How the AHR Became Important in Cancer: The Role of Chronically Active AHR in Cancer Aggression

Modulation of aryl hydrocarbon receptor inhibits esophageal squamous cell carcinoma progression by repressing COX2/PGE2/STAT3 axis

(2020) Peiyao Zhu et al.   Journal of Cell Communication and Signaling

Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression

(2020) Sara Huerta-Yepez et al.   Scientific Reports

The aryl hydrocarbon receptor promotes inflammation‐induced dedifferentiation and systemic metastatic spread of melanoma cells

(2020) Miriam Mengoni et al.   INTERNATIONAL JOURNAL OF CANCER

Role of Flavonoids in the Prevention of AhR-Dependent Resistance During Treatment with BRAF Inhibitors

(2020) Héloïse M. Leclair et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

3,3′-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway

(2020) Peiyao Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

SHROOM2 inhibits tumor metastasis through RhoA–ROCK pathway-dependent and -independent mechanisms in nasopharyngeal carcinoma

(2019) Jing Yuan et al.   Cell Death & Disease

The Prognostic Impact of the Aryl Hydrocarbon Receptor (AhR) in Primary Breast Cancer Depends on the Lymph Node Status

(2019) Udo Jeschke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Opposite Effect of L-kynurenine and Ahr Inhibitor Ch223191 on Apoptotic Protein Expression in Pancreatic Carcinoma Cells (Panc-1)

(2019) Anna Leja-Szpak et al.   Anti-Cancer Agents in Medicinal Chemistry

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

(2019) Maisa C. Takenaka et al.   NATURE NEUROSCIENCE

Diminished AHR signaling drives human acute myeloid leukemia stem cell maintenance

(2019) Michelle Ly et al.   CANCER RESEARCH

Role of the Aryl Hydrocarbon Receptor in Environmentally Induced Skin Aging and Skin Carcinogenesis

(2019) Christian Vogeley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aryl hydrocarbon receptor (AhR) regulates adipocyte differentiation by assembling CRL4B ubiquitin ligase to target PPARγ for proteasomal degradation

(2019) Hao Dou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The aryl hydrocarbon receptor (AhR) as a breast cancer drug target

(2019) Jennifer R. Baker et al.   MEDICINAL RESEARCH REVIEWS

The role of AhR in transcriptional regulation of immune cell development and function

(2019) Prashant Trikha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

p23 protects the human aryl hydrocarbon receptor from degradation via a heat shock protein 90-independent mechanism

(2018) Beverly Pappas et al.   BIOCHEMICAL PHARMACOLOGY

The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis

(2018) Marius Pollet et al.   CELL DEATH AND DIFFERENTIATION

Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor

(2018) Supraja Narasimhan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High AHR expression in breast tumors correlates with expression of genes from several signaling pathways namely inflammation and endogenous tryptophan metabolism

(2018) Sophie Vacher et al.   PLoS One

Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells

(2018) Amy Leung et al.   STEM CELLS

Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance

(2018) Bin Yan et al.   Cell Death & Disease

Constitutive Activation of the Human Aryl Hydrocarbon Receptor in Mice Promotes Hepatocarcinogenesis Independent of Its Coactivator Gadd45b

(2018) Peipei Lu et al.   TOXICOLOGICAL SCIENCES

Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma

(2018) Sébastien Corre et al.   Nature Communications

Inflammatory breast cancer: Activation of the aryl hydrocarbon receptor and its target CYP1B1 correlates closely with Wnt5a/b-β-catenin signalling, the stem cell phenotype and disease progression

(2018) Hossam T. Mohamed et al.   Journal of Advanced Research

Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR)

(2017) Seung-Hyeon Seok et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation

(2017) Abdullah Al-Dhfyan et al.   Molecular Cancer

Macrophages induce EMT to promote invasion of lung cancer cells through the IL-6-mediated COX-2/PGE 2 /β-catenin signalling pathway

(2017) Dehai Che et al.   MOLECULAR IMMUNOLOGY

Paclitaxel-mediated human aryl hydrocarbon receptor mRNA translation by an internal ribosomal entry site-dependent mechanism

(2017) Wen-Qing Gao et al.   ONCOLOGY REPORTS

Targeting STUB1–tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk

(2017) Moshe Shashar et al.   Science Translational Medicine

Aryl hydrocarbon receptor signaling involved in the invasiveness of LNCaP cells

(2017) Hisamitsu Ide et al.   Human Cell

The aryl hydrocarbon receptor is required for induction of p21cip1/waf1 expression and growth inhibition by SU5416 in hepatoma cells

(2017) Edmond F. O’Donnell et al.   Oncotarget

The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells

(2016) Elizabeth A. Stanford et al.   BMC BIOLOGY

Phase I/II Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone Graft

(2016) John E. Wagner et al.   Cell Stem Cell

Tolerogenic Phenotype of IFN-γ–Induced IDO+Dendritic Cells Is Maintained via an Autocrine IDO–Kynurenine/AhR–IDO Loop

(2016) Qingsheng Li et al.   JOURNAL OF IMMUNOLOGY

Divergent Ah Receptor Ligand Selectivity during Hominin Evolution

(2016) Troy D. Hubbard et al.   MOLECULAR BIOLOGY AND EVOLUTION

Role for the Aryl Hydrocarbon Receptor and Diverse Ligands in Oral Squamous Cell Carcinoma Migration and Tumorigenesis

(2016) E. A. Stanford et al.   MOLECULAR CANCER RESEARCH

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Delayed effects of developmental exposure to low levels of the aryl hydrocarbon receptor agonist 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) on adult zebrafish behavior

(2016) Lilah Glazer et al.   NEUROTOXICOLOGY

HRG/HER2/HER3 signaling promotes AhR-mediated Memo-1 expression and migration in colorectal cancer

(2016) V Bogoevska et al.   ONCOGENE

Ah receptor expression in cardiomyocytes protects adult female mice from heart dysfunction induced by TCDD exposure

(2016) Hisaka Kurita et al.   TOXICOLOGY

Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer

(2016) Jieqi Ke et al.   TUMOR BIOLOGY

CYP1B1 Enhances Cell Proliferation and Metastasis through Induction of EMT and Activation of Wnt/β-Catenin Signaling via Sp1 Upregulation

(2016) Yeo-Jung Kwon et al.   PLoS One

The Aryl Hydrocarbon Receptor is a Critical Regulator of Tissue Factor Stability and an Antithrombotic Target in Uremia

(2015) S. Shivanna et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lipopolysaccharide induces inflammation and facilitates lung metastasis in a breast cancer model via the prostaglandin E2-EP2 pathway

(2015) SHANCHENG LI et al.   Molecular Medicine Reports

The aryl hydrocarbon receptor (AhR) mediates resistance to apoptosis induced in breast cancer cells

(2015) Kanae Bekki et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Tryptophan-Degrading Enzymes in Tumoral Immune Resistance

(2015) Nicolas van Baren et al.   Frontiers in Immunology

Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR

(2015) Ulrike M. Litzenburger et al.   Oncotarget

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

(2015) Troy D. Hubbard et al.   Scientific Reports

Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype

(2015) Gyu-Beom Jang et al.   Scientific Reports

Activation of the aryl hydrocarbon receptor by carcinogenic aromatic amines and modulatory effects of their N-acetylated metabolites

(2014) Ludmila Juricek et al.   ARCHIVES OF TOXICOLOGY

E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition

(2014) Augustine Chen et al.   BMC CANCER

The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis

(2014) Un-Ho Jin et al.   BMC CANCER

Coactivator Recruitment of AhR/ARNT1

(2014) Alexander Endler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production

(2014) Margaret M. Lowe et al.   PLoS One

The Aryl Hydrocarbon Receptor Is Constitutively Active in Advanced Prostate Cancer Cells

(2014) Oliver Richmond et al.   PLoS One

The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation

(2013) B. W. Smith et al.   BLOOD

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Evidence for a novel anti-apoptotic pathway in human keratinocytes involving the aryl hydrocarbon receptor, E2F1 and checkpoint kinase 1

(2013) K Frauenstein et al.   CELL DEATH AND DIFFERENTIATION

Disruption of Aryl Hydrocarbon Receptor Homeostatic Levels during Embryonic Stem Cell Differentiation Alters Expression of Homeobox Transcription Factors that Control Cardiomyogenesis

(2013) Qin Wang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Knockdown of aberrantly upregulated aryl hydrocarbon receptor reduces tumor growth and metastasis of MDA-MB-231 human breast cancer cell line

(2013) Gennifer D. Goode et al.   INTERNATIONAL JOURNAL OF CANCER

Oculomotor Deficits in Aryl Hydrocarbon Receptor Null Mouse

(2013) Aline Chevallier et al.   PLoS One

Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells

(2013) D. M. Gilkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of the aryl hydrocarbon receptor in normal and malignant B cell development

(2013) David H. Sherr et al.   Seminars in Immunopathology

Pluripotency factors and Polycomb Group proteins repress aryl hydrocarbon receptor expression in murine embryonic stem cells

(2013) Chia-I Ko et al.   Stem Cell Research

Loss of Aryl Hydrocarbon Receptor Promotes Gene Changes Associated with Premature Hematopoietic Stem Cell Exhaustion and Development of a Myeloproliferative Disorder in Aging Mice

(2013) Kameshwar P. Singh et al.   STEM CELLS AND DEVELOPMENT

Indoxyl 3-sulfate stimulates Th17 differentiation enhancing phosphorylation of c-Src and STAT3 to worsen experimental autoimmune encephalomyelitis

(2013) Sung-Jun Hwang et al.   TOXICOLOGY LETTERS

Tuning the range and stability of multiple phenotypic states with coupled positive–negative feedback loops

(2013) Maier S. Avendaño et al.   Nature Communications

Src-mediated aryl hydrocarbon and epidermal growth factor receptor cross talk stimulates colon cancer cell proliferation

(2012) Guofeng Xie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Malignant Transformation of Mammary Epithelial Cells by Ectopic Overexpression of the Aryl Hydrocarbon Receptor

(2012) J. Brooks et al.   CURRENT CANCER DRUG TARGETS

Ah Receptor Antagonism Represses Head and Neck Tumor Cell Aggressive Phenotype

(2012) B. C. DiNatale et al.   MOLECULAR CANCER RESEARCH

Src-Mediated Cross-Talk between Farnesoid X and Epidermal Growth Factor Receptors Inhibits Human Intestinal Cell Proliferation and Tumorigenesis

(2012) Zhongsheng Peng et al.   PLoS One

Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor

(2012) E. Wincent et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of aryl hydrocarbon receptor and NF-κB subunit RelB in breast cancer is associated with interleukin-8 overexpression

(2011) Christoph Franz Adam Vogel et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Ligand-independent activation of the arylhydrocarbon receptor by ETK (Bmx) tyrosine kinase helps MCF10AT1 breast cancer cells to survive in an apoptosis-inducing environment

(2011) Yasuko Fujisawa et al.   BIOLOGICAL CHEMISTRY

Immunoglobulin light chain, Blimp-1 and cytochrome P4501B1 peptides as potential vaccines for AL amyloidosis

(2011) Amanda Flies et al.   IMMUNOLOGY AND CELL BIOLOGY

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

(2011) E. A. Kiss et al.   SCIENCE

Aryl Hydrocarbon Receptor Ligands of Widely Different Toxic Equivalency Factors Induce Similar Histone Marks in Target Gene Chromatin

(2011) Jerald L. Ovesen et al.   TOXICOLOGICAL SCIENCES

Dietary Ligands of the Aryl Hydrocarbon Receptor Induce Anti-Inflammatory and Immunoregulatory Effects on Murine Dendritic Cells

(2011) Jenna M. Benson et al.   TOXICOLOGICAL SCIENCES

The Aryl Hydrocarbon Receptor-interacting Protein (AIP) Is Required for Dioxin-induced Hepatotoxicity but Not for the Induction of theCyp1a1andCyp1a2Genes

(2010) Manabu Nukaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Aryl Hydrocarbon Receptor Mediates UVB Radiation–Induced Skin Tanning

(2010) Bettina Jux et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Positive Autoregulation Shapes Response Timing and Intensity in Two-component Signal Transduction Systems

(2010) Alexander Y. Mitrophanov et al.   JOURNAL OF MOLECULAR BIOLOGY

Ah receptor antagonism inhibits constitutive and cytokine inducible IL6 production in head and neck tumor cell lines

(2010) Brett C. DiNatale et al.   MOLECULAR CARCINOGENESIS

Aryl Hydrocarbon Receptor Is a Transcriptional Activator of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

(2010) K. P. Tan et al.   MOLECULAR PHARMACOLOGY

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27

(2010) Lionel Apetoh et al.   NATURE IMMUNOLOGY

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

(2010) N. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

(2010) Anthony E. Boitano et al.   SCIENCE

Aryl Hydrocarbon Receptor-Null Allele Mice Have Hematopoietic Stem/Progenitor Cells with Abnormal Characteristics and Functions

(2010) Kameshwar P. Singh et al.   STEM CELLS AND DEVELOPMENT

Differential Gene Regulation by the Human and Mouse Aryl Hydrocarbon Receptor

(2010) Colin A. Flaveny et al.   TOXICOLOGICAL SCIENCES

Consequences of AhR Activation in Steady-State Dendritic Cells

(2010) T. Simones et al.   TOXICOLOGICAL SCIENCES

CH223191 Is a Ligand-Selective Antagonist of the Ah (Dioxin) Receptor

(2010) Bin Zhao et al.   TOXICOLOGICAL SCIENCES

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

(2010) Brett C. DiNatale et al.   TOXICOLOGICAL SCIENCES

The Uremic Toxin 3-Indoxyl Sulfate Is a Potent Endogenous Agonist for the Human Aryl Hydrocarbon Receptor

(2009) Jennifer C. Schroeder et al.   BIOCHEMISTRY

Aryl hydrocarbon receptor pathway activation enhances gastric cancer cell invasiveness likely through a c-Jun-dependent induction of matrix metalloproteinase-9

(2009) Tie-Li Peng et al.   BMC CELL BIOLOGY

Activation of the aryl hydrocarbon receptor pathway enhances cancer cell invasion by upregulating the MMP expression and is associated with poor prognosis in upper urinary tract urothelial cancer

(2009) M. Ishida et al.   CARCINOGENESIS

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer

(2009) E. Charafe-Jauffret et al.   CLINICAL CANCER RESEARCH

Direct Assessment of Cumulative Aryl Hydrocarbon Receptor Agonist Activity in Sera from Experimentally Exposed Mice and Environmentally Exposed Humans

(2009) Jennifer J. Schlezinger et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Evidence for Ligand-Mediated Selective Modulation of Aryl Hydrocarbon Receptor Activity

(2009) I. A. Murray et al.   MOLECULAR PHARMACOLOGY

The mouse and human Ah receptor differ in recognition of LXXLL motifs

(2008) Colin Flaveny et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase

(2008) Christoph F.A. Vogel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations

(2008) Kameshwar P. Singh et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of constitutive and inducible AHR signaling: Complex interactions involving the AHR repressor

(2008) Mark E. Hahn et al.   BIOCHEMICAL PHARMACOLOGY

Positive feedback in cellular control systems

(2008) Alexander Y. Mitrophanov et al.   BIOESSAYS

Targeting cytochrome P450 CYP1B1 with a therapeutic cancer vaccine

(2008) Thomas M Luby   Expert Review of Vaccines

Restoring TGFβ function in microsatellite unstable (MSI-H) colorectal cancer reduces tumourigenicity but increases metastasis formation

(2008) Janindra Warusavitarne et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

The Suggested Physiologic Aryl Hydrocarbon Receptor Activator and Cytochrome P4501 Substrate 6-Formylindolo[3,2-b]carbazole Is Present in Humans

(2008) Emma Wincent et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers

(2008) Enrique Zudaire et al.   JOURNAL OF CLINICAL INVESTIGATION

The Aryl Hydrocarbon Receptor Binds to E2F1 and Inhibits E2F1-induced Apoptosis

(2008) Jennifer L. Marlowe et al.   MOLECULAR BIOLOGY OF THE CELL

Constitutive regulation ofCYP1B1 by the aryl hydrocarbon receptor (AhR) in pre-malignant and malignant mammary tissue

(2007) Xinhai Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay

(2007) Shu Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY