Native Top-Down Mass Spectrometry and Ion Mobility MS for Characterizing the Cobalt and Manganese Metal Binding of α-Synuclein Protein

Supramolecular Modulation of Structural Polymorphism in Pathogenic α-Synuclein Fibrils Using Copper(II) Coordination

(2018) Tae Su Choi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Surface Induced Dissociation Coupled with High Resolution Mass Spectrometry Unveils Heterogeneity of a 211 kDa Multicopper Oxidase Protein Complex

(2018) Mowei Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes

(2018) Huilin Li et al.   Nature Chemistry

Effects of Multidentate Metal Interactions on the Structure of Collisionally Activated Proteins: Insights from Ion Mobility Spectrometry and Molecular Dynamics Simulations

(2016) Claire E. Bartman et al.   ANALYTICAL CHEMISTRY

Structure of the toxic core of α-synuclein from invisible crystals

(2015) Jose A. Rodriguez et al.   NATURE

Probing Conformational Change of Intrinsically Disordered α-Synuclein to Helical Structures by Distinctive Regional Interactions with Lipid Membranes

(2014) Shin Jung C. Lee et al.   ANALYTICAL CHEMISTRY

A Revised Picture of the Cu(II)−α-Synuclein Complex: The Role of N-Terminal Acetylation

(2014) Gina M. Moriarty et al.   BIOCHEMISTRY

Molecular Basis for Preventing α-Synuclein Aggregation by a Molecular Tweezer

(2014) Srabasti Acharya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Native Protein Complexes Using Ultraviolet Photodissociation Mass Spectrometry

(2014) John P. O’Brien et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Revealing Ligand Binding Sites and Quantifying Subunit Variants of Noncovalent Protein Complexes in a Single Native Top-Down FTICR MS Experiment

(2014) Huilin Li et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

What Protein Charging (and Supercharging) Reveal about the Mechanism of Electrospray Ionization

(2014) Rachel R. Ogorzalek Loo et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Membrane proteins bind lipids selectively to modulate their structure and function

(2014) Arthur Laganowsky et al.   NATURE

Ion mobility–mass spectrometry of a rotary ATPase reveals ATP-induced reduction in conformational flexibility

(2014) Min Zhou et al.   Nature Chemistry

The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics

(2014) Francesco Lanucara et al.   Nature Chemistry

N-Alpha-Acetylation of α-Synuclein Increases Its Helical Folding Propensity, GM1 Binding Specificity and Resistance to Aggregation

(2014) Tim Bartels et al.   PLoS One

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

(2014) Jacqueline Burré et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Native Top-Down Electrospray Ionization-Mass Spectrometry of 158 kDa Protein Complex by High-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

(2013) Huilin Li et al.   ANALYTICAL CHEMISTRY

Ion Mobility Analysis of Molecular Dynamics

(2013) Thomas Wyttenbach et al.   Annual Review of Physical Chemistry

Binding of Dopamine to Alpha-Synuclein is Mediated by Specific Conformational States

(2013) Eva Illes-Toth et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Curcumin Modulates α-Synuclein Aggregation and Toxicity

(2012) Pradeep K. Singh et al.   ACS Chemical Neuroscience

Coordination of Copper to the Membrane-Bound Form of α-Synuclein

(2012) Christopher G. Dudzik et al.   BIOCHEMISTRY

Impact of N-Terminal Acetylation of α-Synuclein on Its Random Coil and Lipid Binding Properties

(2012) Alexander S. Maltsev et al.   BIOCHEMISTRY

Bioinorganic chemistry of copper coordination to alpha-synuclein: Relevance to Parkinson's disease

(2012) Andrés Binolfi et al.   COORDINATION CHEMISTRY REVIEWS

Peculiarities of Copper Binding to α-Synuclein

(2012) Atta Ahmad et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Charge-State Dependent Compaction and Dissociation of Protein Complexes: Insights from Ion Mobility and Molecular Dynamics

(2012) Zoe Hall et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Do Charge State Signatures Guarantee Protein Conformations?

(2012) Zoe Hall et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo

(2012) Shubhangi Prabhudesai et al.   Neurotherapeutics

Coordination Features and Affinity of the Cu2+Site in the α-Synuclein Protein of Parkinson’s Disease

(2011) Christopher G. Dudzik et al.   BIOCHEMISTRY

Reflections on Charge State Distributions, Protein Structure, and the Mystical Mechanism of Electrospray Ionization

(2011) Omar M. Hamdy et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering

(2011) Pau Bernadó et al.   Molecular BioSystems

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Structures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation

(2011) Minglei Zhao et al.   PROTEIN SCIENCE

Collision Cross Sections of Proteins and Their Complexes: A Calibration Framework and Database for Gas-Phase Structural Biology

(2010) Matthew F. Bush et al.   ANALYTICAL CHEMISTRY

Top-down mass spectrometry of supercharged native protein–ligand complexes

(2010) Sheng Yin et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Elucidating the site of protein-ATP binding by top-down mass spectrometry

(2010) Sheng Yin et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Compact conformations of α-synuclein induced by alcohols and copper

(2010) Antonino Natalello et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Metal binding to alpha-synuclein peptides and its contribution to toxicity

(2009) David R. Brown   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gas-Phase Unfolding and Disassembly Reveals Stability Differences in Ligand-Bound Multiprotein Complexes

(2009) Suk-Joon Hyung et al.   CHEMISTRY & BIOLOGY

Structural insights on physiological functions and pathological effects of α-synuclein

(2008) Marco Bisaglia et al.   FASEB JOURNAL

Charge state dependent fragmentation of gaseous α-synuclein cations via ion trap and beam-type collisional activation

(2008) Chamnongsak Chanthamontri et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Molecular Understanding of Copper and Iron Interaction with α-Synuclein by Fluorescence Analysis

(2008) Bharathi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Site-Specific Interactions of Cu(II) with α and β-Synuclein: Bridging the Molecular Gap between Metal Binding and Aggregation

(2008) Andrés Binolfi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mass spectrometry of protein-ligand complexes: Enhanced gas-phase stability of ribonuclease-nucleotide complexes

(2008) Sheng Yin et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Do Ionic Charges in ESI MS Provide Useful Information on Macromolecular Structure?

(2008) I KALTASHOV et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Ion mobility–mass spectrometry analysis of large protein complexes

(2008) Brandon T Ruotolo et al.   Nature Protocols

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The fold of  -synuclein fibrils

(2008) M. Vilar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA