Pathological Mechanisms of Bortezomib-Induced Peripheral Neuropathy

Pain-related changes in cutaneous innervation of patients suffering from bortezomib-induced, diabetic or chronic idiopathic axonal polyneuropathy

(2020) Malik Bechakra et al.   BRAIN RESEARCH

Chemotherapy-induced peripheral neuropathy: part 1—current state of knowledge and perspectives for pharmacotherapy

(2020) Kinga Sałat   Pharmacological Reports

Higher proteotoxic stress rather than mitochondrial damage is involved in higher neurotoxicity of bortezomib compared to carfilzomib

(2020) Ayse Tarbin Jannuzzi et al.   Redox Biology

Management of Oxaliplatin-Induced Peripheral Sensory Neuropathy

(2020) Guido Cavaletti et al.   Cancers

Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice

(2020) Kevin M. Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update

(2020) Charles L. Loprinzi et al.   JOURNAL OF CLINICAL ONCOLOGY

The Actions and Mechanisms of P2X7R and p38 MAPK Activation in Mediating Bortezomib-Induced Neuropathic Pain

(2020) Yan Guo et al.   Biomed Research International

Alpha-lipoic acid alters the antitumor effect of bortezomib in melanoma cells in vitro

(2020) Angéla Takács et al.   Scientific Reports

Prokineticin Receptor Inhibition With PC1 Protects Mouse Primary Sensory Neurons From Neurotoxic Effects of Chemotherapeutic Drugs in vitro

(2020) Giorgia Moschetti et al.   Frontiers in Immunology

An overview of ongoing clinical trials assessing pharmacological therapeutic strategies to manage chemotherapy‐induced peripheral neuropathy, based on preclinical studies in rodent models

(2020) Hichem Bouchenaki et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Targeting prokineticin system counteracts hypersensitivity, neuroinflammation, and tissue damage in a mouse model of bortezomib-induced peripheral neuropathy

(2019) Giorgia Moschetti et al.   Journal of Neuroinflammation

Emerging Perspectives on Pain Management by Modulation of TRP Channels and ANO1

(2019) Yasunori Takayama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Serum lipidomics for exploring biomarkers of bortezomib therapy in patients with multiple myeloma

(2019) Keiko Maekawa et al.   CANCER SCIENCE

Sexually dimorphic therapeutic response in bortezomib-induced neuropathic pain reveals altered pain physiology in female rodents

(2019) Katherine Stockstill et al.   PAIN

Inhibition of TRPA1 and IL-6 Signal Alleviates Neuropathic Pain Following Chemotherapeutic Bortezomib

(2019) D. LIU et al.   PHYSIOLOGICAL RESEARCH

Pain Management in Patients with Multiple Myeloma: An Update

(2019) Flaminia Coluzzi et al.   Cancers

TRP Channels as Potential Drug Targets

(2018) Magdalene M. Moran   Annual Review of Pharmacology and Toxicology

Blocking Mammalian Target of Rapamycin (mTOR) Alleviates Neuropathic Pain Induced by Chemotherapeutic Bortezomib

(2018) Zongsheng Duan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Upregulation of NLRP3 via STAT3-dependent histone acetylation contributes to painful neuropathy induced by bortezomib

(2018) Cui-Cui Liu et al.   EXPERIMENTAL NEUROLOGY

Role of metformin in oxaliplatin-induced peripheral neuropathy in patients with stage III colorectal cancer: randomized, controlled study

(2018) Basma Mahrous El-fatatry et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity

(2018) Alix F. Leblanc et al.   JOURNAL OF CLINICAL INVESTIGATION

Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain

(2018) Katherine Stockstill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dimethyl fumarate ameliorates chemotherapy agent-induced neurotoxicity in vitro

(2018) Takehiro Kawashiri et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

High-dose intravenous immunoglobulins reduce nerve macrophage infiltration and the severity of bortezomib-induced peripheral neurotoxicity in rats

(2018) Cristina Meregalli et al.   Journal of Neuroinflammation

Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib

(2018) Kun Chen et al.   Journal of Neuroinflammation

Tamoxifen suppresses paclitaxel-, vincristine-, and bortezomib-induced neuropathy via inhibition of the protein kinase C/extracellular signal-regulated kinase pathway

(2018) Masanobu Tsubaki et al.   TUMOR BIOLOGY

Proteomic approach for understanding milder neurotoxicity of Carfilzomib against Bortezomib

(2018) Betul Karademir et al.   Scientific Reports

Critical role of Cav3.2 T-type calcium channels in the peripheral neuropathy induced by bortezomib, a proteasome-inhibiting chemotherapeutic agent, in mice

(2018) Shiori Tomita et al.   TOXICOLOGY

Bortezomib induces neuropathic pain through protein kinase C-mediated activation of presynaptic NMDA receptors in the spinal cord

(2017) Jing-Dun Xie et al.   NEUROPHARMACOLOGY

Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats

(2017) Marta V. Hamity et al.   PAIN

Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy

(2017) Claudia Wing et al.   Stem Cell Research

Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy

(2017) Peter M LoCoco et al.   eLife

Upregulation of CCL2 via ATF3/c-Jun interaction mediated the Bortezomib-induced peripheral neuropathy

(2016) Cuicui Liu et al.   BRAIN BEHAVIOR AND IMMUNITY

The peptide Phα1β, from spider venom, acts as a TRPA1 channel antagonist with antinociceptive effects in mice

(2016) Raquel Tonello et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neurotoxicity to DRG neurons varies between rodent strains treated with cisplatin and bortezomib

(2016) Jewel L. Podratz et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Inhibition of the neuronal NFκB pathway attenuates bortezomib-induced neuropathy in a mouse model

(2016) Albert Alé et al.   NEUROTOXICOLOGY

Drug Repurposing for the Development of Novel Analgesics

(2016) Marco Sisignano et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS

(2016) Takahito Miyake et al.   Nature Communications

A phosphotyrosine switch regulates organic cation transporters

(2016) Jason A. Sprowl et al.   Nature Communications

The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives

(2015) Romina Nassini et al.   BRITISH JOURNAL OF PHARMACOLOGY

The possible involvement of JNK activation in the spinal dorsal horn in bortezomib-induced allodynia: the role of TNF-α and IL-1β

(2015) Zhen-Yu Li et al.   Journal of Anesthesia

Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor

(2015) Hitomi Higuchi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Behavioral and pharmacological characteristics of bortezomib-induced peripheral neuropathy in rats

(2015) Shota Yamamoto et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Spinal astrocyte gap junction and glutamate transporter expression contributes to a rat model of bortezomib-induced peripheral neuropathy

(2015) C.R. Robinson et al.   NEUROSCIENCE

Toxic Effects of Bortezomib on Primary Sensory Neurons and Schwann Cells of Adult Mice

(2015) Albert Alé et al.   NEUROTOXICITY RESEARCH

Bortezomib-induced peripheral neurotoxicity: an update

(2014) Andreas A. Argyriou et al.   ARCHIVES OF TOXICOLOGY

TNF-α-mediated JNK activation in the dorsal root ganglion neurons contributes to Bortezomib-induced peripheral neuropathy

(2014) Jie Zhang et al.   BRAIN BEHAVIOR AND IMMUNITY

Altered discharges of spinal neurons parallel the behavioral phenotype shown by rats with bortezomib related chemotherapy induced peripheral neuropathy

(2014) Caleb R. Robinson et al.   BRAIN RESEARCH

Evaluation of tubulin polymerization and chronic inhibition of proteasome as citotoxicity mechanisms in bortezomib-induced peripheral neuropathy

(2014) Cristina Meregalli et al.   CELL CYCLE

Treatment with anti-TNF alpha protects against the neuropathy induced by the proteasome inhibitor bortezomib in a mouse model

(2014) Albert Alé et al.   EXPERIMENTAL NEUROLOGY

The Development and Maintenance of Paclitaxel-induced Neuropathic Pain Require Activation of the Sphingosine 1-Phosphate Receptor Subtype 1

(2014) Kali Janes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline

(2014) Dawn L. Hershman et al.   JOURNAL OF CLINICAL ONCOLOGY

Gabapentin Inhibits Bortezomib-Induced Mechanical Allodynia Through Supraspinal Action in Mice

(2014) Ryo Kitamura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain

(2014) Marco Sisignano et al.   Nature Reviews Neurology

Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat

(2014) Carla Ghelardini et al.   NEUROPHARMACOLOGY

Astrocytes, but not microglia, are activated in oxaliplatin and bortezomib-induced peripheral neuropathy in the rat

(2014) C.R. Robinson et al.   NEUROSCIENCE

The Anti-Diabetic Drug Metformin Protects against Chemotherapy-Induced Peripheral Neuropathy in a Mouse Model

(2014) Qi-Liang Mao-Ying et al.   PLoS One

Chemotherapy-induced peripheral neurotoxicity: A critical analysis

(2013) Susanna B. Park et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Novel Therapeutic Strategy to Prevent Chemotherapy-Induced Persistent Sensory Neuropathy By TRPA1 Blockade

(2013) G. Trevisan et al.   CANCER RESEARCH

Bortezomib alters microtubule polymerization and axonal transport in rat dorsal root ganglion neurons

(2013) Nathan P. Staff et al.   NEUROTOXICOLOGY

Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase

(2013) Kali Janes et al.   PAIN

Bortezomib-Induced Painful Peripheral Neuropathy: An Electrophysiological, Behavioral, Morphological and Mechanistic Study in the Mouse

(2013) Valentina A. Carozzi et al.   PLoS One

Oxaliplatin-induced neurotoxicity is dependent on the organic cation transporter OCT2

(2013) J. A. Sprowl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy

(2012) H. Zheng et al.   EXPERIMENTAL NEUROLOGY

Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events

(2011) S. Arastu-Kapur et al.   CLINICAL CANCER RESEARCH

Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study

(2011) Philippe Moreau et al.   LANCET ONCOLOGY

Somatic and autonomic small fiber neuropathy induced by bortezomib therapy: an immunofluorescence study

(2011) Maria Pia Giannoccaro et al.   NEUROLOGICAL SCIENCES

Proteasome inhibitors increase tubulin polymerization and stabilization in tissue culture cells: A possible mechanism contributing to peripheral neuropathy and cellular toxicity following proteasome inhibition

(2010) Marianne S. Poruchynsky et al.   CELL CYCLE

Neurophysiological and neuropathological characterization of new murine models of chemotherapy-induced chronic peripheral neuropathies

(2010) V.A. Carozzi et al.   EXPERIMENTAL NEUROLOGY

Pathological adaptive responses of Schwann cells to endoplasmic reticulum stress in bortezomib-induced peripheral neuropathy

(2010) Yoon Kyung Shin et al.   GLIA

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

(2010) L.-J. Wu et al.   PHARMACOLOGICAL REVIEWS

Bortezomib-induced painful neuropathy in rats: A behavioral, neurophysiological and pathological study in rats

(2009) Cristina Meregalli et al.   EUROPEAN JOURNAL OF PAIN

Characteristics of bortezomib- and thalidomide-induced peripheral neuropathy

(2009) Vinay Chaudhry et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Bortezomib-induced peripheral neuropathy in multiple myeloma: a comprehensive review of the literature

(2008) A. A. Argyriou et al.   BLOOD