New 1,3,4-Oxadiazole Derivatives of Pyridothiazine-1,1-Dioxide with Anti-Inflammatory Activity

Design, Synthesis, and Biological Evaluation of 2‐(2‐Bromo‐3‐nitrophenyl)‐5‐phenyl‐1,3,4‐oxadiazole Derivatives as Possible Anti‐Breast Cancer Agents

(2020) Arjun H. Ananth et al.   CHEMISTRY & BIODIVERSITY

Diversity-oriented synthesis and antifungal activities of novel pimprinine derivative bearing a 1,3,4-oxadiazole-5-thioether moiety

(2020) Zi-Long Song et al.   MOLECULAR DIVERSITY

Design, Synthesis and In Vitro Characterization of Novel Antimicrobial Agents Based on 6-Chloro-9H-carbazol Derivatives and 1,3,4-Oxadiazole Scaffolds

(2020) Alexandra T. Bordei Telehoiu et al.   MOLECULES

Effect of Novel Pyrrolo[3,4-d]pyridazinone Derivatives on Lipopolysaccharide-Induced Neuroinflammation

(2020) Karolina Wakulik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis and anticancer evaluation of new lipophilic 1,2,4 and 1,3,4-oxadiazoles

(2019) Wiliam Caneschi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of 1,3,4-oxadiazole derivatives for development as broad-spectrum antibiotics

(2019) Cédric Tresse et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and molecular docking of benzophenone conjugated with oxadiazole sulphur bridge pyrazole pharmacophores as anti inflammatory and analgesic agents

(2019) Zabiulla et al.   BIOORGANIC CHEMISTRY

Synthesis, molecular modelling studies and ADME prediction of benzothiazole clubbed oxadiazole-Mannich bases, and evaluation of their anti-diabetic activity through in vivo model

(2018) Rubina Bhutani et al.   BIOORGANIC CHEMISTRY

Synthesis, thymidine phosphorylase inhibitory and computational study of novel 1,3,4-oxadiazole-2-thione derivatives as potential anticancer agents

(2018) Shalini Bajaj et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Hypoxia, oxidative stress and inflammation

(2018) Trudy McGarry et al.   FREE RADICAL BIOLOGY AND MEDICINE

Optimization of a 1,3,4-oxadiazole series for inhibition of Ca2+/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain

(2018) Jatinder Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole

(2018) Teresa Glomb et al.   MOLECULES

S -substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents

(2017) Galina Karabanovich et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Oxadiazole-Thiadiazole Hybrids and Their Anticandidal Activity

(2017) Serkan Levent et al.   MOLECULES

Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach

(2016) Anupam G. Banerjee et al.   BIOORGANIC CHEMISTRY

Ultrasound- and Molecular Sieves-Assisted Synthesis, Molecular Docking and Antifungal Evaluation of 5-(4-(Benzyloxy)-substituted phenyl)-3-((phenylamino)methyl)-1,3,4-oxadiazole-2(3H)-thiones

(2016) Urja Nimbalkar et al.   MOLECULES

Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6–diphenyl–1,2,4–triazin–3(2 H )–one derivatives bearing 5–substituted 1,3,4–oxadiazole as potential anti–inflammatory and analgesic agents

(2015) Anupam G. Banerjee et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways

(2015) Nicholas S. Kirkby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design, synthesis, and pharmacological studies of some new Mannich bases and S-alkylated analogs of pyrazole integrated 1,3,4-oxadiazole

(2015) Shivapura Viveka et al.   RESEARCH ON CHEMICAL INTERMEDIATES

2,5-Diaryl-1,3,4-oxadiazoles as selective COX-2 inhibitors and anti-inflammatory agents

(2015) Jagdeep Grover et al.   RSC Advances

Design and Synthesis of Benzimidazole Analogs Endowed with Oxadiazole as Selective COX-2 Inhibitor

(2014) Ankita Rathore et al.   ARCHIV DER PHARMAZIE

Synthesis, pharmacological screening and in silico studies of new class of Diclofenac analogues as a promising anti-inflammatory agents

(2014) Mahesh B. Palkar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity

(2014) Sumit Bansal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network

(2014) Shu Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-Inflammatory, Analgesic Evaluation and Molecular Docking Studies of N-Phenyl Anthranilic Acid-Based 1,3,4-Oxadiazole Analogues

(2013) Suman Bala et al.   Journal of Chemistry

Synthesis and anti-inflammatory activity of novel pyridazine and pyridazinone derivatives as non-ulcerogenic agents

(2012) Makarem M. Saeed et al.   ARCHIVES OF PHARMACAL RESEARCH

Synthesis and Analgesic and Anti-inflammatory Activity of Ethyl (6-Substituted-3(2H)-pyridazinone-2-yl)acetate Derivatives

(2012) Yasemin Dündar et al.   ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent

(2012) Girish D. Hatnapure et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Synthesis, biological evaluation and molecular docking studies of stellatin derivatives as cyclooxygenase (COX-1, COX-2) inhibitors and anti-inflammatory agents

(2011) Raju Gautam et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of Novel Nalidixic Acid-Based 1,3,4-Thiadiazole and 1,3,4-Oxadiazole Derivatives as Potent Antibacterial Agents

(2011) Nisha Aggarwal et al.   Chemical Biology & Drug Design

Oxadiazoles in Medicinal Chemistry

(2011) Jonas Boström et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preventive but Not Curative Efficacy of Celecoxib on Bladder Carcinogenesis in a Rat Model

(2011) José Sereno et al.   MEDIATORS OF INFLAMMATION

Managing the adverse effects of nonsteroidal anti-inflammatory drugs

(2011) Paola Patrignani et al.   Expert Review of Clinical Pharmacology

Anti-inflammatory, anti-proliferative and antioxidant profiles of selective cyclooxygenase-2 inhibition as chemoprevention for rat bladder carcinogenesis

(2010) Belmiro Parada et al.   CANCER BIOLOGY & THERAPY

Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives

(2010) K. Manjunatha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways

(2009) A. J. Schetter et al.   CARCINOGENESIS

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Cyclooxygenase-2 Inhibitors, Nonsteroidal Anti-inflammatory Drugs, and Cardiovascular Risk

(2008) Orly Vardeny et al.   CARDIOLOGY CLINICS

Aroylpropionic acid based 2,5-disubstituted-1,3,4-oxadiazoles: Synthesis and their anti-inflammatory and analgesic activities

(2008) Mymoona Akhter et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Design, Synthesis and Evaluation of Antiinflammatory, Analgesic and Ulcerogenicity studies of Novel S-Substituted phenacyl-1,3,4-oxadiazole-2-thiol and Schiff bases of Diclofenac acid as Nonulcerogenic Derivatives

(2007) Shashikant V. Bhandari et al.   BIOORGANIC & MEDICINAL CHEMISTRY