Activation of the G Protein–Coupled Estrogen Receptor Prevented the Development of Acute Colitis by Protecting the Crypt Cell

A Direct Effect of Sex Hormones on Epithelial Barrier Function in Inflammatory Bowel Disease Models

(2019) Janine van der Giessen et al.   Cells

Activation of G protein–coupled estrogen receptor protects intestine from ischemia/reperfusion injury in mice by protecting the crypt cell proliferation

(2019) Shiquan Chai et al.   CLINICAL SCIENCE

Sex- and Age-Related Estrogen Signaling Alteration in Inflammatory Bowel Diseases: Modulatory Role of Estrogen Receptors

(2019) Damian Jacenik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

G protein-coupled estrogen receptor mediates anti-inflammatory action in Crohn’s disease

(2019) Damian Jacenik et al.   Scientific Reports

G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis

(2019) Damian Jacenik et al.   WORLD JOURNAL OF GASTROENTEROLOGY

G-Protein-Coupled Estrogen Receptor (GPER)-Specific Agonist G1 Induces ER Stress Leading to Cell Death in MCF-7 Cells

(2019) Diep-Khanh Ho Vo et al.   Biomolecules

C/EBP homologous protein-induced loss of intestinal epithelial stemness contributes to bile duct ligation-induced cholestatic liver injury in mice

(2018) Runping Liu et al.   HEPATOLOGY

Perinatal supplementation of 4-phenylbutyrate and glutamine attenuates endoplasmic reticulum stress and improves colonic epithelial barrier function in rats born with intrauterine growth restriction

(2018) Axel Désir-Vigné et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Estrogen receptor α contributes to T cell–mediated autoimmune inflammation by promoting T cell activation and proliferation

(2018) Imran Mohammad et al.   Science Signaling

YAP triggers the Wnt/β-catenin signalling pathway and promotes enterocyte self-renewal, regeneration and tumorigenesis after DSS-induced injury

(2018) Feihong Deng et al.   Cell Death & Disease

Estrogen receptor α contributes to T cell–mediated autoimmune inflammation by promoting T cell activation and proliferation

(2018) Imran Mohammad et al.   Science Signaling

Activation of GABAA Receptors in Colon Epithelium Exacerbates Acute Colitis

(2018) Xuelian Ma et al.   Frontiers in Immunology

Elevated ER stress exacerbates dextran sulfate sodium-induced colitis in PRDX4-knockout mice

(2018) Tomohisa Takagi et al.   FREE RADICAL BIOLOGY AND MEDICINE

G protein-coupled receptor 30 (GPR30) expression pattern in inflammatory bowel disease patients suggests its key role in the inflammatory process. A preliminary study

(2017)   Journal of Gastrointestinal and Liver Diseases

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancer

(2017) Qiao Liu et al.   Molecular Cancer

GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress

(2017) Crystal L. Kraft et al.   Oncotarget

Activation of G protein-coupled estrogen receptor 1 (GPER-1) ameliorates blood-brain barrier permeability after global cerebral ischemia in ovariectomized rats

(2016) Dan Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sex Differences in Experimentally Induced Colitis in Mice: a Role for Estrogens

(2015) Janka Bábíčková et al.   INFLAMMATION

G protein-coupled estrogen receptor is involved in modulating colonic motor function via nitric oxide release in C57BL/6 female mice

(2015) Y. Li et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Treatment of IBD: Where We Are and Where We Are Going

(2014) Charles N Bernstein   AMERICAN JOURNAL OF GASTROENTEROLOGY

Role of G protein-coupled estrogen receptor-1, matrix metalloproteinases 2 and 9, and heparin binding epidermal growth factor-like growth factor in estradiol-17β-stimulated bovine satellite cell proliferation

(2014) E. Kamanga-Sollo et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

Estrogen biology: New insights into GPER function and clinical opportunities

(2014) Eric R. Prossnitz et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis

(2013) Liping Su et al.   GASTROENTEROLOGY

Estrogen Alleviates Acetic Acid-Induced Gastric or Colonic Damage via Both ERα- and ERβ-Mediated and Direct Antioxidant Mechanisms in Rats

(2013) Zarife Nigâr Özdemir Kumral et al.   INFLAMMATION

Estrogen reduces endoplasmic reticulum stress to protect against glucotoxicity induced-pancreatic β-cell death

(2013) Suwattanee Kooptiwut et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Anatomical location and redistribution of G protein-coupled estrogen receptor-1 during the estrus cycle in mouse kidney and specific binding to estrogens but not aldosterone

(2013) Shi-Bin Cheng et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

(2013) Nick Barker   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cancer Therapy: Targeting Cell Cycle Regulators

(2012) Martin Johansson et al.   Anti-Cancer Agents in Medicinal Chemistry

G Protein-Coupled Receptor 30 Mediates Estrogen-Induced Proliferation of Primordial Germ Cells Via EGFR/Akt/β-Catenin Signaling Pathway

(2012) Chutian Ge et al.   ENDOCRINOLOGY

Hormone Therapy Increases Risk of Ulcerative Colitis but not Crohn's Disease

(2012) Hamed Khalili et al.   GASTROENTEROLOGY

Estrogen receptor-β protects against colitis-associated neoplasia in mice

(2012) Diana Saleiro et al.   INTERNATIONAL JOURNAL OF CANCER

Novel G Protein-Coupled Oestrogen Receptor GPR30 Shows Changes in mRNA Expression in the Rat Brain over the Oestrous Cycle

(2012) Emma J. Spary et al.   NEUROSIGNALS

Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis

(2012) YOSHIO ARAKI et al.   ONCOLOGY REPORTS

Intestinal secretory cell ER stress and inflammation: Figure 1

(2011) Michael A. McGuckin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

p53 and PUMA Independently Regulate Apoptosis of Intestinal Epithelial Cells in Patients and Mice With Colitis

(2011) Ramanarao Dirisina et al.   GASTROENTEROLOGY

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Involvement of Endoplasmic Reticulum Stress in Inflammatory Bowel Disease: A Different Implication for Colonic and Ileal Disease?

(2011) Sara Bogaert et al.   PLoS One

ER stress and the unfolded protein response in intestinal inflammation

(2010) Michael A. McGuckin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21 and induction of G2 cell-cycle arrest

(2010) Q K Y Chan et al.   CELL DEATH AND DIFFERENTIATION

Endoplasmic reticulum stress: implications for inflammatory bowel disease pathogenesis

(2010) Arthur Kaser et al.   CURRENT OPINION IN GASTROENTEROLOGY

HIV Protease Inhibitors Induce Endoplasmic Reticulum Stress and Disrupt Barrier Integrity in Intestinal Epithelial Cells

(2009) Xudong Wu et al.   GASTROENTEROLOGY

Endoplasmic reticulum stress and intestinal inflammation

(2009) A Kaser et al.   Mucosal Immunology

Hormonal Replacement Therapy After Menopause Is Protective of Disease Activity in Women With Inflammatory Bowel Disease

(2008) Sunanda V. Kane et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY