Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells

Conversion of adult endothelium to immunocompetent haematopoietic stem cells

(2017) Raphael Lis et al.   NATURE

Haematopoietic stem and progenitor cells from human pluripotent stem cells

(2017) Ryohichi Sugimura et al.   NATURE

Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells

(2017) Xuejia Li et al.   Stem Cell Research

The aryl hydrocarbon receptor is required for induction of p21cip1/waf1 expression and growth inhibition by SU5416 in hepatoma cells

(2017) Edmond F. O’Donnell et al.   Oncotarget

Fetal and adult progenitors give rise to unique populations of CD8+ T cells

(2016) J. Wang et al.   BLOOD

Directed differentiation of definitive hemogenic endothelium and hematopoietic progenitors from human pluripotent stem cells

(2016) Andrea Ditadi et al.   METHODS

Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros

(2016) Elizabeth S Ng et al.   NATURE BIOTECHNOLOGY

Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts

(2016) Divya S. Vinjamur et al.   PLoS One

Dysregulation of Notch and ERα signaling in AhR−/−male mice

(2016) Bo Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity

(2016) Yi-Fen Lu et al.   Cell Reports

BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo

(2016) Mihaela Crisan et al.   Stem Cell Reports

Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells

(2015) Jennifer L. Gori et al.   JOURNAL OF CLINICAL INVESTIGATION

Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages

(2015) Andrea Ditadi et al.   NATURE CELL BIOLOGY

In Vivo Repopulating Activity Emerges at the Onset of Hematopoietic Specification during Embryonic Stem Cell Differentiation

(2015) Stella Pearson et al.   Stem Cell Reports

Effect of Developmental Stage of HSC and Recipient on Transplant Outcomes

(2014) Natasha Arora et al.   DEVELOPMENTAL CELL

Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells

(2014) Christopher M Sturgeon et al.   NATURE BIOTECHNOLOGY

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

(2014) I. Fares et al.   SCIENCE

Tenascin C Promotes Hematoendothelial Development and T Lymphoid Commitment from Human Pluripotent Stem Cells in Chemically Defined Conditions

(2014) Gene Uenishi et al.   Stem Cell Reports

Identification of the Niche and Phenotype of the First Human Hematopoietic Stem Cells

(2014) Andrejs Ivanovs et al.   Stem Cell Reports

The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation

(2013) B. W. Smith et al.   BLOOD

Heterogeneity of young and aged murine hematopoietic stem cells revealed by quantitative clonal analysis using cellular barcoding

(2013) E. Verovskaya et al.   BLOOD

Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells

(2013) J. B. Lee et al.   BLOOD

In Vivo Mapping of Notch Pathway Activity in Normal and Stress Hematopoiesis

(2013) Philmo Oh et al.   Cell Stem Cell

Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors

(2013) Sergei Doulatov et al.   Cell Stem Cell

Heterogeneity and hierarchy of hematopoietic stem cells

(2013) Hideo Ema et al.   EXPERIMENTAL HEMATOLOGY

Generation of Engraftable Hematopoietic Stem Cells From Induced Pluripotent Stem Cells by Way of Teratoma Formation

(2013) Nao Suzuki et al.   MOLECULAR THERAPY

Establishment of Immortalized Human Erythroid Progenitor Cell Lines Able to Produce Enucleated Red Blood Cells

(2013) Ryo Kurita et al.   PLoS One

Loss of Aryl Hydrocarbon Receptor Promotes Gene Changes Associated with Premature Hematopoietic Stem Cell Exhaustion and Development of a Myeloproliferative Disorder in Aging Mice

(2013) Kameshwar P. Singh et al.   STEM CELLS AND DEVELOPMENT

In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells

(2012) G. Amabile et al.   BLOOD

The Transcriptional Landscape of Hematopoietic Stem Cell Ontogeny

(2012) Shannon McKinney-Freeman et al.   Cell Stem Cell

The Notch Ligand Delta-Like 4 Regulates Multiple Stages of Early Hemato-Vascular Development

(2012) Ricardo Laranjeiro et al.   PLoS One

T Lymphocyte Potential Marks the Emergence of Definitive Hematopoietic Progenitors in Human Pluripotent Stem Cell Differentiation Cultures

(2012) Marion Kennedy et al.   Cell Reports

Novel, High-Yield Red Blood Cell Production Methods from CD34-Positive Cells Derived from Human Embryonic Stem, Yolk Sac, Fetal Liver, Cord Blood, and Peripheral Blood

(2012) Emmanuel Olivier et al.   Stem Cells Translational Medicine

From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications

(2011) S. M. Hattangadi et al.   BLOOD

The aryl hydrocarbon receptor (AHR) transcription factor regulates megakaryocytic polyploidization

(2011) Stephan Lindsey et al.   BRITISH JOURNAL OF HAEMATOLOGY

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

(2011) Jacob S Lee et al.   NATURE IMMUNOLOGY

Production of Embryonic and Fetal-Like Red Blood Cells from Human Induced Pluripotent Stem Cells

(2011) Chan-Jung Chang et al.   PLoS One

Generation of Red Blood Cells from Human Induced Pluripotent Stem Cells

(2011) Jessica Dias et al.   STEM CELLS AND DEVELOPMENT

Notch signaling distinguishes 2 waves of definitive hematopoiesis in the zebrafish embryo

(2010) J. Y. Bertrand et al.   BLOOD

KLF1 regulates BCL11A expression and γ- to β-globin gene switching

(2010) Dewang Zhou et al.   NATURE GENETICS

Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

(2010) Anthony E. Boitano et al.   SCIENCE

Generation of Transgene-Free Lung Disease-Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette

(2010) Aba Somers et al.   STEM CELLS

Aryl Hydrocarbon Receptor-Null Allele Mice Have Hematopoietic Stem/Progenitor Cells with Abnormal Characteristics and Functions

(2010) Kameshwar P. Singh et al.   STEM CELLS AND DEVELOPMENT

Notch signalling and haematopoietic stem cell formation during embryogenesis

(2009) Martin Gering et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

Developmental and species-divergent globin switching are driven by BCL11A

(2009) Vijay G. Sankaran et al.   NATURE

The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations

(2008) Kameshwar P. Singh et al.   BIOCHEMICAL PHARMACOLOGY

Wnt, Activin, and BMP Signaling Regulate Distinct Stages in the Developmental Pathway from Embryonic Stem Cells to Blood

(2008) M. Cristina Nostro et al.   Cell Stem Cell

BMP and Wnt Specify Hematopoietic Fate by Activation of the Cdx-Hox Pathway

(2008) Claudia Lengerke et al.   Cell Stem Cell

The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF

(2008) S. Pearson et al.   DEVELOPMENT

Molecular mechanisms of p21 and p27 induction by 3-methylcholanthrene, an aryl-hydrocarbon receptor agonist, involved in antiproliferation of human umbilical vascular endothelial cells

(2007) Pai-Huei Pang et al.   JOURNAL OF CELLULAR PHYSIOLOGY