Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network

Investigating Substrate Promiscuity in Cyclooxygenase-2

(2012) Alex J. Vecchio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes

(2012) Matthew A. Windsor et al.   ACS Medicinal Chemistry Letters

Human Cyclooxygenase-2 Is a Sequence Homodimer That Functions as a Conformational Heterodimer

(2011) Liang Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structural Basis of Endocannabinoid Oxygenation by Cyclooxygenase-2

(2011) Alex J. Vecchio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Force Field with Discrete Displaceable Waters and Desolvation Entropy for Hydrated Ligand Docking

(2011) Stefano Forli et al.   JOURNAL OF MEDICINAL CHEMISTRY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life

(2010) Jane L. Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural Basis of Fatty Acid Substrate Binding to Cyclooxygenase-2

(2010) Alex J. Vecchio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis for Cyclooxygenase Inhibition by the Non-steroidal Anti-inflammatory Drug Naproxen

(2010) Kelsey C. Duggan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

First-Principles Prediction of the pKas of Anti-inflammatory Oxicams

(2010) Junming Ho et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Differential Sensitivity and Mechanism of Inhibition of COX-2 Oxygenation of Arachidonic Acid and 2-Arachidonoylglycerol by Ibuprofen and Mefenamic Acid

(2009) Jeffery J. Prusakiewicz et al.   BIOCHEMISTRY