Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly

Microtubule Nucleation Properties of Single Human γTuRCs Explained by Their Cryo-EM Structure

(2020) Tanja Consolati et al.   DEVELOPMENTAL CELL

The centriole protein CEP76 negatively regulates PLK1 activity in the cytoplasm for proper mitotic progression

(2020) Yutaka Takeda et al.   JOURNAL OF CELL SCIENCE

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer

(2020) Zhong Y. Yeow et al.   NATURE

TRIM37 controls cancer-specific vulnerability to PLK4 inhibition

(2020) Franz Meitinger et al.   NATURE

The Cep57-pericentrin module organizes PCM expansion and centriole engagement

(2019) Koki Watanabe et al.   Nature Communications

Multi-omic measurements of heterogeneity in HeLa cells across laboratories

(2019) Yansheng Liu et al.   NATURE BIOTECHNOLOGY

PCNT is critical for the association and conversion of centrioles to centrosomes during mitosis

(2019) Jaeyoun Kim et al.   JOURNAL OF CELL SCIENCE

PCMD-1 Organizes Centrosome Matrix Assembly in C. elegans

(2019) Anna C. Erpf et al.   CURRENT BIOLOGY

HsSAS-6-dependent cartwheel assembly ensures stabilization of centriole intermediates

(2019) Satoko Yoshiba et al.   JOURNAL OF CELL SCIENCE

Differential Requirements for Centrioles in Mitotic Centrosome Growth and Maintenance

(2019) Gabriela Cabral et al.   DEVELOPMENTAL CELL

Evidence that a positive feedback loop drives centrosome maturation in fly embryos

(2019) Ines Alvarez-Rodrigo et al.   eLife

Spindle-Length-Dependent HURP Localization Allows Centrosomes to Control Kinetochore-Fiber Plus-End Dynamics

(2019) Damian Dudka et al.   CURRENT BIOLOGY

Nu MA assemblies organize microtubule asters to establish spindle bipolarity in acentrosomal human cells

(2019) Takumi Chinen et al.   EMBO JOURNAL

Asymmetric Molecular Architecture of the Human γ-Tubulin Ring Complex

(2019) Michal Wieczorek et al.   CELL

Insights into the assembly and activation of the microtubule nucleator γ-TuRC

(2019) Peng Liu et al.   NATURE

Aurora-PLK1 cascades as key signaling modules in the regulation of mitosis

(2018) Vladimir Joukov et al.   Science Signaling

Error-prone meiotic division and subfertility in mice with oocyte-conditional knockdown of pericentrin

(2017) Claudia Baumann et al.   JOURNAL OF CELL SCIENCE

Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2

(2017) Elsa A. Tungadi et al.   JOURNAL OF CELL SCIENCE

Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer

(2017) Marco R. Cosenza et al.   Cell Reports

A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer

(2016) Pavithra L. Chavali et al.   Nature Communications

Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole

(2016) Yuki Tsuchiya et al.   Nature Communications

Rapid Protein Depletion in Human Cells by Auxin-Inducible Degron Tagging with Short Homology Donors

(2016) Toyoaki Natsume et al.   Cell Reports

Eribulin synergizes with Polo-like kinase 1 inhibitors to induce apoptosis in rhabdomyosarcoma

(2015) Angelika Stehle et al.   CANCER LETTERS

Synergistic induction of apoptosis by a polo-like kinase 1 inhibitor and microtubule-interfering drugs in Ewing sarcoma cells

(2015) Lilly Magdalena Weiß et al.   INTERNATIONAL JOURNAL OF CANCER

PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2

(2015) Hiroshi Hanafusa et al.   NATURE CELL BIOLOGY

Integrity of the Pericentriolar Material Is Essential for Maintaining Centriole Association during M Phase

(2015) Mi Young Seo et al.   PLoS One

Reversible centriole depletion with an inhibitor of Polo-like kinase 4

(2015) Y. L. Wong et al.   SCIENCE

PLK1 regulation of PCNT cleavage ensures fidelity of centriole separation during mitotic exit

(2015) Jaeyoun Kim et al.   Nature Communications

A three-step MTOC fragmentation mechanism facilitates bipolar spindle assembly in mouse oocytes

(2015) Dean Clift et al.   Nature Communications

A Unique Set of Centrosome Proteins Requires Pericentrin for Spindle-Pole Localization and Spindle Orientation

(2014) Chun-Ting Chen et al.   CURRENT BIOLOGY

The Cep192-Organized Aurora A-Plk1 Cascade Is Essential for Centrosome Cycle and Bipolar Spindle Assembly

(2014) Vladimir Joukov et al.   MOLECULAR CELL

The dynamics of microtubule minus ends in the human mitotic spindle

(2014) Nicolas Lecland et al.   NATURE CELL BIOLOGY

Pericentriolar material structure and dynamics

(2014) J. B. Woodruff et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Importance of the CEP215-Pericentrin Interaction for Centrosome Maturation during Mitosis

(2014) Seongjae Kim et al.   PLoS One

Cep192 Controls the Balance of Centrosome and Non-Centrosomal Microtubules during Interphase

(2014) Brian P. O’Rourke et al.   PLoS One

A molecular mechanism of mitotic centrosome assembly in Drosophila

(2014) Paul T Conduit et al.   eLife

Loss of centrioles causes chromosomal instability in vertebrate somatic cells

(2013) Joo-Hee Sir et al.   JOURNAL OF CELL BIOLOGY

The where, when and how of microtubule nucleation - one ring to rule them all

(2012) N. Teixido-Travesa et al.   JOURNAL OF CELL SCIENCE

CEP215 is involved in the dynein-dependent accumulation of pericentriolar matrix proteins for spindle pole formation

(2011) Seongju Lee et al.   CELL CYCLE

PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis

(2011) Kwanwoo Lee et al.   JOURNAL OF CELL BIOLOGY

Microtubule nucleation by γ-tubulin complexes

(2011) Justin M. Kollman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Centrioles Regulate Centrosome Size by Controlling the Rate of Cnn Incorporation into the PCM

(2010) Paul T. Conduit et al.   CURRENT BIOLOGY

CDK5RAP2 stimulates microtubule nucleation by the γ-tubulin ring complex

(2010) Yuk-Kwan Choi et al.   JOURNAL OF CELL BIOLOGY

Centrioles, Centrosomes, and Cilia in Health and Disease

(2009) Erich A. Nigg et al.   CELL

Plk1-Dependent Recruitment of γ-Tubulin Complexes to Mitotic Centrosomes Involves Multiple PCM Components

(2009) Laurence Haren et al.   PLoS One

The Mammalian SPD-2 Ortholog Cep192 Regulates Centrosome Biogenesis

(2008) Fei Zhu et al.   CURRENT BIOLOGY