Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 64, Issue -, Pages 63-70Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2020.03.002
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Funding
- Accelerating Medicines Partnership (AMP) [MSTP T32GM007739, T32AR071302-01, K01AR066063]
- Carson Family Charitable Trust (LTD), Leon Lowenstein Foundation (LTD) [UH2 AR067691, R01AI079178, 2R01 DK099087]
- Lupus Research Alliance (TTL), St. Giles Foundation (TTL)
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The recent advent of single-cell technologies has fast-tracked the discovery of multiple fibroblast subsets in tissues affected by autoimmune disease. In recent years, interest in lymph node fibroblasts that support and regulate immune cells has also grown, leading to an expanding framework of stromal cell subsets with distinct spatial, transcriptional, and functional characteristics. Inflammation can drive tissue fibroblasts to adopt a lymphoid tissue stromal cell phenotype, suggesting that fibroblasts in diseased tissues can have counterparts in lymphoid tissues. Here, we examine fibroblast subsets in tissues affected by autoimmunity in the context of knowledge gained from studies on lymph node fibroblasts, with the ultimate aim to better understand stromal cell heterogeneity in these immunologically reactive tissues.
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