Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach

Title
Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach
Authors
Keywords
Molecular hybridisation, COX-2, 1,2,4-triazine, 1,3,4-oxadiazole, 1,3,4-thiadiazole, Cardiotoxicity
Journal
BIOORGANIC CHEMISTRY
Volume 69, Issue -, Pages 102-120
Publisher
Elsevier BV
Online
2016-10-15
DOI
10.1016/j.bioorg.2016.10.003

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