Multi-Target Effects of the Cannabinoid CP55940 on Familial Alzheimer’s Disease PSEN1 E280A Cholinergic-Like Neurons: Role of CB1 Receptor

From Cannabis sativa to Cannabidiol: Promising Therapeutic Candidate for the Treatment of Neurodegenerative Diseases

(2020) Tommaso Cassano et al.   Frontiers in Pharmacology

Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer’s disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca2+ dysregulation: Therapeutic implications

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A Perspective on Multi-target Drugs for Alzheimer’s Disease

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Exploring the Role of PSEN Mutations in the Pathogenesis of Alzheimer’s Disease

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Cannabinoids and Cannabinoid Receptors: The Story so Far

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Trafficking and proteolytic processing of amyloid precursor protein and secretases in Alzheimer's disease development: An up-to-date review

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Neuromodulatory action of picomolar extracellular Aβ42 oligomers on pre- and postsynaptic mechanisms underlying synaptic function and memory

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Efficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer’s Disease

(2019) David Schubert et al.   MOLECULAR NEUROBIOLOGY

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

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Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ

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The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

(2018) Harald Hampel et al.   BRAIN

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

Inhibition of mitochondrial permeability transition pore opening contributes to cannabinoid type 1 receptor agonist ACEA-induced neuroprotection

(2018) Lei Ma et al.   NEUROPHARMACOLOGY

What exactly is ‘N’ in cell culture and animal experiments?

(2018) Stanley E. Lazic et al.   PLOS BIOLOGY

Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease

(2018) Yakeel T. Quiroz et al.   JAMA Neurology

Phenotypic Profile of Early-Onset Familial Alzheimer's Disease Caused by Presenilin-1 E280A Mutation

(2018) Diego Sepulveda-Falla et al.   JOURNAL OF ALZHEIMERS DISEASE

Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history

(2018) Sara Anna Bonini et al.   JOURNAL OF ETHNOPHARMACOLOGY

Direct transdifferentiation of human Wharton’s jelly mesenchymal stromal cells into cholinergic-like neurons

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Increased susceptibility to Aβ toxicity in neuronal cultures derived from familial Alzheimer’s disease (PSEN1-A246E) induced pluripotent stem cells

(2017) Enrique Armijo et al.   NEUROSCIENCE LETTERS

Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization

(2017) Rui Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance

(2016) Ming Lei et al.   NEUROBIOLOGY OF DISEASE

Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase

(2016) Linfeng Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presynaptic Calcium Channel Inhibition Underlies CB1 Cannabinoid Receptor-Mediated Suppression of GABA Release

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c-Jun transactivates Puma gene expression to promote osteoarthritis

(2014) HUADING LU et al.   Molecular Medicine Reports

Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease

(2013) Matthew A. Lalli et al.   Alzheimers & Dementia

Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study

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Mitochondrial CB1 receptors regulate neuronal energy metabolism

(2012) Giovanni Bénard et al.   NATURE NEUROSCIENCE

Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro

(2012) Benjamin S. Harvey et al.   NEUROTOXICOLOGY

Protective Effects of the Synthetic Cannabinoids CP55,940 and JWH-015 on Rat Brain Mitochondria upon Paraquat Exposure

(2010) Carlos Velez-Pardo et al.   NEUROCHEMICAL RESEARCH

Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system

(2009) Jian-xin Shen et al.   ACTA PHARMACOLOGICA SINICA

Acetylcholine induces Ca2+ signaling in chicken retinal pigmented epithelial cells during dedifferentiation

(2009) Mariko Sekiguchi-Tonosaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cytoplasmic Ca2+ concentration changes evoked by cholinergic stimulation in primary astrocyte cultures prepared from the rat cochlear nucleus

(2009) Pál Pap et al.   HEARING RESEARCH

Dissociating  -Amyloid from  7 Nicotinic Acetylcholine Receptor by a Novel Therapeutic Agent, S 24795, Normalizes  7 Nicotinic Acetylcholine and NMDA Receptor Function in Alzheimer's Disease Brain

(2009) H.-Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Endogenous cannabinoid anandamide inhibits nicotinic acetylcholine receptor function in mouse thalamic synaptosomes

(2008) Christopher Butt et al.   JOURNAL OF NEUROCHEMISTRY

The cannabinoid CP55,940 prolongs survival and improves locomotor activity in Drosophila melanogaster against paraquat: Implications in Parkinson's disease

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