The Application of Mucoadhesive Chitosan Nanoparticles in Nasal Drug Delivery

Induction of systemic immunity through nasal-associated lymphoid tissue (NALT) of mice intranasally immunized with Brucella abortus malate dehydrogenase-loaded chitosan nanoparticles

(2020) Soojin Shim et al.   PLoS One

Chitosan Nanoparticles: Shedding Light on Immunotoxicity and Hemocompatibility

(2020) Sandra Jesus et al.   Frontiers in Bioengineering and Biotechnology

Induction of Th2 response through TLR2-mediated MyD88-dependent pathway in human microfold cells stimulated with chitosan nanoparticles loaded with Brucella abortus Mdh

(2020) Soojin Shim et al.   MICROBIAL PATHOGENESIS

Induction of Th2-related immune responses and production of systemic IgA in mice intranasally immunized with Brucella abortus malate dehydrogenase loaded chitosan nanoparticles

(2019) Sang Hee Soh et al.   VACCINE

PEGylated and CD47-conjugated nanoellipsoidal artificial antigen-presenting cells minimize phagocytosis and augment anti-tumor T-cell responses

(2019) Shilong Song et al.   International Journal of Nanomedicine

Chitosan nano-structure loaded with recombinant E. coli O157:H7 antigens as a vaccine candidate can effectively increase immunization capacity

(2019) Jaleh Khanifar et al.   Artificial Cells Nanomedicine and Biotechnology

Development of a Gold Nanoparticle Vaccine against Enterohemorrhagic Escherichia coli O157:H7

(2019) Javier I. Sanchez-Villamil et al.   mBio

Elicitation of Th1/Th2 related responses in mice by chitosan nanoparticles loaded with Brucella abortus malate dehydrogenase, outer membrane proteins 10 and 19

(2019) Soojin Shim et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Simultaneous Intramuscular And Intranasal Administration Of Chitosan Nanoparticles–Adjuvanted Chlamydia Vaccine Elicits Elevated Protective Responses In The Lung

(2019) Yumeng Li et al.   International Journal of Nanomedicine

Surface modification of PLGA nanoparticles using chitosan: Effect of molecular weight, concentration, and degree of deacetylation

(2018) Nusaiba K. Al-Nemrawi et al.   ADVANCES IN POLYMER TECHNOLOGY

Natural and synthetic polymer for graphene oxide mediated anticancer drug delivery—A comparative study

(2018) Ananya Deb et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Curdlan sulfate–O-linked quaternized chitosan nanoparticles: potential adjuvants to improve the immunogenicity of exogenous antigens via intranasal vaccination

(2018) Shu Zhang et al.   International Journal of Nanomedicine

Mucosal Immune Response in Nasal-Associated Lymphoid Tissue upon Intranasal Administration by Adjuvants

(2018) Hiromi Takaki et al.   Journal of Innate Immunity

Inactivated infectious bronchitis virus vaccine encapsulated in chitosan nanoparticles induces mucosal immune responses and effective protection against challenge

(2018) Priscila Diniz Lopes et al.   VACCINE

Construction of a ptfA chitosan nanoparticle DNA vaccine against Pasteurella multocida and the immune response in chickens

(2018) Q. Gong et al.   VETERINARY JOURNAL

Parameters influencing the size of chitosan-TPP nano- and microparticles

(2018) Sruthi Sreekumar et al.   Scientific Reports

Chitosan Based Self-Assembled Nanoparticles in Drug Delivery

(2018) Javier Pérez Quiñones et al.   Polymers

Cosmetics and Cosmeceutical Applications of Chitin, Chitosan and Their Derivatives

(2018) Inmaculada Aranaz et al.   Polymers

Antimicrobial Peptides and Nanotechnology, Recent Advances and Challenges

(2018) Lubhandwa S. Biswaro et al.   Frontiers in Microbiology

Mucosal Immunity and Protective Efficacy of Intranasal Inactivated Influenza Vaccine Is Improved by Chitosan Nanoparticle Delivery in Pigs

(2018) Santosh Dhakal et al.   Frontiers in Immunology

Trimethyl Chitosan Nanoparticles Encapsulated Protective Antigen Protects the Mice Against Anthrax

(2018) Anshu Malik et al.   Frontiers in Immunology

Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus

(2018) Reshma J. Nevagi et al.   Acta Biomaterialia

Needle-Free Immunization with Chitosan-Based Systems

(2018) Bijay Singh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Liposomal nanoparticle-based conserved peptide influenza vaccine and monosodium urate crystal adjuvant elicit protective immune response in pigs

(2018) Santosh Dhakal et al.   International Journal of Nanomedicine

Pharmaceutical Potential of a Novel Chitosan Derivative Schiff Base with Special Reference to Antibacterial, Anti-Biofilm, Antioxidant, Anti-Inflammatory, Hemocompatibility and Cytotoxic Activities

(2018) Sameh S. Ali et al.   PHARMACEUTICAL RESEARCH

Characterization of immunogenicity of avian influenza antigens encapsulated in PLGA nanoparticles following mucosal and subcutaneous delivery in chickens

(2018) Tamiru Negash Alkie et al.   PLoS One

Intranasal Delivery of Genistein-Loaded Nanoparticles as a Potential Preventive System against Neurodegenerative Disorders

(2018) Giovanna Rassu et al.   Pharmaceutics

Applications of Cellulose-based Materials in Sustained Drug Delivery Systems

(2018) Bo Sun et al.   CURRENT MEDICINAL CHEMISTRY

NALT M cells are important for immune induction for the common mucosal immune system

(2017) Yasuhiro Date et al.   INTERNATIONAL IMMUNOLOGY

Vaccination with poly(D,L-lactide-co-glycolide) nanoparticles loaded with soluble Leishmania antigens and modified with a TNFα-mimicking peptide or monophosphoryl lipid A confers protection against experimental visceral leishmaniasis

(2017) Maritsa Margaroni et al.   International Journal of Nanomedicine

Oral immunization of mice with Omp31-loaded N-trimethyl chitosan nanoparticles induces high protection against Brucella melitensis infection

(2017) Morteza Abkar et al.   International Journal of Nanomedicine

gp85 protein vaccine adjuvanted with silica nanoparticles against ALV-J in chickens

(2017) Jia Cheng et al.   VACCINE

Highly Immunogenic Trimethyl Chitosan-based Delivery System for Intranasal Lipopeptide Vaccines against Group A Streptococcus

(2017) Nirmal Marasini et al.   Current Drug Delivery

Intranasal Vaccination with Mannosylated Chitosan Formulated DNA Vaccine Enables Robust IgA and Cellular Response Induction in the Lungs of Mice and Improves Protection against Pulmonary Mycobacterial Challenge

(2017) Manli Wu et al.   Frontiers in Cellular and Infection Microbiology

An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery

(2017) Munawar Mohammed et al.   Pharmaceutics

Formation and purification of tailored liposomes for drug delivery using a module-based micro continuous-flow system

(2017) Nikolay Dimov et al.   Scientific Reports

Chitosan-based hydrogel implants enriched with calcium ions intended for peripheral nervous tissue regeneration

(2016) Katarzyna Nawrotek et al.   CARBOHYDRATE POLYMERS

Extended wear therapeutic contact lens fabricated from timolol imprinted carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-poly acrylamide as a onetime medication for glaucoma

(2016) T.S. Anirudhan et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

New nasal nanocomplex self-assembled from charged biomacromolecules: N,N,N-Trimethyl chitosan and dextran sulfate

(2016) Abhijeet D. Kulkarni et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Intranasal Administration of Novel Chitosan Nanoparticle/DNA Complexes Induces Antibody Response to Hepatitis B Surface Antigen in Mice

(2016) F. Lebre et al.   MOLECULAR PHARMACEUTICS

Multilayer engineered nanoliposomes as a novel tool for oral delivery of lipopeptide-based vaccines against group A Streptococcus

(2016) Nirmal Marasini et al.   Nanomedicine

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, andToxoplasma gondiichallenges with a single dose

(2016) Jasdave S. Chahal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intranasal Administration of Chitosan Against Influenza A (H7N9) Virus Infection in a Mouse Model

(2016) Mei Zheng et al.   Scientific Reports

Development and characterization of chitosan/hyaluronan film for transdermal delivery of thiocolchicoside

(2015) Federica Bigucci et al.   CARBOHYDRATE POLYMERS

Development of a novel adjuvanted nasal vaccine: C48/80 associated with chitosan nanoparticles as a path to enhance mucosal immunity

(2015) D. Bento et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Mechanical properties and antibacterial activities of novel nanobiocomposite films of chitosan and starch

(2015) Zahra Shariatinia et al.   FOOD HYDROCOLLOIDS

Vaginal inserts based on chitosan and carboxymethylcellulose complexes for local delivery of chlorhexidine: Preparation, characterization and antimicrobial activity

(2015) Federica Bigucci et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Conjugating influenza a (H1N1) antigen to n-trimethylaminoethylmethacrylate chitosan nanoparticles improves the immunogenicity of the antigen after nasal administration

(2015) Qingfeng Liu et al.   JOURNAL OF MEDICAL VIROLOGY

Comparative study of chitosan- and PEG-coated lipid and PLGA nanoparticles as oral delivery systems for cannabinoids

(2015) Matilde Durán-Lobato et al.   JOURNAL OF NANOPARTICLE RESEARCH

Influence of Molecular Weight and Degree of Deacetylation of Low Molecular Weight Chitosan on the Bioactivity of Oral Insulin Preparations

(2015) Nidal Qinna et al.   Marine Drugs

Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications

(2015) Yueh-Hsia Luo et al.   Biomed Research International

Advances and Challenges of Liposome Assisted Drug Delivery

(2015) Lisa Sercombe et al.   Frontiers in Pharmacology

Intranasal Immunization with DOTAP Cationic Liposomes Combined with DC-Cholesterol Induces Potent Antigen-Specific Mucosal and Systemic Immune Responses in Mice

(2015) Rui Tada et al.   PLoS One

Induction of mucosal immune responses and protection of cattle against direct-contact challenge by intranasal delivery with foot-and-mouth disease virus antigen mediated by nanoparticles

(2014) Li Pan et al.   International Journal of Nanomedicine

Rabbit nasal immunization against influenza by dry-powder form of chitosan nanospheres encapsulated with influenza whole virus and adjuvants

(2014) Solmaz Dehghan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The impact of size on particulate vaccine adjuvants

(2014) Ruchi R Shah et al.   Nanomedicine

Group A Streptococcal vaccine candidate: contribution of epitope to size, antigen presenting cell interaction and immunogenicity

(2014) Mehfuz Zaman et al.   Nanomedicine

The mucosal immune system for vaccine development

(2014) Aayam Lamichhane et al.   VACCINE

A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung

(2014) Vanessa Neuhaus et al.   VACCINE

Chitosan Nanoparticle Encapsulated Hemagglutinin-Split Influenza Virus Mucosal Vaccine

(2013) Chompoonuch Sawaengsak et al.   AAPS PHARMSCITECH

Biodistribution of Different Sized Nanoparticles Assessed by Positron Emission Tomography: A General Strategy for Direct Activation of Metal Oxide Particles

(2013) Carlos Pérez-Campaña et al.   ACS Nano

Involvement of MyD88 in zinc oxide nanoparticle-induced lung inflammation

(2013) Han Chang et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Enhanced protection against pulmonary mycobacterial challenge by chitosan-formulated polyepitope gene vaccine is associated with increased pulmonary secretory IgA and gamma-interferon+T cell responses

(2013) Wenqing Ai et al.   MICROBIOLOGY AND IMMUNOLOGY

A Single-Dose PLGA Encapsulated Protective Antigen Domain 4 Nanoformulation Protects Mice against Bacillus anthracis Spore Challenge

(2013) Manish Manish et al.   PLoS One

Intranasal Immunisation with Recombinant Toxoplasma gondii Actin Partly Protects Mice against Toxoplasmosis

(2013) Li-Tian Yin et al.   PLoS One

Role of toll-like receptors 3, 4 and 7 in cellular uptake and response to titanium dioxide nanoparticles

(2013) Peng Chen et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Quantum dots induced monocyte chemotactic protein-1 expression via MyD88-dependent Toll-like receptor signaling pathways in macrophages

(2013) Chia-Chi Ho et al.   TOXICOLOGY

Secretory IgA: Designed for Anti-Microbial Defense

(2013) Per Brandtzaeg   Frontiers in Immunology

Induction of gut IgA production through T cell-dependent and T cell-independent pathways

(2012) Mats Bemark et al.   Annals of the New York Academy of Sciences

Differential intestinal M-cell gene expression response to gut commensals

(2012) Susan Lapthorne et al.   IMMUNOLOGY

Chitosan nanoparticles: a survey of preparation methods

(2012) Ana Grenha   JOURNAL OF DRUG TARGETING

Effect of ligand density, receptor density, and nanoparticle size on cell targeting

(2012) Drew R. Elias et al.   Nanomedicine-Nanotechnology Biology and Medicine

Intranasal immunisation of mice against Streptococcus equi using positively charged nanoparticulate carrier systems

(2012) L. Figueiredo et al.   VACCINE

The mucosal vaccine quandary: Intranasal vs. sublingual immunization against influenza

(2012) Gabriel Pedersen et al.   Human Vaccines & Immunotherapeutics

Strategies for intranasal delivery of vaccines

(2012) Mehfuz Zaman et al.   Drug Delivery and Translational Research

Mucosal Immune System and M Cell-targeting Strategies for Oral Mucosal Vaccination

(2012) Sae-Hae Kim et al.   Immune Network

Surface Charge Affects Cellular Uptake and Intracellular Trafficking of Chitosan-Based Nanoparticles

(2011) Zhan-Guo Yue et al.   BIOMACROMOLECULES

Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects

(2011) Tianhong Dai et al.   Expert Review of Anti-Infective Therapy

Mucosal immunization: A realistic alternative

(2011) Diana C. Otczyk et al.   Human vaccines & immunotherapeutics

The Airway Antigen Sampling System: Respiratory M Cells as an Alternative Gateway for Inhaled Antigens

(2011) Dong-Young Kim et al.   JOURNAL OF IMMUNOLOGY

Chitosan—A versatile semi-synthetic polymer in biomedical applications

(2011) M. Dash et al.   PROGRESS IN POLYMER SCIENCE

Pharmaceutical and immunological evaluation of mucoadhesive nanoparticles based delivery system(s) administered intranasally

(2011) Sharad Mangal et al.   VACCINE

Mucosal immunization provides better protection than subcutaneous immunization against Pasteurella multocida (B:2) in mice preimmunized with the outer membrane proteins

(2011) Subhash Kharb et al.   VETERINARY RESEARCH COMMUNICATIONS

Adaptive Immune Regulation in the Gut: T Cell–Dependent and T Cell–Independent IgA Synthesis

(2010) Sidonia Fagarasan et al.   Annual Review of Immunology

Intranasal Vaccination with Chitosan-DNA Nanoparticles Expressing Pneumococcal Surface Antigen A Protects Mice against Nasopharyngeal Colonization byStreptococcus pneumoniae

(2010) Jianghong Xu et al.   Clinical and Vaccine Immunology

Caveolae-mediated entry of Salmonella typhimurium in a human M-cell model

(2009) Jae Sung Lim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis

(2009) Sinead C. Corr et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Size-Dependent Endocytosis of Nanoparticles

(2008) Sulin Zhang et al.   ADVANCED MATERIALS

Synthesis, characterization and in vitro biological properties of O-methyl free N,N,N-trimethylated chitosan

(2008) Rolf J. Verheul et al.   BIOMATERIALS

Differentiation and homing of IgA-secreting cells

(2008) J R Mora et al.   Mucosal Immunology

Functional differences between M cells and enterocytes in sampling luminal antigens

(2008) Jennelle M. Kyd et al.   VACCINE