Neurodegenerative Proteinopathies in the Proteoform Spectrum—Tools and Challenges

Characterization of Anchorless Human PrP With Q227X Stop Mutation Linked to Gerstmann-Sträussler-Scheinker Syndrome In Vivo and In Vitro

(2020) Pingping Shen et al.   MOLECULAR NEUROBIOLOGY

Modeling PrPSc Generation Through Deformed Templating

(2020) Giovanni Spagnolli et al.   Frontiers in Bioengineering and Biotechnology

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

(2019) Masaya Ikegawa et al.   Jove-Journal of Visualized Experiments

Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates

(2019) Tom Scheidt et al.   Science Advances

Alzheimer’s disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation

(2019) Cathrine Petersen et al.   ACTA NEUROPATHOLOGICA

Structural Mechanism of Barriers for Interspecies Seeding Transmissibility of Full‐length Prion Protein Amyloid

(2019) Jun Yang et al.   CHEMBIOCHEM

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

(2019) Glenn R. Masson et al.   NATURE METHODS

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains

(2018) Roderick G. Davis et al.   ANALYTICAL CHEMISTRY

Top-Down Hydrogen–Deuterium Exchange Analysis of Protein Structures Using Ultraviolet Photodissociation

(2018) Nicholas I. Brodie et al.   ANALYTICAL CHEMISTRY

Subventricular Zone Lipidomic Architecture Loss in Huntington's Disease

(2018) Mandana Hunter et al.   JOURNAL OF NEUROCHEMISTRY

Native Top-Down Mass Spectrometry and Ion Mobility MS for Characterizing the Cobalt and Manganese Metal Binding of α-Synuclein Protein

(2018) Piriya Wongkongkathep et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

How many human proteoforms are there?

(2018) Ruedi Aebersold et al.   Nature Chemical Biology

Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease

(2018) Diego Grassi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Imaging Mass Spectrometry for Probing Neuronal Protein Dynamics in Neurodegenerative Disease Pathology

(2018) Wojciech Michno et al.   JOURNAL OF NEUROCHEMISTRY

Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator

(2018) Michael Nshanian et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Structural attributes of mammalian prion infectivity: Insights from studies with synthetic prions

(2018) Qiuye Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein identification strategies in MALDI imaging mass spectrometry: a brief review

(2018) Daniel J Ryan et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Parkinson’s Disease: From Pathogenesis to Pharmacogenomics

(2017) Ramón Cacabelos   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry

(2017) Richard Y.-C. Huang et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

(2017) Wei Qiang et al.   NATURE

Aβ seeds and prions: How close the fit?

(2017) Jay Rasmussen et al.   Prion

MALDI Mass Spectrometry Imaging: A Novel Tool for the Identification and Classification of Amyloidosis

(2017) Martin Winter et al.   PROTEOMICS

Species-dependent structural polymorphism of Y145Stop prion protein amyloid revealed by solid-state NMR spectroscopy

(2017) Theint Theint et al.   Nature Communications

Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

(2017) Sebastian Palmqvist et al.   Nature Communications

Prion strains in mammals: Different conformations leading to disease

(2017) Rodrigo Morales   PLoS Pathogens

Alzheimer’s Disease: From Genetic Variants to the Distinct Pathological Mechanisms

(2017) Qiying Sun et al.   Frontiers in Molecular Neuroscience

Distinct deposition of amyloid-β species in brains with Alzheimer’s disease pathology visualized with MALDI imaging mass spectrometry

(2017) Nobuto Kakuda et al.   Acta Neuropathologica Communications

Differential Incorporation of Tau Isoforms in Alzheimer's Disease

(2017) Marisol Espinoza et al.   JOURNAL OF ALZHEIMERS DISEASE

Post-translational modifications in PrP expand the conformational diversity of prions in vivo

(2017) Patricia Aguilar-Calvo et al.   Scientific Reports

Ultra-High Mass Resolution MALDI Imaging Mass Spectrometry of Proteins and Metabolites in a Mouse Model of Glioblastoma

(2017) M. Dilillo et al.   Scientific Reports

Emergence of Alternative Structures in Amyloid Beta 1-42 Monomeric Landscape by N-terminal Hexapeptide Amyloid Inhibitors

(2017) Srirupa Chakraborty et al.   Scientific Reports

Diversity of Amyloid-beta Proteoforms in the Alzheimer’s Disease Brain

(2017) Norelle C. Wildburger et al.   Scientific Reports

Can the age at onset give a clue to the pathogenesis of ALS?

(2016) Vittorio Govoni et al.   ACTA NEUROLOGICA BELGICA

Progress in Top-Down Proteomics and the Analysis of Proteoforms

(2016) Timothy K. Toby et al.   Annual Review of Analytical Chemistry

The Differential Diagnosis and Treatment of Atypical Parkinsonism

(2016) Johannes Levin et al.   Deutsches Arzteblatt International

Differential Membrane Toxicity of Amyloid-β Fragments by Pore Forming Mechanisms

(2016) Christian Peters et al.   JOURNAL OF ALZHEIMERS DISEASE

Comparison of capillary electrophoresis and capillary liquid chromatography coupled to mass spectrometry for the analysis of transthyretin in human serum

(2016) Laura Pont et al.   JOURNAL OF CHROMATOGRAPHY A

Probing amyloid-β pathology in transgenic Alzheimer's disease (tgArcSwe) mice using MALDI imaging mass spectrometry

(2016) Louise Carlred et al.   JOURNAL OF NEUROCHEMISTRY

Tauopathies as clinicopathological entities

(2016) David J. Irwin   PARKINSONISM & RELATED DISORDERS

An Amyloid-Like Pathological Conformation of TDP-43 Is Stabilized by Hypercooperative Hydrogen Bonds

(2016) Miguel Mompeán et al.   Frontiers in Molecular Neuroscience

Soluble Amyloid-beta Aggregates from Human Alzheimer’s Disease Brains

(2016) Thomas J. Esparza et al.   Scientific Reports

Mutation in the 3’untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy

(2015) Gaël Nicolas et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Partially Unfolded Forms of the Prion Protein Populated under Misfolding-promoting Conditions

(2015) Roumita Moulick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Creutzfeldt-Jakob disease: updated diagnostic criteria, treatment algorithm, and the utility of brain biopsy

(2015) Marc Manix et al.   Neurosurgical Focus

Prions and Prion-like Proteins

(2014) Paul E. Fraser   JOURNAL OF BIOLOGICAL CHEMISTRY

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proteomic Screening for Amyloid Proteins

(2014) Anton A. Nizhnikov et al.   PLoS One

Applying the tools of chemistry (mass spectrometry and covalent modification by small molecule reagents) to the detection of prions and the study of their structure

(2014) Christopher J Silva   Prion

Quantitative analysis of human salivary gland-derived intact proteome using top-down mass spectrometry

(2014) Si Wu et al.   PROTEOMICS

Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry

(2014) John F. Kellie et al.   Scientific Reports

Prion Strains and Amyloid Polymorphism Influence Phenotypic Variation

(2014) Kevin C. Stein et al.   PLoS Pathogens

Systemic delivery of P42 peptide: a new weapon to fight Huntington’s disease

(2014) Yoan Arribat et al.   Acta Neuropathologica Communications

Microtubule-associated protein tau in bovine retinal photoreceptor rod outer segments: Comparison with brain tau

(2013) Akio Yamazaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Modelling amyloid fibril formation kinetics: mechanisms of nucleation and growth

(2013) J E Gillam et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Pulsed hydrogen–deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Aβ) peptide aggregation

(2013) Ying Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential toxicity, conformation and morphology of typical initial aggregation states of Aβ1-42 and Aβpy3-42 beta-amyloids

(2012) Denise Galante et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Two-dimensional gel electrophoresis in proteomics: A tutorial

(2011) Thierry Rabilloud et al.   Journal of Proteomics

Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange

(2011) Vytautas Smirnovas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Small Changes, Big Impact

(2011) Dagmar E. Ehrnhoefer et al.   NEUROSCIENTIST

Unfolding of the Amyloid β-Peptide Central Helix: Mechanistic Insights from Molecular Dynamics Simulations

(2011) Mika Ito et al.   PLoS One

Clinical Features of Rapidly Progressive Alzheimer’s Disease

(2010) Christian Schmidt et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

A Quantitative Study of the Effects of Chaotropic Agents, Surfactants, and Solvents on the Digestion Efficiency of Human Plasma Proteins by Trypsin

(2010) Jennifer L. Proc et al.   JOURNAL OF PROTEOME RESEARCH

Highlights on the capacities of "Gel-based" proteomics

(2010) François Chevalier   Proteome Science

CSF tau proteins in differential diagnosis of dementia

(2010) Marina Boban et al.   Translational Neuroscience

A Common Property of Amyotrophic Lateral Sclerosis-associated Variants

(2009) Kathleen S. Molnar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyotrophic lateral sclerosis

(2009) Lokesh C Wijesekera et al.   Orphanet Journal of Rare Diseases

Two-dimensional electrophoresis-based characterization of post-translational modifications of mammalian 20S proteasome complexes

(2008) Chenggong Zong et al.   PROTEOMICS

Urea modulation of β-amyloid fibril growth: Experimental studies and kinetic models

(2004) Jin Ryoun Kim et al.   PROTEIN SCIENCE

The role of protein stability, solubility, and net charge in amyloid fibril formation

(2003) Jason P. Schmittschmitt et al.   PROTEIN SCIENCE