Effect of Novel Pyrrolo[3,4-d]pyridazinone Derivatives on Lipopolysaccharide-Induced Neuroinflammation

Recent Advances in Lipopolysaccharide Recognition Systems

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Neuroinflammation and Neurogenesis in Alzheimer’s Disease and Potential Therapeutic Approaches

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What Are the Molecular Mechanisms by Which Functional Bacterial Amyloids Influence Amyloid Beta Deposition and Neuroinflammation in Neurodegenerative Disorders?

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Effect of new olivacine derivatives on p53 protein level

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Impact of HMGB1, RAGE, and TLR4 in Alzheimer’s Disease (AD): From Risk Factors to Therapeutic Targeting

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Brain-Gut-Microbiota Axis in Alzheimer’s Disease

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Superparamagnetic iron oxide nanoparticles combined with NGF and quercetin promote neuronal branching morphogenesis of PC12 cells

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The regulation of mitochondria dynamics in neurite outgrowth by retinoic acid receptor β signaling

(2019) Diogo Trigo et al.   FASEB JOURNAL

Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration

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Synthesis and biological evaluation of pyridazinone derivatives as selective COX-2 inhibitors and potential anti-inflammatory agents

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Anti-Neuroinflammatory Effect of Alantolactone through the Suppression of the NF-κB and MAPK Signaling Pathways

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In Vitro Anti-Inflammatory Effects of Phenolic Compounds from Moraiolo Virgin Olive Oil (MVOO) in Brain Cells via Regulating the TLR4/NLRP3 Axis

(2019) Agnese Taticchi et al.   MOLECULES

Valproic acid attenuates Aβ 25-35 -induced neurotoxicity in PC12 cells through suppression of mitochondria-mediated apoptotic pathway

(2018) Li Zhao et al.   BIOMEDICINE & PHARMACOTHERAPY

Anti-amyloidogenic and anti-apoptotic effect of α-bisabolol against Aβ induced neurotoxicity in PC12 cells

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Integrated communications between cyclooxygenase-2 and Alzheimer’s disease

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Metal Ion Effects on Aβ and Tau Aggregation

(2018) Anne Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer’s Disease—a Critical Review

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Differentiation by nerve growth factor (NGF) involves mechanisms of crosstalk between energy homeostasis and mitochondrial remodeling

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Lipopolysaccharide Associates with Amyloid Plaques, Neurons and Oligodendrocytes in Alzheimer’s Disease Brain: A Review

(2018) Xinhua Zhan et al.   Frontiers in Aging Neuroscience

A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly

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Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders

(2017) Hui Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

NSAIDs as potential treatment option for preventing amyloid β toxicity in Alzheimer’s disease: an investigation by docking, molecular dynamics, and DFT studies

(2017) Faizul Azam et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Salidroside protects PC12 cells from Aβ1–40-induced cytotoxicity by regulating the nicotinamide phosphoribosyltransferase signaling pathway

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RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration

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Lipopolysaccharide (LPS) Accumulates in Neocortical Neurons of Alzheimer’s Disease (AD) Brain and Impairs Transcription in Human Neuronal-Glial Primary Co-cultures

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Metabolic reprogramming during neuronal differentiation

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Inflammatory Mechanisms and Oxidative Stress as Key Factors Responsible for Progression of Neurodegeneration: Role of Brain Innate Immune System

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Gram-negative bacterial molecules associate with Alzheimer disease pathology

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Human gut microbiota: the links with dementia development

(2016) Rashad Alkasir et al.   Protein & Cell

Antinociceptive, anti-inflammatory and smooth muscle relaxant activities of the pyrrolo[3,4-d]pyridazinone derivatives: Possible mechanisms of action

(2015) Szczepan Mogilski et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression

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DEAD-box helicase DP103 defines metastatic potential of human breast cancers

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Impact and Therapeutic Potential of PPARs in Alzheimers Disease

(2011) Michael T. Heneka et al.   Current Neuropharmacology

Derivatives of pyrrolo[3,4-d]pyridazinone, a new class of analgesic agents

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Inhibition of LPS-induced apoptosis in differentiated-PC12 cells by new triazine derivatives through NF-κB-mediated suppression of COX-2

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Studying the effect of LPS on cytotoxicity and apoptosis in PC12 neuronal cells: Role of Bax, Bcl-2, and Caspase-3 protein expression

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Cyclooxygenase-1 and -2 in the Different Stages of Alzheimers Disease Pathology

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Interactions between APP secretases and inflammatory mediators

(2008) Magdalena Sastre et al.   Journal of Neuroinflammation

Pinitol targets nuclear factor-κB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis

(2008) Gautam Sethi et al.   MOLECULAR CANCER THERAPEUTICS