Kirschner et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cell senescence and fibrotic lung diseases

(2020) Rui-Ming Liu et al.   EXPERIMENTAL GERONTOLOGY

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Induction of neutrophil extracellular traps during tissue injury: Involvement of STING and Toll-like receptor 9 pathways

(2019) Li Liu et al.   CELL PROLIFERATION

PI3K/Akt pathway-mediated HO-1 induction regulates mitochondrial quality control and attenuates endotoxin-induced acute lung injury

(2019) Jia Shi et al.   LABORATORY INVESTIGATION

Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients

(2019) Hilary E. Faust et al.   CHEST

Senescent cell turnover slows with age providing an explanation for the Gompertz law

(2019) Omer Karin et al.   Nature Communications

Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis

(2018) David W Waters et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Genetic Ablation of p16(Ink4a) Does Not Protect Against Cellular Senescence in Mouse Models of COPD/Emphysema

(2018) Isaac K Sundar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy

(2018) Marco Malavolta et al.   MEDIATORS OF INFLAMMATION

p53 in Bronchial Club Cells Facilitates Chronic Lung Inflammation by Promoting Senescence

(2018) Adi Sagiv et al.   Cell Reports

Quercetin Enhances Ligand-induced Apoptosis in Senescent IPF Fibroblasts and Reduces Lung Fibrosis In Vivo

(2018) Miriam S Hohmann et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

DNMT and HDAC inhibitors together abrogate endotoxemia mediated macrophage death by STAT3-JMJD3 signaling

(2018) Saheli Samanta et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts

(2018) Michael Schuliga et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Preventing loss of mechanosensation by the nuclear membranes of alveolar cells reduces lung injury in mice during mechanical ventilation

(2018) Inés López-Alonso et al.   Science Translational Medicine

The Role of Pulmonary and Systemic Immunosenescence in Acute Lung Injury

(2018) Christina Brandenberger et al.   Aging and Disease

Protective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of mitochondrial function and dynamics

(2018) Aili Dong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosisex vivo

(2017) Mareike Lehmann et al.   EUROPEAN RESPIRATORY JOURNAL

Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence

(2017) Marieke Aarts et al.   GENES & DEVELOPMENT

Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice

(2017) Jin Pan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Potential contribution of mitochondrial DNA damage associated molecular patterns in transfusion products to the development of acute respiratory distress syndrome after multiple transfusions

(2017) Jon D. Simmons et al.   Journal of Trauma and Acute Care Surgery

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential contribution of mitochondrial DNA damage associated molecular patterns in transfusion products to the development of acute respiratory distress syndrome after multiple transfusions

(2017) Jon D. Simmons et al.   Journal of Trauma and Acute Care Surgery

Clinical trials in acute respiratory distress syndrome: challenges and opportunities

(2017) Michael A Matthay et al.   Lancet Respiratory Medicine

Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli

(2016) L. A. Maciel-Barón et al.   AGE

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Essential Role for Premature Senescence of Myofibroblasts in Myocardial Fibrosis

(2016) Kathleen Meyer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

Cellular senescence controls fibrosis in wound healing

(2016) Joon-Il Jun et al.   Aging-US

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Not All DDRs Are Created Equal: Non-Canonical DNA Damage Responses

(2015) Rebecca C. Burgess et al.   CELL

Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury

(2015) Maor Sauler et al.   FASEB JOURNAL

Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins

(2015) Jennifer C. Harr et al.   JOURNAL OF CELL BIOLOGY

Senescence-Associated Secretory Phenotype and Its Possible Role in Chronic Obstructive Pulmonary Disease

(2014) Manish Kumar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stable Cellular Senescence Is Associated with Persistent DDR Activation

(2014) Marzia Fumagalli et al.   PLoS One

DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin

(2014) M. K. Ayrapetov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of DNA Damage Response Signaling by Condensed Chromatin

(2014) Rebecca C. Burgess et al.   Cell Reports

Inhibition of extracellular HMGB1 attenuates hyperoxia-induced inflammatory acute lung injury

(2014) Maria Entezari et al.   Redox Biology

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling

(2013) Jun Liu et al.   CELLULAR SIGNALLING

Acute lung injury

(2013) D. Parekh et al.   CLINICAL MEDICINE

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

(2013) P. P. Shah et al.   GENES & DEVELOPMENT

Valproic Acid Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice

(2013) Mu-huo Ji et al.   INFLAMMATION

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

(2013) Albert R. Davalos et al.   JOURNAL OF CELL BIOLOGY

Anti-inflammatory effects of clarithromycin in ventilator-induced lung injury

(2013) Laura Amado-Rodríguez et al.   RESPIRATORY RESEARCH

Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema

(2013) Marco Chilosi et al.   Translational Research

Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation

(2012) Aurelia Barascu et al.   EMBO JOURNAL

The acute respiratory distress syndrome

(2012) Michael A. Matthay et al.   JOURNAL OF CLINICAL INVESTIGATION

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

(2012) Mohammad Naimul Islam et al.   NATURE MEDICINE

Association between Variations in Cell Cycle Genes and Idiopathic Pulmonary Fibrosis

(2012) Nicoline M. Korthagen et al.   PLoS One

Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling

(2012) S. Rajagopalan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation

(2011) Vanja Pekovic et al.   AGING CELL

Inflammation and matrix remodeling during repair of ventilator-induced lung injury

(2011) Adrián González-López et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16ink4a

(2011) Martin Kosar et al.   CELL CYCLE

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts

(2011) Hyun Tae Kang et al.   PLoS One

p53 and p16INK4A independent induction of senescence by chromatin-dependent alteration of S-phase progression

(2011) Alexandre Prieur et al.   Nature Communications

PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation

(2010) J-J Lee et al.   CELL DEATH AND DIFFERENTIATION

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Resistance to Bleomycin-Induced Lung Fibrosis in MMP-8 Deficient Mice Is Mediated by Interleukin-10

(2010) Emilio García-Prieto et al.   PLoS One

Impaired nuclear functions lead to increased senescence and inefficient differentiation in human myoblasts with a dominant p.R545C mutation in the LMNA gene

(2009) Sebastian Kandert et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Aging in the context of immunological architecture, function and disease outcomes

(2009) Andrea L. DiCarlo et al.   TRENDS IN IMMUNOLOGY

Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury

(2008) Guillermo M. Albaiceta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

P21 Regulates TGF-β1–Induced Pulmonary Responses via a TNF-α–Signaling Pathway

(2007) Masashi Yamasaki et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY