Established and emergent roles for Ikaros transcription factors in lymphoid cell development and function

Innate Lymphoid Cell-Epithelial Cell Modules Sustain Intestinal Homeostasis

(2020) Andreas Diefenbach et al.   IMMUNITY

IKZF3/Aiolos Is Associated with but Not Sufficient for the Expression of IL-10 by CD4+ T Cells

(2020) Michael L. Ridley et al.   JOURNAL OF IMMUNOLOGY

Dynamic Roles for IL-2–STAT5 Signaling in Effector and Regulatory CD4+ T Cell Populations

(2020) Devin M. Jones et al.   JOURNAL OF IMMUNOLOGY

Lack of Ikaros Deregulates Inflammatory Gene Programs in T Cells

(2019) Carolina Lyon de Ana et al.   JOURNAL OF IMMUNOLOGY

Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators control B-cell differentiation

(2019) Toshimi Yoshida et al.   GENES & DEVELOPMENT

Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity

(2019) Yali Ding et al.   LEUKEMIA

Suppression of Aiolos and Ikaros expression by lenalidomide reduces human ILC3−ILC1/NK cell transdifferentiation

(2019) Luca Mazzurana et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Selective deletion of Eos (Ikzf4) in T-regulatory cells leads to loss of suppressive function and development of systemic autoimmunity

(2019) Ameya S. Gokhale et al.   JOURNAL OF AUTOIMMUNITY

Ikaros Zinc Finger Transcription Factors: Regulators of Cytokine Signaling Pathways and CD4+ T Helper Cell Differentiation

(2019) Michael D. Powell et al.   Frontiers in Immunology

Terminal Effector CD8 T Cells Defined by an IKZF2+IL-7R− Transcriptional Signature Express FcγRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity

(2019) Prossy Naluyima et al.   JOURNAL OF IMMUNOLOGY

Ikaros prevents autoimmunity by controlling anergy and Toll-like receptor signaling in B cells

(2019) Tanja A. Schwickert et al.   NATURE IMMUNOLOGY

The Ikaros family in lymphocyte development

(2018) Beate Heizmann et al.   CURRENT OPINION IN IMMUNOLOGY

Human T Cell Development, Localization, and Function throughout Life

(2018) Brahma V. Kumar et al.   IMMUNITY

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

OUP accepted manuscript

(2018)   Journal of Crohns & Colitis

A Fresh View on Lymph Node Organogenesis

(2018) Lucas Onder et al.   TRENDS IN IMMUNOLOGY

Human Innate Lymphoid Cells: Their Functional and Cellular Interactions in Decidua

(2018) Paola Vacca et al.   Frontiers in Immunology

Gene Regulatory Programs Conferring Phenotypic Identities to Human NK Cells

(2018) Patrick L. Collins et al.   CELL

The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma

(2017) Katia Georgopoulos   GENES & DEVELOPMENT

The Broad Spectrum of Human Natural Killer Cell Diversity

(2017) Aharon G. Freud et al.   IMMUNITY

Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4+Th Cells

(2017) Kaitlin A. Read et al.   JOURNAL OF IMMUNOLOGY

Expression and splicing of Ikaros family members in murine and human thymocytes

(2017) Julie L. Mitchell et al.   MOLECULAR IMMUNOLOGY

T Helper Cell Differentiation, Heterogeneity, and Plasticity

(2017) Jinfang Zhu   Cold Spring Harbor Perspectives in Biology

Transcriptome analysis reveals similarities between human blood CD3− CD56bright cells and mouse CD127+ innate lymphoid cells

(2017) David S. J. Allan et al.   Scientific Reports

Ikaros limits follicular B cell activation by regulating B cell receptor signaling pathways

(2016) Beate Heizmann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

STAT4-associated natural killer cell tolerance following liver transplantation

(2016) K M Jamil et al.   GUT

MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor

(2016) Huang-Yu Yang et al.   IMMUNITY

Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway

(2016) Shiyang Li et al.   IMMUNITY

IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing

(2016) Gregory D. Rak et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA sequencing

(2016) Åsa K Björklund et al.   NATURE IMMUNOLOGY

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

Generation of Helios reporter mice and an evaluation of the suppressive capacity of Helios+regulatory T cellsin vitro

(2015) Kazunari Sugita et al.   EXPERIMENTAL DERMATOLOGY

Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+Conventional T Cells

(2015) Sadiye Amcaoglu Rieder et al.   JOURNAL OF IMMUNOLOGY

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

(2015) H.-J. Kim et al.   SCIENCE

IKAROS: a multifunctional regulator of the polymerase II transcription cycle

(2015) Stefania Bottardi et al.   TRENDS IN GENETICS

Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2

(2015) Attila Oravecz et al.   Nature Communications

Helios Enhances Treg Cell Function in Cooperation With FoxP3

(2015) Hiroaki Takatori et al.   Arthritis & Rheumatology

Peripheral natural killer cell maturation depends on the transcription factor Aiolos

(2014) M. L. Holmes et al.   EMBO JOURNAL

Human RORγt+CD34+ Cells Are Lineage-Specified Progenitors of Group 3 RORγt+ Innate Lymphoid Cells

(2014) Elisa Montaldo et al.   IMMUNITY

tTregs, pTregs, and iTregs: similarities and differences

(2014) Ethan M. Shevach et al.   IMMUNOLOGICAL REVIEWS

Ikaros fingers on lymphocyte differentiation

(2014) Toshimi Yoshida et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Cutting Edge: Ikaros Is a Regulator of Th2 Cell Differentiation

(2014) M. R. Quirion et al.   JOURNAL OF IMMUNOLOGY

Ikaros Imposes a Barrier to CD8+ T Cell Differentiation by Restricting Autocrine IL-2 Production

(2014) S. O'Brien et al.   JOURNAL OF IMMUNOLOGY

Restriction of IL-22–Producing T Cell Responses and Differential Regulation of Regulatory T Cell Compartments by Zinc Finger Transcription Factor Ikaros

(2014) Jennifer J. Heller et al.   JOURNAL OF IMMUNOLOGY

Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia

(2014) Ila Joshi et al.   NATURE IMMUNOLOGY

Stage-specific control of early B cell development by the transcription factor Ikaros

(2014) Tanja A Schwickert et al.   NATURE IMMUNOLOGY

TNF-α blockade induces IL-10 expression in human CD4+ T cells

(2014) Hayley G. Evans et al.   Nature Communications

Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation

(2013) I. Ferreiros-Vidal et al.   BLOOD

Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells

(2013) Anja Fuchs et al.   IMMUNITY

An Inherently Bifunctional Subset of Foxp3+ T Helper Cells Is Controlled by the Transcription Factor Eos

(2013) Madhav D. Sharma et al.   IMMUNITY

Ikaros Sets the Potential for Th17 Lineage Gene Expression through Effects on Chromatin State in Early T Cell Development

(2013) Larry Y. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals

(2013) Beate Heizmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Memory Helios- FOXP3+ Regulatory T Cells (Tregs) Encompass Induced Tregs That Express Aiolos and Respond to IL-1  by Downregulating Their Suppressor Functions

(2013) C. Raffin et al.   JOURNAL OF IMMUNOLOGY

Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros

(2013) Hilde Schjerven et al.   NATURE IMMUNOLOGY

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

(2013) Jochem H Bernink et al.   NATURE IMMUNOLOGY

The Ikaros Transcription Factor Regulates Responsiveness to IL-12 and Expression of IL-2 Receptor Alpha in Mature, Activated CD8 T Cells

(2013) Eric T. Clambey et al.   PLoS One

Helper T cell diversity and plasticity

(2012) Shingo Nakayamada et al.   CURRENT OPINION IN IMMUNOLOGY

Silencing of the Il2 gene transcription is regulated by epigenetic changes in anergic T cells

(2012) Sanmay Bandyopadhyay et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Loss of Epigenetic Modification Driven by the Foxp3 Transcription Factor Leads to Regulatory T Cell Insufficiency

(2012) Matthew L. Bettini et al.   IMMUNITY

Helios Induces Epigenetic Silencing of Il2 Gene Expression in Regulatory T Cells

(2012) I. Baine et al.   JOURNAL OF IMMUNOLOGY

Aiolos promotes TH17 differentiation by directly silencing Il2 expression

(2012) Francisco J Quintana et al.   NATURE IMMUNOLOGY

Tuning of Natural Killer Cell Reactivity by NKp46 and Helios Calibrates T Cell Responses

(2012) E. Narni-Mancinelli et al.   SCIENCE

IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation

(2011) Wei Liao et al.   CURRENT OPINION IN IMMUNOLOGY

The Ikaros gene family: Transcriptional regulators of hematopoiesis and immunity

(2011) Liza B. John et al.   MOLECULAR IMMUNOLOGY

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

(2011) Jenny M Mjösberg et al.   NATURE IMMUNOLOGY

Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis

(2011) Jiangwen Zhang et al.   NATURE IMMUNOLOGY

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

(2011) Jacob S Lee et al.   NATURE IMMUNOLOGY

Ikaros changes the face of NuRD remodeling

(2011) Kenneth J Oestreich et al.   NATURE IMMUNOLOGY

Helios Is Associated with CD4 T Cells Differentiating to T Helper 2 and Follicular Helper T Cells In Vivo Independently of Foxp3 Expression

(2011) Karine Serre et al.   PLoS One

Helios Expression Is a Marker of T Cell Activation and Proliferation

(2011) Tatiana Akimova et al.   PLoS One

Awakening lineage potential by Ikaros-mediated transcriptional priming

(2010) Toshimi Yoshida et al.   CURRENT OPINION IN IMMUNOLOGY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Ikaros and Aiolos Inhibit Pre-B-Cell Proliferation by Directly Suppressing c-Myc Expression

(2010) S. Ma et al.   MOLECULAR AND CELLULAR BIOLOGY

A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells

(2010) Derese Getnet et al.   MOLECULAR IMMUNOLOGY

Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell–like and Foxp3+ regulatory T cells

(2010) Roopali Gandhi et al.   NATURE IMMUNOLOGY

Lymphoid tissue inducer cells: architects of CD4 immune responses in mice and men

(2009) M.-Y. Kim et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Genome-wide Lineage-Specific Transcriptional Networks Underscore Ikaros-Dependent Lymphoid Priming in Hematopoietic Stem Cells

(2009) Samuel Yao-Ming Ng et al.   IMMUNITY

Ikaros Silences T-bet Expression and Interferon-γ Production during T Helper 2 Differentiation

(2009) Rajan M. Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ikaros controls isotype selection during immunoglobulin class switch recombination

(2009) MacLean Sellars et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ikaros Is a Regulator of Il10 Expression in CD4+ T Cells

(2009) S. E. Umetsu et al.   JOURNAL OF IMMUNOLOGY

Helios Deficiency Has Minimal Impact on T Cell Development and Function

(2009) Q. Cai et al.   JOURNAL OF IMMUNOLOGY

Eos Mediates Foxp3-Dependent Gene Silencing in CD4+ Regulatory T Cells

(2009) F. Pan et al.   SCIENCE

A mechanism for Ikaros regulation of human globin gene switching

(2008) Janelle R. Keys et al.   BRITISH JOURNAL OF HAEMATOLOGY

Recruitment of Ikaros to Pericentromeric Heterochromatin Is Regulated by Phosphorylation

(2008) Zafer Gurel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

(2008) Marina Cella et al.   NATURE

Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros

(2008) Damien Reynaud et al.   NATURE IMMUNOLOGY

Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells

(2008) Tom Cupedo et al.   NATURE IMMUNOLOGY