Aryl hydrocarbon receptor (AhR) regulates adipocyte differentiation by assembling CRL4B ubiquitin ligase to target PPARγ for proteasomal degradation

The world of protein acetylation

(2016) Adrian Drazic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

PPARγ neddylation essential for adipogenesis is a potential target for treating obesity

(2016) H-S Park et al.   CELL DEATH AND DIFFERENTIATION

Lack of CUL4B in Adipocytes Promotes PPARγ-Mediated Adipose Tissue Expansion and Insulin Sensitivity

(2016) Peishan Li et al.   DIABETES

The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1E3 ligase

(2016) Beezly S Groh et al.   EMBO REPORTS

Aryl Hydrocarbon Receptor Plays Protective Roles against High Fat Diet (HFD)-induced Hepatic Steatosis and the Subsequent Lipotoxicity via Direct Transcriptional Regulation ofSocs3Gene Expression

(2016) Taira Wada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bidirectional communication between the Aryl hydrocarbon Receptor (AhR) and the microbiome tunes host metabolism

(2016) Agata Korecka et al.   npj Biofilms and Microbiomes

Ubiquitin Ligase NEDD4 Regulates PPARγ Stability and Adipocyte Differentiation in 3T3-L1 Cells

(2016) Jing Jing Li et al.   Scientific Reports

Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B

(2015) Jeffrey Hannah et al.   GENE

Activation of aryl hydrocarbon receptor dissociates fatty liver from insulin resistance by inducing fibroblast growth factor 21

(2015) Peipei Lu et al.   HEPATOLOGY

Aryl hydrocarbon receptor deficiency protects mice from diet-induced adiposity and metabolic disorders through increased energy expenditure

(2015) C-X Xu et al.   INTERNATIONAL JOURNAL OF OBESITY

The ubiquitin ligase Siah2 regulates obesity-induced adipose tissue inflammation

(2015) Gail Kilroy et al.   Obesity

The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ

(2015) Masashi Watanabe et al.   eLife

Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

(2015) Rafael Mayoral et al.   Molecular Metabolism

Acetylation-defective mutants of Pparγ are associated with decreased lipid synthesis in breast cancer cells

(2015) Lifeng Tian et al.   Oncotarget

Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease

(2014) Un Jung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sumoylation of Peroxisome Proliferator-Activated Receptor   by Apoptotic Cells Prevents Lipopolysaccharide-Induced NCoR Removal from  B Binding Sites Mediating Transrepression of Proinflammatory Cytokines

(2014) C. Jennewein et al.   JOURNAL OF IMMUNOLOGY

Research Resource: Comparison of Gene Profiles From Wild-Type ERα and ERα Hinge Region Mutants

(2014) Katherine A. Burns et al.   MOLECULAR ENDOCRINOLOGY

Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner

(2014) R. Chodankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation

(2013) J-H Kim et al.   CELL DEATH AND DIFFERENTIATION

Evaluation of the Association between Persistent Organic Pollutants (POPs) and Diabetes in Epidemiological Studies: A National Toxicology Program Workshop Review

(2013) Kyla W. Taylor et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Upregulation of SIRT1 by 17β-estradiol depends on ubiquitin-proteasome degradation of PPAR-γ mediated by NEDD4-1

(2013) Limin Han et al.   Protein & Cell

CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis

(2012) Huili Hu et al.   CANCER CELL

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

General Molecular Biology and Architecture of Nuclear Receptors

(2012) Michal Pawlak et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Ubiquitin Ligase Siah2 Regulates PPARγ Activity in Adipocytes

(2012) Gail Kilroy et al.   ENDOCRINOLOGY

Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl

(2012) Hao Dou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lack of Cul4b, an E3 Ubiquitin Ligase Component, Leads to Embryonic Lethality and Abnormal Placental Development

(2012) Baichun Jiang et al.   PLoS One

Regulation of Androgen Receptor-dependent Transcription by Coactivator MED1 Is Mediated through a Newly Discovered Noncanonical Binding Motif

(2011) Feng Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Forming functional fat: a growing understanding of adipocyte differentiation

(2011) Ana G. Cristancho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear transport of peroxisome-proliferator activated receptor  

(2010) F. Iwamoto et al.   JOURNAL OF BIOCHEMISTRY

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Characterization of Nuclear Localization Signal in the N Terminus of CUL4B and Its Essential Role in Cyclin E Degradation and Cell Cycle Progression

(2009) Yongxin Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obesity, inflammation, and atherosclerosis

(2009) Viviane Z. Rocha et al.   Nature Reviews Cardiology

Posttranslational Modifications of PPAR-γ: Fine-tuning the Metabolic Master Regulator

(2009) Olivier van Beekum et al.   Obesity

CRL4s: the CUL4-RING E3 ubiquitin ligases

(2009) Sarah Jackson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural Basis of UV DNA-Damage Recognition by the DDB1–DDB2 Complex

(2008) Andrea Scrima et al.   CELL

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

(2008) Yi Liu et al.   NATURE