TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye

TRPV4-AQP4 interactions ‘turbocharge’ astroglial sensitivity to small osmotic gradients

(2016) Anthony Iuso et al.   Channels

TRPV4: Molecular Conductor of a Diverse Orchestra

(2016) John P. M. White et al.   PHYSIOLOGICAL REVIEWS

Differential volume regulation and calcium signaling in two ciliary body cell types is subserved by TRPV4 channels

(2016) Andrew O. Jo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV4 links inflammatory signaling and neuroglial swelling

(2015) Daniel A Ryskamp et al.   Channels

TRPV4 activation triggers the release of melatonin from human non-pigmented ciliary epithelial cells

(2015) Hanan Awad Alkozi et al.   EXPERIMENTAL EYE RESEARCH

TRPV4 regulates the integrity of the blood-cerebrospinal fluid barrier and modulates transepithelial protein transport

(2015) Keishi Narita et al.   FASEB JOURNAL

TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Muller Glia

(2015) A. O. Jo et al.   JOURNAL OF NEUROSCIENCE

Biomechanics of Schlemm's canal endothelium and intraocular pressure reduction

(2015) W. Daniel Stamer et al.   PROGRESS IN RETINAL AND EYE RESEARCH

TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice

(2014) Shaik O. Rahaman et al.   JOURNAL OF CLINICAL INVESTIGATION

Swelling and Eicosanoid Metabolites Differentially Gate TRPV4 Channels in Retinal Neurons and Glia

(2014) D. A. Ryskamp et al.   JOURNAL OF NEUROSCIENCE

Intraocular Pressure Homeostasis: Maintaining Balance in a High-Pressure Environment

(2014) Ted S. Acott et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Primary cilia signaling mediates intraocular pressure sensation

(2014) N. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision

(2014) Daniel Ryskamp et al.   Cells

Recreating a human trabecular meshwork outflow system on microfabricated porous structures

(2013) Karen Y. Torrejon et al.   BIOTECHNOLOGY AND BIOENGINEERING

Mechanotransduction Channels of the Trabecular Meshwork

(2013) Vu T. Tran et al.   CURRENT EYE RESEARCH

From Mechanosensitivity to Inflammatory Responses: New Players in the Pathology of Glaucoma

(2013) David Križaj et al.   CURRENT EYE RESEARCH

Primary cilia are specialized calcium signalling organelles

(2013) Markus Delling et al.   NATURE

TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses

(2013) K. M. Dunn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction

(2012) Padmanabhan P. Pattabiraman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Current understanding of conventional outflow dysfunction in glaucoma

(2012) W. Daniel Stamer et al.   CURRENT OPINION IN OPHTHALMOLOGY

The effect of biophysical attributes of the ocular trabecular meshwork associated with glaucoma on the cell response to therapeutic agents

(2011) Clayton T. McKee et al.   BIOMATERIALS

Characterization of transient receptor potential vanilloid channel 4 (TRPV4) in human corneal endothelial cells

(2011) Stefan Mergler et al.   EXPERIMENTAL EYE RESEARCH

Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains

(2011) Wei Huang et al.   EXPERIMENTAL EYE RESEARCH

Novel therapies for glaucoma: a patent review 2007 – 2011

(2011) Fabrizio Carta et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Rho Signaling Regulates Pannexin 1-mediated ATP Release from Airway Epithelia

(2011) Lucia Seminario-Vidal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Polymodal Ion Channel Transient Receptor Potential Vanilloid 4 Modulates Calcium Flux, Spiking Rate, and Apoptosis of Mouse Retinal Ganglion Cells

(2011) D. A. Ryskamp et al.   JOURNAL OF NEUROSCIENCE

The Molecular and Cellular Identity of Peripheral Osmoreceptors

(2011) Stefan G. Lechner et al.   NEURON

The TRPV4 Channel Contributes to Intercellular Junction Formation in Keratinocytes

(2010) Takaaki Sokabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wild-type and Brachyolmia-causing Mutant TRPV4 Channels Respond Directly to Stretch Force

(2010) Stephen Loukin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

(2010) W. Everaerts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes

(2009) Mimi N. Phan et al.   ARTHRITIS AND RHEUMATISM

TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling

(2009) Charles K. Thodeti et al.   CIRCULATION RESEARCH

The trabecular meshwork outflow pathways: Structural and functional aspects

(2009) Ernst R. Tamm   EXPERIMENTAL EYE RESEARCH

Functional interaction of the cation channel transient receptor potential vanilloid 4 (TRPV4) and actin in volume regulation

(2008) Daniel Becker et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The role of the actomyosin system in regulating trabecular fluid outflow

(2008) Baohe Tian et al.   EXPERIMENTAL EYE RESEARCH