Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy

The neuroprotective compound P7C3-A20 promotes neurogenesis and improves cognitive function after ischemic stroke

(2017) Zachary B. Loris et al.   EXPERIMENTAL NEUROLOGY

Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats

(2017) Marta V. Hamity et al.   PAIN

Paclitaxel-induced painful neuropathy is associated with changes in mitochondrial bioenergetics, glycolysis, and an energy deficit in dorsal root ganglia neurons

(2017) Natalie A. Duggett et al.   PAIN

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

(2016) Kathryn F. Mills et al.   Cell Metabolism

Randomized, Placebo-Controlled, Phase II Study of Veliparib in Combination with Carboplatin and Paclitaxel for Advanced/Metastatic Non–Small Cell Lung Cancer

(2016) Suresh S. Ramalingam et al.   CLINICAL CANCER RESEARCH

Neuroprotective Efficacy of an Aminopropyl Carbazole Derivative P7C3-A20 in Ischemic Stroke

(2016) Shu-Na Wang et al.   CNS Neuroscience & Therapeutics

Protective effect of P7C3 on retinal ganglion cells from optic nerve injury

(2016) Hidehiro Oku et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits

(2016) Bing Zhou et al.   JOURNAL OF CELL BIOLOGY

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism

(2016) Josiah Gerdts et al.   NEURON

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

(2016) Samuel A.J. Trammell et al.   Scientific Reports

Overview of neuropathy associated with taxanes for the treatment of metastatic breast cancer

(2015) Edgardo Rivera et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice

(2015) Myeong Jin Yoon et al.   Cell Metabolism

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Physiological and pathophysiological roles of NAMPT and NAD metabolism

(2015) Antje Garten et al.   Nature Reviews Endocrinology

Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury

(2015) S.W.P. Kemp et al.   NEUROSCIENCE

Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ

(2015) Karen Krukowski et al.   PAIN

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

NAD Biosynthesis in Humans - Enzymes, Metabolites and Therapeutic Aspects

(2015) Christian Dölle et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Chemotherapy-induced neuropathy: A comprehensive survey

(2014) N.C. Miltenburg et al.   CANCER TREATMENT REVIEWS

P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

(2014) Gelin Wang et al.   CELL

Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline

(2014) Dawn L. Hershman et al.   JOURNAL OF CLINICAL ONCOLOGY

Mitotoxicity in distal symmetrical sensory peripheral neuropathies

(2014) Gary J. Bennett et al.   Nature Reviews Neurology

P7C3 Neuroprotective Chemicals Block Axonal Degeneration and Preserve Function after Traumatic Brain Injury

(2014) Terry C. Yin et al.   Cell Reports

Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent In Vivo Activity

(2013) A. L. Risinger et al.   CANCER RESEARCH

The High Energy Demand of Neuronal Cells Caused by Passive Leak Currents is Not a Waste of Energy

(2013) Nikolaus Berndt et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Nicotinamide Phosphoribosyltransferase Is Required for the Calorie Restriction-Mediated Improvements in Oxidative Stress, Mitochondrial Biogenesis, and Metabolic Adaptation

(2013) J. Song et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase

(2013) Kali Janes et al.   PAIN

A Novel and Selective Poly (ADP-Ribose) Polymerase Inhibitor Ameliorates Chemotherapy-Induced Painful Neuropathy

(2013) Lauren E. Ta et al.   PLoS One

Impact of Chemotherapy-Induced Peripheral Neuropathy on Treatment Delivery in Nonmetastatic Breast Cancer

(2013) Rebecca M. Speck et al.   Journal of Oncology Practice

Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy

(2012) An Verheyen et al.   BRAIN

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy

(2012) H. Zheng et al.   EXPERIMENTAL NEUROLOGY

PARP inhibitors attenuate chemotherapy-induced painful neuropathy

(2012) Jill-Desiree Brederson et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and prevention

(2012) W. Grisold et al.   NEURO-ONCOLOGY

The interplay of neuronal mitochondrial dynamics and bioenergetics: Implications for Parkinson's disease

(2012) Victor S. Van Laar et al.   NEUROBIOLOGY OF DISEASE

High spontaneous activity of C-nociceptors in painful polyneuropathy

(2012) Inge Petter Kleggetveit et al.   PAIN

A Novel Behavioral Assay for Measuring Cold Sensation in Mice

(2012) Daniel S. Brenner et al.   PLoS One

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis

(2012) R. Tesla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease

(2012) H. De Jesus-Cortes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of Neuropathy-Inducing Effects of Eribulin Mesylate, Paclitaxel, and Ixabepilone in Mice

(2011) K. M. Wozniak et al.   CANCER RESEARCH

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Chemotherapy-induced peripheral neurotoxicity (CIPN): An update

(2011) Andreas A. Argyriou et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Terminal arbor degeneration - a novel lesion produced by the antineoplastic agent paclitaxel

(2011) Gary J. Bennett et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Functional deficits in peripheral nerve mitochondria in rats with paclitaxel- and oxaliplatin-evoked painful peripheral neuropathy

(2011) Huaien Zheng et al.   EXPERIMENTAL NEUROLOGY

Pronociceptive Pain Modulation in Patients with Painful Chemotherapy-Induced Polyneuropathy

(2011) Hadas Nahman-Averbuch et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Mitochondrial abnormality in sensory, but not motor, axons in paclitaxel-evoked painful peripheral neuropathy in the rat

(2011) W.H. Xiao et al.   NEUROSCIENCE

Discovery of a Proneurogenic, Neuroprotective Chemical

(2010) Andrew A. Pieper et al.   CELL

Metadata matters: access to image data in the real world

(2010) Melissa Linkert et al.   JOURNAL OF CELL BIOLOGY

Prevention of Paclitaxel-Induced Allodynia by Minocycline: Effect on Loss of Peripheral Nerve Fibers and Infiltration of Macrophages in Rats

(2010) Cui-Cui Liu et al.   Molecular Pain

Chemotherapy-induced peripheral neurotoxicity

(2010) Guido Cavaletti et al.   Nature Reviews Neurology

Natural history of cutaneous innervation following herpes zoster

(2010) Karin Lottrup Petersen et al.   PAIN

Structure and reaction mechanism of human nicotinamide phosphoribosyltransferase

(2009) Ryo Takahashi et al.   JOURNAL OF BIOCHEMISTRY

Animal models of chemotherapy-evoked painful peripheral neuropathies

(2009) Nicolas Authier et al.   Neurotherapeutics

A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT

(2009) E. S. Burgos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Weak Coupling of ATP Hydrolysis to the Chemical Equilibrium of Human Nicotinamide Phosphoribosyltransferase†

(2008) Emmanuel S. Burgos et al.   BIOCHEMISTRY

Chemotherapy-induced neuropathy

(2008) Anthony J. Windebank et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Vascularization of the Dorsal Root Ganglia and Peripheral Nerve of the Mouse: Implications for Chemical-Induced Peripheral Sensory Neuropathies

(2008) Juan M Jimenez-Andrade et al.   Molecular Pain

Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-l-carnitine: Effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells

(2007) Hai Wei Jin et al.   EXPERIMENTAL NEUROLOGY

Chemotherapy-evoked neuropathic pain: Abnormal spontaneous discharge in A-fiber and C-fiber primary afferent neurons and its suppression by acetyl-l-carnitine

(2007) Wen Hua Xiao et al.   PAIN