NLRP3 inflammasome priming and activation in cholestatic liver injury via the sphingosine 1-phosphate/S1P receptor 2/Gα(12/13)/MAPK signaling pathway

Inflammation: Cause or consequence of chronic cholestatic liver injury

(2020) Benjamin L. Woolbright   FOOD AND CHEMICAL TOXICOLOGY

Pretreatment of exosomes derived from hUCMSCs with TNF-α ameliorates acute liver failure by inhibiting the activation of NLRP3 in macrophage

(2020) Shuqin Zhang et al.   LIFE SCIENCES

The Role of NLRP3 Inflammasome Activation in the Epithelial to Mesenchymal Transition Process During the Fibrosis

(2020) Amani Abraheem Alsadiq Alyaseer et al.   Frontiers in Immunology

NLRP3 inflammasome activation from Kupffer cells is involved in liver fibrosis of Schistosoma japonicum-infected mice via NF-κB

(2019) Wen-Juan Zhang et al.   Parasites & Vectors

Interleukin-1 Receptor Antagonist Modulates Liver Inflammation and Fibrosis in Mice in a Model-Dependent Manner

(2019) Raphael Meier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

(2019) Alberto Mantovani et al.   IMMUNITY

Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury

(2019) Yuting Jin et al.   Cellular & Molecular Immunology

Cholestatic liver injury induced by food additives, dietary supplements and parenteral nutrition

(2019) Vânia Vilas-Boas et al.   ENVIRONMENT INTERNATIONAL

Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases

(2019) Daphne van der Heide et al.   Frontiers in Immunology

Sphingosine-1-phosphate receptors and innate immunity

(2018) Arielle M. Bryan et al.   CELLULAR MICROBIOLOGY

Glycyrrhizin alleviates non-alcoholic steatohepatitis via modulating bile acids and meta-inflammation

(2018) Tingting Yan et al.   DRUG METABOLISM AND DISPOSITION

Sphingosine-1-phosphate receptor 1 mediates elevated IL-6 signaling to promote chronic inflammation and multitissue damage in sickle cell disease

(2018) Shushan Zhao et al.   FASEB JOURNAL

Selective inhibition of the p38α MAPK–MK2 axis inhibits inflammatory cues including inflammasome priming signals

(2018) Chun Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gα 12 overexpression induced by miR-16 dysregulation contributes to liver fibrosis by promoting autophagy in hepatic stellate cells

(2018) Kyu Min Kim et al.   JOURNAL OF HEPATOLOGY

Inflammasome biology, molecular pathology and therapeutic implications

(2018) Fawaz Awad et al.   PHARMACOLOGY & THERAPEUTICS

Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis

(2018) Karim C. El Kasmi et al.   Nature Communications

Sphingosine 1-Phosphate (S1P)/S1P Receptor2/3 Axis Promotes Inflammatory M1 Polarization of Bone Marrow-Derived Monocyte/Macrophage via G(α)i/o/PI3K/JNK Pathway

(2018) Jingjing Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

DHA attenuates hepatic ischemia reperfusion injury by inhibiting pyroptosis and activating PI3K/Akt pathway

(2018) Ziyi Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inflammasome: A Double-Edged Sword in Liver Diseases

(2018) Jingyun Luan et al.   Frontiers in Immunology

Sphingosine 1-phosphate receptor subtype 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization

(2018) Bhakta Prasad Gaire et al.   Journal of Neuroinflammation

Hepatocyte autotaxin expression promotes liver fibrosis and cancer

(2017) Eleanna Kaffe et al.   HEPATOLOGY

S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β

(2017) Benjamin Weichand et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting hepatic macrophages to treat liver diseases

(2017) Frank Tacke   JOURNAL OF HEPATOLOGY

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation

(2017) Nan Song et al.   MOLECULAR CELL

Bile Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Promotes Neuroinflammation during Hepatic Encephalopathy in Mice

(2017) Matthew McMillin et al.   Frontiers in Cellular Neuroscience

Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2016) Herbert Tilg et al.   HEPATOLOGY

Control of inflammatory responses by ceramide, sphingosine 1-phosphate and ceramide 1-phosphate

(2016) Antonio Gomez-Muñoz et al.   PROGRESS IN LIPID RESEARCH

Sources, metabolism, and regulation of circulating sphingosine-1-phosphate

(2015) Monika Książek et al.   JOURNAL OF LIPID RESEARCH

Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice

(2015) Le Yang et al.   Scientific Reports

NLRP3 inflammasome activation is required for fibrosis development in NAFLD

(2014) Alexander Wree et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis

(2013) Le Yang et al.   JOURNAL OF HEPATOLOGY

Inflammasomes in liver diseases

(2012) Gyongyi Szabo et al.   JOURNAL OF HEPATOLOGY

Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease

(2012) Sorina Georgiana Boaru et al.   Journal of Inflammation-London

Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice

(2010) Fei Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility

(2010) Changyong Li et al.   JOURNAL OF HEPATOLOGY

An update on sphingosine-1-phosphate and other sphingolipid mediators

(2010) Henrik Fyrst et al.   Nature Chemical Biology

Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis

(2009) Changyong Li et al.   JOURNAL OF HEPATOLOGY

"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

(2008) K. Takabe et al.   PHARMACOLOGICAL REVIEWS