The mucosal vaccine quandary: Intranasal vs. sublingual immunization against influenza

Pathogenesis of Influenza A/H5N1 Virus Infection in Ferrets Differs between Intranasal and Intratracheal Routes of Inoculation

(2011) Rogier Bodewes et al.   AMERICAN JOURNAL OF PATHOLOGY

Sublingual therapeutic immunization with a polyvalent bacterial preparation in patients with recurrent respiratory infections: immunomodulatory effect on antigen-specific memory CD4+ T cells and impact on clinical outcome

(2011) D. Alecsandru et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Effects of Different Adjuvants in the Context of Intramuscular and Intranasal Routes on Humoral and Cellular Immune Responses Induced by Detergent-Split A/H3N2 Influenza Vaccines in Mice

(2011) Mariana Baz et al.   Clinical and Vaccine Immunology

Sublingual vaccination

(2011) Cecil Czerkinsky et al.   Human vaccines & immunotherapeutics

Matrix-M adjuvanted virosomal H5N1 vaccine confers protection against lethal viral challenge in a murine model

(2011) Gabriel Pedersen et al.   Influenza and Other Respiratory Viruses

Subclinical Brain Injury Caused by H5N1 Influenza Virus Infection

(2011) K. Shinya et al.   JOURNAL OF VIROLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Evaluation of the Sublingual Route for Administration of Influenza H5N1 Virosomes in Combination with the Bacterial Second Messenger c-di-GMP

(2011) Gabriel Kristian Pedersen et al.   PLoS One

Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

(2011) A. Seubert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An open label Phase I trial of a live attenuated H6N1 influenza virus vaccine in healthy adults

(2011) Kawsar R. Talaat et al.   VACCINE

Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice

(2011) Abdullah S. Madhun et al.   VACCINE

Sublingual Administration of an Adenovirus Serotype 5 (Ad5)-Based Vaccine Confirms Toll-Like Receptor Agonist Activity in the Oral Cavity and Elicits Improved Mucosal and Systemic Cell-Mediated Responses against HIV Antigens despite Preexisting Ad5 Immunity

(2010) Daniel M. Appledorn et al.   Clinical and Vaccine Immunology

Sublingual Immunization Protects against Helicobacter pylori Infection and Induces T and B Cell Responses in the Stomach

(2010) S. Raghavan et al.   INFECTION AND IMMUNITY

Needle-free influenza vaccination

(2010) Jean-Pierre Amorij et al.   LANCET INFECTIOUS DISEASES

Mucosal adjuvants and long-term memory development with special focus on CTA1-DD and other ADP-ribosylating toxins

(2010) N Lycke et al.   Mucosal Immunology

Enhanced humoral and cellular immune responses after sublingual immunization against human papillomavirus 16 L1 protein with adjuvants

(2010) Hee-Jeong Cho et al.   VACCINE

CAF01 liposomes as a mucosal vaccine adjuvant: In vitro and in vivo investigations

(2009) Dennis Christensen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

CCR7-CCL19/CCL21-Regulated Dendritic Cells Are Responsible for Effectiveness of Sublingual Vaccination

(2009) J.-H. Song et al.   JOURNAL OF IMMUNOLOGY

Sublingual Immunization with Nonreplicating Antigens Induces Antibody-Forming Cells and Cytotoxic T Cells in the Female Genital Tract Mucosa and Protects against Genital Papillomavirus Infection

(2009) N. Cuburu et al.   JOURNAL OF IMMUNOLOGY

Neonatal Sublingual Vaccination with Salmonella Proteins and Adjuvant Cholera Toxin or CpG Oligodeoxynucleotides Induces Mucosal and Systemic Immunity in Mice

(2009) Ching-Feng Huang et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Transient Facial Nerve Paralysis (Bell's Palsy) following Intranasal Delivery of a Genetically Detoxified Mutant of Escherichia coli Heat Labile Toxin

(2009) David J. M. Lewis et al.   PLoS One

Contrasting effects of type I interferon as a mucosal adjuvant for influenza vaccine in mice and humans

(2009) Robert B. Couch et al.   VACCINE

Evaluation of two live attenuated cold-adapted H5N1 influenza virus vaccines in healthy adults

(2009) Ruth A. Karron et al.   VACCINE

Delivery of interferon-β to the monkey nervous system following intranasal administration

(2008) R.G. Thorne et al.   NEUROSCIENCE

Sublingual vaccination with influenza virus protects mice against lethal viral infection

(2008) J.-H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA