Article
Immunology
Jinfeng Xie, Bingtian Bi, Yunyun Qin, Wenli Dong, Jiahong Zhong, Mengfan Li, Yufang Cheng, Jiangping Xu, Haitao Wang
Summary: Inhibition of phosphodiesterase-4 (PDE4) can reduce depressive symptoms and inflammation in mice, showing potential as antidepressant drugs. The down-regulation of HMGB1/RAGE signaling pathway and suppression of inflammasome may contribute to the antidepressant-like effects of PDE4 inhibitors.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Clinical Neurology
Wei Shi, Shan Zhang, Yujia Lu, Yaning Wang, Jingjie Zhao, Li Li
Summary: The study using a mouse model found that exposure to chronic unpredictable mild stress (CUMS) can induce depression-like behaviors and decrease Th17 cell counts.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Immunology
Chengchao Zuo, Huan Cao, Fang Feng, Guo Li, Yaqi Huang, Liudi Zhu, Zhongya Gu, Yuyan Yang, Jianguo Chen, Yongsheng Jiang, Furong Wang
Summary: This study aimed to investigate whether rTMS could alleviate neuroglia-associated neuro-inflammatory process in mice models of depression. The results showed that rTMS improved depression-like behaviors and modulated microglia activation, astrocyte levels, pro-inflammatory cytokines, and inflammation-related signaling pathways. These findings provide new insights into the mechanism of rTMS in the treatment of depression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Psychiatry
Shanshan Zhang, Juntao Hu, Guixue Liu, Haoran Wu, Meihui Li, Chenye Shi, Qiong Liu, Wensheng Li
Summary: Neuroinflammation is closely related to the pathophysiology of depression. In this experiment, the role of clomipramine, a tricyclic antidepressant, in depressive-like behavior, hippocampal neuroinflammation, and chronic unpredictable mild stress (CMS)-induced hippocampal volume changes was studied. The results suggest that the antidepressant effect of clomipramine may be related to reduced expression of NLRP3 inflammasome and cleaved IL-1 beta.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Behavioral Sciences
Meng -Meng Li, Xi Wang, Xiao-Dong Chen, Hai-Long Yang, Huai-Sha Xu, Ping Zhou, Rong Gao, Ning Zhang, Jun Wang, Lei Jiang, Na Liu
Summary: This study investigated the potential roles of autophagy-lysosome pathway in regulating NLRP3 inflammasome in depression. The results showed that CUMS-induced depressive mice exhibited increased expression of NLRP3 inflammasome and inflammatory responses, as well as accumulation of autophagy-related markers. Disrupting lysosomal function in vitro also increased NLRP3 inflammasome accumulation and pro-inflammatory factors production. These findings suggest that autophagy is related to NLRP3 inflammasome activation, and dysfunctional lysosomes may contribute to depressive behavior.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Lan Yao, Jianhua Lv, Chao Duan, Xiaoya An, Chen Zhang, Dan Li, Changtian Li, Shuyan Liu
Summary: This study demonstrates that Armillaria mellea fermentation liquor (AFL) alleviates insomnia by modulating the serotonergic system and gut microbiota in rats. AFL treatment showed sedative effects, improved antioxidant enzyme levels, and reduced inflammatory markers. AFL also enhanced serotonin content and receptor expression in the hippocampus. In addition, AFL normalized the gut microbiota composition in insomnia rats. This research provides valuable insights for future clinical studies and the potential use of A. mellea in novel food products.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Neurosciences
Jiacen Li, Qingcui Zeng, Wenjie Su, Menglong Song, Min Xie, Lei Mao
Summary: The study revealed that FBXO10 plays a crucial role in the degradation of RAGE protein. By regulating this axis, it can alleviate behavioral despair and cognitive impairment induced by chronic stress, suppress neuroinflammation, and influence the polarization of microglia. These findings provide a new therapeutic strategy for the prevention and treatment of depression.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Immunology
Katherine Picard, Kanchan Bisht, Silvia Poggini, Stefano Garofalo, Maria Teresa Golia, Bernadette Basilico, Fatima Abdallah, Naomi Ciano Albanese, Irmgard Amrein, Nathalie Vernoux, Kaushik Sharma, Chin Wai Hui, Julie C. Savage, Cristina Limatola, Davide Ragozzino, Laura Maggi, Igor Branchi, Marie-Eve Tremblay
Summary: Chronic psychological stress can lead to neuropsychiatric disorders and affect organ functions through stress hormones, including glucocorticoids. Research suggests that the role of glucocorticoid receptors in microglial cells under stress conditions may have an impact on brain neural and immune processes.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Behavioral Sciences
Gulcin Gacar, Semil Selcen Gocmez, Zehra Seda Halbutogullari, Kamil Can Kilic, Aysenur Kaya, Yusufhan Yazir, Tijen Utkan
Summary: This study investigated the effects of resveratrol on vascular function in a rat model of chronic psychological stress and explored its possible mechanisms. The results showed that resveratrol improved depressive-like behavior, ameliorated vascular dysfunction, and reduced stress-induced inflammation. Therefore, resveratrol may be a therapeutic option with vasculoprotective effects in depression induced by chronic stress.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xueli Jin, Yongjia Hu, Ting Lin, Fei Gao, Ziqi Xu, Xiao Hou, Yu Yin, Shidong Kan, Hui Zhu, Daijie Chen
Summary: This study aims to investigate the relieving effects of selenium-enriched Bifidobacterium longum DD98 on chronic unpredictable mild stress (CUMS)-induced irritable bowel syndrome (IBS) in mice. The results suggest that Se-B. longum DD98 significantly relieved the intestinal symptoms of IBS mice and reduced intestinal permeability and inflammation. Furthermore, Se-B. longum DD98 effectively restored the relative abundance of intestinal microbes and regulated the impaired diversity of gut microbiota in IBS mice.
Article
Biochemistry & Molecular Biology
Hye Rin Jeong, Jong Min Kim, Uk Lee, Jin Yong Kang, Seon Kyeong Park, Hyo Lim Lee, Jong Hyun Moon, Min Ji Kim, Min Ji Go, Ho Jin Heo
Summary: This study evaluated the protective effects of ethyl acetate fraction from Cedrela sinensis (EFCS) against behavioral dysfunction and stress response induced by chronic unpredictable mild stress (CUMS) in mice. The results showed that EFCS alleviated depression-like behavior, inhibited mitochondrial dysfunction, regulated stress hormones, and downregulated inflammatory responses and apoptosis proteins in brain tissues.
Article
Food Science & Technology
Danna Wang, Jianbin Wu, Peilin Zhu, Hanqi Xie, Lianxiao Lu, Wanting Bai, Weixi Pan, Renjie Shi, Jin Ye, Bing Xia, Zhenting Zhao, Yutang Wang, Xuebo Liu, Beita Zhao
Summary: Tryptophan can regulate depression-like behavior through modulating gut microbiota and metabolic pathways, improving neuroinflammation and energy metabolism.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Xiangyu Liu, Yumei Han, Shi Zhou, Junsheng Tian, Xuemei Qin, Cui Ji, Weidi Zhao, Anping Chen
Summary: This study analyzed the effects of aerobic exercise on endogenous serum metabolites in response to chronic stress-induced depression. The results showed that aerobic exercise significantly improved depression-like behavior in rats and modulated metabolites related to amino acid and energy metabolism.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Yulin Zhang, Hongxian Wu, Chaozhi Xu, Shanqian Li, Yue Hu, Zongyi Zhang, Guixian Wu, Yuling Liu, Lin Yang, Yue Huang, Wenjun Lu, Lina Hu
Summary: EGCG alleviates depression-like behavior by suppressing NLRP3 inflammasome and mTOR signaling pathway, restoring autophagy levels, reducing apoptosis marker expression.
FOOD SCIENCE & NUTRITION
(2023)
Article
Behavioral Sciences
Jin-Seok Lee, Ji-Yun Kang, Chang-Gue Son
Summary: This study compared isolation stress and unpredictable chronic mild stress as two representative animal models of stress-induced depressive disorder, finding that isolation stress more strongly induced depressive and anxiety features.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Agriculture, Multidisciplinary
Suraphan Panyod, Wei-Kai Wu, Kuan-Hung Lu, Chun-Ting Liu, Yung-Lin Chu, Chi-Tang Ho, Wen-Luan Wendy Hsiao, Yi-Syuan Lai, Wei-Cheng Chen, Yu-En Lin, Shi-Hang Lin, Ming-Shiang Wu, Lee-Yan Sheen
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Medicine, General & Internal
Chieh-Chang Chen, Wei-Kai Wu, Chih-Min Chang, Suraphan Panyod, Tzu-Pin Lu, Jyh-Ming Liou, Yu-Jen Fang, Eric Y. Chuang, Ming-Shiang Wu
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2020)
Article
Plant Sciences
Yu-En Lin, Yi-Chun Chen, Kuan-Hung Lu, Yun-Ju Huang, Suraphan Panyod, Wei-Ting Liu, Shu-Hui Yang, Yun-Sheng Lu, Mei-Hsing Chen, Lee-Yan Sheen
Summary: The study demonstrated the potential antidepressant effects of Cordyceps militaris, which may be due to its regulation of the stress-related ROCK2/PTEN/Akt pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Yun-Ju Huang, Le-Xin Chrystal Choong, Suraphan Panyod, Yu-En Lin, Huai-Syuan Huang, Kuan-Hung Lu, Wei-Kai Wu, Lee-Yan Sheen
Summary: The water extract of Gastrodia elata Blume demonstrates potent antidepressant-like effects by reversing depression-like behaviors caused by subchronic and mild-socialdefeat-stress, regulating monoaminergic neurotransmission, and altering gut microbiota composition and function.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biology
Yu-En Lin, Chin-Hsien Lin, En-Peng Ho, Yi-Ci Ke, Stavroula Petridi, Christopher J. H. Elliott, Lee-Yan Sheen, Cheng-Ting Chien
Summary: The water extracts of Gastrodia elata Blume (GE) show neuroprotective effects in G2019S-induced Parkinson's disease fruit flies and transgenic mice by improving motor abilities and protecting dopaminergic neurons. The mechanism involves the activation of the Nrf2 protein in glial cells, which inhibits degenerative signaling pathways in neurons, ultimately preventing neuronal loss and maintaining coordination.
Article
Biotechnology & Applied Microbiology
Suraphan Panyod, Wei-Kai Wu, Pei-Chen Chen, Kent-Vui Chong, Yu-Tang Yang, Hsiao-Li Chuang, Chieh-Chang Chen, Rou-An Chen, Po-Yu Liu, Ching-Hu Chung, Huai-Syuan Huang, Angela Yu-Chen Lin, Ting-Chin David Shen, Kai-Chien Yang, Tur-Fu Huang, Cheng-Chih Hsu, Chi-Tang Ho, Hsien-Li Kao, Alexander N. Orekhov, Ming-Shiang Wu, Lee-Yan Sheen
Summary: This study validated the benefits of raw garlic juice in reducing cardiovascular disease risk by modulating the gut microbiota and its metabolites, and it was confirmed in both mouse and human subjects.
NPJ BIOFILMS AND MICROBIOMES
(2022)
Article
Integrative & Complementary Medicine
Yu-En Lin, Meng-Hsuan Lin, Yi-Syuan Lai, Kuan-Hung Lu, Huai-Syuan Huang, Fu-Chuo Peng, Shing-Hwa Liu, Lee-Yan Sheen
Summary: Garlic essential oil (GEO) showed no mutagenicity or clastogenic effects in the experiments and demonstrated no adverse reactions in the subacute toxicity test on mice after oral administration for 28 days.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2022)
Article
Microbiology
Rou-An Chen, Wei-Kai Wu, Suraphan Panyod, Po-Yu Liu, Hsiao-Li Chuang, Yi-Hsun Chen, Qiang Lyu, Hsiu-Ching Hsu, Tzu-Lung Lin, Ting-Chin David Shen, Yu-Tang Yang, Hsin-Bai Zou, Huai-Syuan Huang, Yu-En Lin, Chieh-Chang Chen, Chi-Tang Ho, Hsin-Chih Lai, Ming-Shiang Wu, Cheng-Chih Hsu, Lee-Yan Sheen
Summary: This study demonstrates that even with limited exposure in early life, a residual dose of tylosin might cause long-lasting metabolic disturbances by altering the gut microbiota and its metabolites. Our findings reveal that the gut microbiota is susceptible to previously ignored environmental factors.
Review
Biochemistry & Molecular Biology
Ailyn Irvita Ravinther, Hemaniswarri Dewi Dewadas, Shi Ruo Tong, Chai Nien Foo, Yu-En Lin, Cheng-Ting Chien, Yang Mooi Lim
Summary: Parkinson's disease is a common neurodegenerative disease affecting the ageing population, and its prevalence has increased in recent years. Mutations in Leucine-rich-repeat-kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease, and aberrant LRRK2 kinase activity is also associated with idiopathic Parkinson's disease. This review aims to categorize and synthesize current information on LRRK2-linked Parkinson's disease and identify potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Huai-Syuan Huang, Yu-En Lin, Suraphan Panyod, Rou-An Chen, Ying-Cheng Lin, Laura Min Xuan Chai, Cheng-Chih Hsu, Wei-Kai Wu, Kuan-Hung Lu, Yun-Ju Huang, Lee-Yan Sheen
Summary: This study aimed to investigate the effects of Gastrodia elata Blume water extract (WGE) on depressive-like behavior, cognitive impairment, gut microbiome, and metabolite regulation in ApoE-/- mice. The results showed that WGE improved depressive-like behavior and cognitive impairment, as well as regulated the gut microbiome and metabolites. These findings support the potential use of WGE as a functional and complementary medicine for preventing or alleviating depression and cognitive decline in patients with cardiovascular diseases (CVDs).
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Suraphan Panyod, Wei-Kai Wu, Sin-Yi Peng, Yea-Jing Tseng, Ya-Chi Hsieh, Rou-An Chen, Huai-Syuan Huang, Yi-Hsun Chen, Hsiao-Li Chuang, Cheng-Chih Hsu, Ting-Chin David Shen, Kai-Chien Yang, Chi-Tang Ho, Ming-Shiang Wu, Lee-Yan Sheen
Summary: Recently, the role of gut microbiota in diseases, including cardiovascular disease, has gained research attention. Ginger essential oil (GEO) and its bioactive compound citral have shown anti-atherosclerotic effects by improving lipid profile, blood sugar, insulin resistance, and reducing TMAO levels and inflammatory cytokines. They also modulate gut microbiota diversity and composition.
NPJ SCIENCE OF FOOD
(2023)
Article
Biochemistry & Molecular Biology
Yun-Ju Huang, Min-Shiuan Tsai, Suraphan Panyod, Po-Yu Liu, Kuan-Hung Lu, Cheng-Yu Weng, Huai-Syuan Huang, Cheng-Chih Hsu, Lee-Yan Sheen
Summary: This study found that garlic essential oil and its active constituent diallyl disulfide have therapeutic effects on depressive behavior in an unpredictable chronic mild stress model by attenuating neuroinflammation, modulating intestinal barrier function, and influencing gut microbiota.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)