Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer’s disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca2+ dysregulation: Therapeutic implications

Molecular Modulation of Human α7 Nicotinic Receptor by Amyloid-β Peptides

(2019) Matías Lasala et al.   Frontiers in Cellular Neuroscience

Does intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein trigger early neurotoxicity in Alzheimer’s disease?

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iPSCs-derived nerve-like cells from familial Alzheimer’s disease PSEN 1 E280A reveal increased amyloid-beta levels and loss of the Y chromosome

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Future prospects and challenges for Alzheimer's disease drug development in the era of the NIA-AA Research Framework

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Recent advances in the neurobiology and neuropharmacology of Alzheimer’s disease

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Our Working Point of View of Tau Protein

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The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

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Neural Differentiation of Spheroids Derived from Human Induced Pluripotent Stem Cells–Mesenchymal Stem Cells Coculture

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Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer’s Disease

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What exactly is ‘N’ in cell culture and animal experiments?

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Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease

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Phenotypic Profile of Early-Onset Familial Alzheimer's Disease Caused by Presenilin-1 E280A Mutation

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Evidence of intraneuronal Aβ accumulation preceding tau pathology in the entorhinal cortex

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Justicidin A Reduces β-Amyloid via Inhibiting Endocytosis of β-Amyloid Precursor Protein

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Direct transdifferentiation of human Wharton’s jelly mesenchymal stromal cells into cholinergic-like neurons

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The Role of Hydrogen Peroxide in Redox-Dependent Signaling: Homeostatic and Pathological Responses in Mammalian Cells

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Alzheimer's disease

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Bax, Bak and beyond - mitochondrial performance in apoptosis

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The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis”

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Fast transdifferentiation of human Wharton’s jelly mesenchymal stem cells into neurospheres and nerve-like cells

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Membrane Binding and Pore Formation by a Cytotoxic Fragment of Amyloid β Peptide

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Increased susceptibility to Aβ toxicity in neuronal cultures derived from familial Alzheimer’s disease (PSEN1-A246E) induced pluripotent stem cells

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Plaque formation and the intraneuronal accumulation of β-amyloid in Alzheimer's disease

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Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization

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Construction of engineered corpus cavernosum with primary mesenchymal stem cells in vitro

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Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

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PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

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Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

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A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis

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Neuroprotective Effect of the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson’s Disease

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Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase

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Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations

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A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs

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Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease

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Arctic mutant Aβ40 aggregates on α7 nicotinic acetylcholine receptors and inhibits their functions

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c-Jun transactivates Puma gene expression to promote osteoarthritis

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Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40

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Models of β-amyloid induced Tau-pathology: the long and “folded” road to understand the mechanism

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Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ42 oligomers via a metalloproteinase-dependent mechanism

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Trans-Dominant Negative Effects of Pathogenic PSEN1 Mutations on  -Secretase Activity and A  Production

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Cytotoxicity of Intracellular A 42 Amyloid Oligomers Involves Ca2+ Release from the Endoplasmic Reticulum by Stimulated Production of Inositol Trisphosphate

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Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

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Multisite phosphorylation of c-Jun at threonine 91/93/95 triggers the onset of c-Jun pro-apoptotic activity in cerebellar granule neurons

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Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study

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Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study

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In Vivo Olfactory Model of APP-Induced Neurodegeneration Reveals a Reversible Cell-Autonomous Function

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Pre-dementia clinical stages in presenilin 1 E280A familial early-onset Alzheimer's disease: a retrospective cohort study

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Acetylcholine induces Ca2+ signaling in chicken retinal pigmented epithelial cells during dedifferentiation

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Human Wharton’s jelly cells can be induced to differentiate into growth factor-secreting oligodendrocyte progenitor-like cells

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Cytoplasmic Ca2+ concentration changes evoked by cholinergic stimulation in primary astrocyte cultures prepared from the rat cochlear nucleus

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