Combination of metformin and genistein alleviates non-alcoholic fatty liver disease in high-fat diet-fed mice

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD

(2019) Daniel Garcia et al.   Cell Reports

Genistein can ameliorate hepatic inflammatory reaction in nonalcoholic steatohepatitis rats

(2019) Yimin Yin et al.   BIOMEDICINE & PHARMACOTHERAPY

Protective effect of genistein on nonalcoholic fatty liver disease (NAFLD)

(2019) Xin Xin et al.   BIOMEDICINE & PHARMACOTHERAPY

The Natural History of Nonalcoholic Fatty Liver Disease—An Evolving View

(2018) Christina C. Lindenmeyer et al.   Clinics in Liver Disease

Tetrahydrocurcumin ameliorates free fatty acid-induced hepatic steatosis and improves insulin resistance in HepG2 cells

(2018) Jin-Wun Chen et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Metformin improves obesity-associated inflammation by altering macrophages polarization

(2018) Yuanyuan Jing et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

MCU-knockdown attenuates high glucose-induced inflammation through regulating MAPKs/NF-κB pathways and ROS production in HepG2 cells

(2018) Ghodratollah Panahi et al.   PLoS One

Targeting Metabolism, Insulin Resistance, and Diabetes to Treat Nonalcoholic Steatohepatitis

(2018) Brian N. Finck   DIABETES

Genistein Ameliorates Fat Accumulation Through AMPK Activation in Fatty Acid-Induced BRL Cells

(2017) Huijia Zhong et al.   JOURNAL OF FOOD SCIENCE

Non-alcoholic fatty liver disease: A sign of systemic disease

(2017) Isabella Reccia et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The Obesity Epidemic: A Consequence of Reduced Energy Expenditure and the Uncoupling of Energy Intake?

(2017) Timothy Church et al.   Obesity

Tissue resident macrophages: Key players in the pathogenesis of type 2 diabetes and its complications

(2016) Reza Meshkani et al.   CLINICA CHIMICA ACTA

Inflammation in Alcoholic and Nonalcoholic Fatty Liver Disease: Friend or Foe?

(2016) Bin Gao et al.   GASTROENTEROLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Metformin improves hepatic IRS2/PI3K/Akt signaling in insulin-resistant rats of NASH and cirrhosis

(2016) Hong Xu et al.   JOURNAL OF ENDOCRINOLOGY

Altered Interleukin-10 Signaling in Skeletal Muscle Regulates Obesity-Mediated Inflammation and Insulin Resistance

(2016) Sezin Dagdeviren et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction

(2016) Hadi Khodabandehloo et al.   Translational Research

Repurposing metformin: an old drug with new tricks in its binding pockets

(2015) R. Pryor et al.   BIOCHEMICAL JOURNAL

Metformin affects the features of a human hepatocellular cell line (HepG2) by regulating macrophage polarization in a co-culture microenviroment

(2015) Miaojiao Chen et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK)

(2014) Jia Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine 5'-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

(2014) D. Sag et al.   JOURNAL OF IMMUNOLOGY

Metformin Ameliorates Hepatic Steatosis and Inflammation without Altering Adipose Phenotype in Diet-Induced Obesity

(2014) Shih-Lung Woo et al.   PLoS One

Genistein alleviates the development of nonalcoholic steatohepatitis inApoE―/―mice fed a high-fat diet

(2013) Sookyoung Jeon et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Genistein sensitizes hepatic insulin signaling and modulates lipid regulatory genes through p70 ribosomal S6 kinase-1 inhibition in high-fat–high-fructose diet-fed mice

(2013) Elumalai Arunkumar et al.   PHARMACEUTICAL BIOLOGY

Genistein Suppresses LPS-Induced Inflammatory Response through Inhibiting NF-κB following AMP Kinase Activation in RAW 264.7 Macrophages

(2013) Guiyuan Ji et al.   PLoS One

Mechanisms Involved in the Protective Effects of Metformin Against Nonalcoholic Fatty Liver Disease

(2012) V. J. Barbero-Becerra et al.   CURRENT MEDICINAL CHEMISTRY

AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases

(2012) Rai Ajit K. Srivastava et al.   JOURNAL OF LIPID RESEARCH

Metformin Prevents and Reverses Inflammation in a Non-Diabetic Mouse Model of Nonalcoholic Steatohepatitis

(2012) Yuki Kita et al.   PLoS One

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

(2011) X. Stephenne et al.   DIABETOLOGIA

Anti-inflammatory effect of genistein on non-alcoholic steatohepatitis rats induced by high fat diet and its potential mechanisms

(2011) Guiyuan Ji et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

(2011) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Metformin Reduces Body Weight Gain and Improves Glucose Intolerance in High-Fat Diet-Fed C57BL/6J Mice

(2010) Yukari Matsui et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2010) Qing Liu et al.   Lipids in Health and Disease

The Metabolic Syndrome

(2008) Marc-Andre Cornier et al.   ENDOCRINE REVIEWS

AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade

(2007) Hsiang-Ming Wang et al.   BIOCHEMICAL PHARMACOLOGY