Bile Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Promotes Neuroinflammation during Hepatic Encephalopathy in Mice

Bile Acid Signaling Is Involved in the Neurological Decline in a Murine Model of Acute Liver Failure

(2016) Matthew McMillin et al.   AMERICAN JOURNAL OF PATHOLOGY

Outcomes in Adults With Acute Liver Failure Between 1998 and 2013

(2016) Adrian Reuben et al.   ANNALS OF INTERNAL MEDICINE

Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition

(2016) Weihua Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fractalkine suppression during hepatic encephalopathy promotes neuroinflammation in mice

(2016) Matthew McMillin et al.   Journal of Neuroinflammation

Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane

(2016) Vicente Hernández-Rabaza et al.   Journal of Neuroinflammation

Hepatic Encephalopathy

(2016) Eelco F.M. Wijdicks   NEW ENGLAND JOURNAL OF MEDICINE

Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy

(2016) Sherry Dadsetan et al.   Frontiers in Molecular Neuroscience

Role of sphingosine-1-phosphate receptor 1 and sphingosine-1-phosphate receptor 2 in hyperglycemia-induced endothelial cell dysfunction

(2015) SHUHUA CHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell–dependent acute allergic responses

(2015) Carole A. Oskeritzian et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TGR5 signaling reduces neuroinflammation during hepatic encephalopathy

(2015) Matthew McMillin et al.   JOURNAL OF NEUROCHEMISTRY

TGFβ1 exacerbates blood–brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5

(2015) Matthew A McMillin et al.   LABORATORY INVESTIGATION

Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke

(2015) Gab Seok Kim et al.   Nature Communications

Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice

(2015) Le Yang et al.   Scientific Reports

Deletion of mouse FXR gene disturbs multiple neurotransmitter systems and alters neurobehavior

(2015) Fei Huang et al.   Frontiers in Behavioral Neuroscience

Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms

(2014) Matthew Quinn et al.   DIGESTIVE AND LIVER DISEASE

Gli1 activation and protection against hepatic encephalopathy is suppressed by circulating transforming growth factor β1 in mice

(2014) Matthew McMillin et al.   JOURNAL OF HEPATOLOGY

Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline

(2014) Matthew McMillin et al.   Journal of Neuroinflammation

The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity

(2014) Anissa Kempf et al.   PLOS BIOLOGY

Role of Bile Acids in Liver Injury and Regeneration following Acetaminophen Overdose

(2013) Bharat Bhushan et al.   AMERICAN JOURNAL OF PATHOLOGY

Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation

(2013) G. Zhang et al.   BLOOD

Lessons from look-back in acute liver failure? A single centre experience of 3300 patients

(2013) William Bernal et al.   JOURNAL OF HEPATOLOGY

Lipopolysaccharide precipitates hepatic encephalopathy and increases blood-brain barrier permeability in mice with acute liver failure

(2013) Anne Chastre et al.   LIVER INTERNATIONAL

Microglial proliferation in the brain of chronic alcoholics with hepatic encephalopathy

(2013) Claude V. Dennis et al.   METABOLIC BRAIN DISEASE

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

(2012) Anna C. Calkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Real-time analysis of microglial activation and motility in hepatic and hyperammonemic encephalopathy

(2012) V. RANGROO THRANE et al.   NEUROSCIENCE

Inflammatory Cascades Driven by Tumor Necrosis Factor-Alpha Play a Major Role in the Progression of Acute Liver Failure and Its Neurological Complications

(2012) Anne Chastre et al.   PLoS One

Bile Acids Induce Inflammatory Genes in Hepatocytes

(2011) Katryn Allen et al.   AMERICAN JOURNAL OF PATHOLOGY

Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism

(2011) Gabriel Frampton et al.   GUT

Microglia activation in hepatic encephalopathy in rats and humans

(2011) Irina Zemtsova et al.   HEPATOLOGY

Hepatic encephalopathy: A central neuroinflammatory disorder?

(2011) Roger F. Butterworth   HEPATOLOGY

Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes

(2011) Elaine Studer et al.   HEPATOLOGY

Inflammation, mitochondria, and the inhibition of adult neurogenesis

(2011) Ludmila A. Voloboueva et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Hyperammonemia Induces Neuroinflammation That Contributes to Cognitive Impairment in Rats With Hepatic Encephalopathy

(2010) Regina Rodrigo et al.   GASTROENTEROLOGY

Direct Evidence for Central Proinflammatory Mechanisms in Rats with Experimental Acute Liver Failure: Protective Effect of Hypothermia

(2009) Wenlei Jiang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Bile acid transporters

(2009) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

Cerebral inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline

(2009) Wenlei Jiang et al.   JOURNAL OF NEUROCHEMISTRY

The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway

(2008) Sharon DeMorrow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY