The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma

Superenhancer reprogramming drives a B-cell–epithelial transition and high-risk leukemia

(2016) Yeguang Hu et al.   GENES & DEVELOPMENT

Pioneering Activity of the C-Terminal Domain of EBF1 Shapes the Chromatin Landscape for B Cell Programming

(2016) Sören Boller et al.   IMMUNITY

A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

(2016) Mary E. Matyskiela et al.   NATURE

Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase

(2016) Georg Petzold et al.   NATURE

Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment

(2016) Hao Yuan Kueh et al.   NATURE IMMUNOLOGY

Transcriptional Regulation of Innate and Adaptive Lymphocyte Lineages

(2015) Maria Elena De Obaldia et al.   Annual Review of Immunology

Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia

(2015) Michelle L. Churchman et al.   CANCER CELL

Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor

(2015) Teresita L. Arenzana et al.   GENES & DEVELOPMENT

Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

(2015) Kathryn G. Roberts et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Ikaros Promoter Element with Dual Epigenetic and Transcriptional Activities

(2015) Elizabeth A. Perotti et al.   PLoS One

Transcriptional Control of Early T and B Cell Developmental Choices

(2014) Ellen V. Rothenberg   Annual Review of Immunology

Reduced Lymphoid Lineage Priming Promotes Human Hematopoietic Stem Cell Expansion

(2014) Peter van Galen et al.   Cell Stem Cell

Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia

(2014) Ila Joshi et al.   NATURE IMMUNOLOGY

Stage-specific control of early B cell development by the transcription factor Ikaros

(2014) Tanja A Schwickert et al.   NATURE IMMUNOLOGY

Promoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain

(2014) Tomoko Yamada et al.   NEURON

Lenalidomide induces degradation of IKZF1 and IKZF3

(2014) Jan Krönke et al.   OncoImmunology

Transcriptional regulation of the Ikzf1 locus

(2013) T. Yoshida et al.   BLOOD

Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN

(2013) Anita K. Gandhi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Mapping Cellular Hierarchy by Single-Cell Analysis of the Cell Surface Repertoire

(2013) Guoji Guo et al.   Cell Stem Cell

Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals

(2013) Beate Heizmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells

(2013) Robert Nechanitzky et al.   NATURE IMMUNOLOGY

Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros

(2013) Hilde Schjerven et al.   NATURE IMMUNOLOGY

Ikaros promotes early-born neuronal fates in the cerebral cortex

(2013) J. M. Alsio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

(2013) J. Kronke et al.   SCIENCE

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

(2013) G. Lu et al.   SCIENCE

Biclonal and biallelic deletions occur in 20% of B-ALL cases with IKZF1 mutations

(2012) A Dupuis et al.   LEUKEMIA

Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

(2012) Warren A. Whyte et al.   NATURE

Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate

(2012) R. Mansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenesis of Myeloma

(2011) Kenneth C. Anderson et al.   Annual Review of Pathology-Mechanisms of Disease

Pioneer transcription factors: establishing competence for gene expression

(2011) K. S. Zaret et al.   GENES & DEVELOPMENT

A critical role for TCF-1 in T-lineage specification and differentiation

(2011) Brittany Nicole Weber et al.   NATURE

Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis

(2011) Jiangwen Zhang et al.   NATURE IMMUNOLOGY

Helios Expression Is a Marker of T Cell Activation and Proliferation

(2011) Tatiana Akimova et al.   PLoS One

T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling

(2011) K. Germar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor

(2011) E. Welinder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombineering Hunchback identifies two conserved domains required to maintain neuroblast competence and specify early-born neuronal identity

(2010) K. D. Tran et al.   DEVELOPMENT

Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of Chromatin

(2010) Thomas Treiber et al.   IMMUNITY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia

(2010) C Virely et al.   LEUKEMIA

A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate

(2010) Yin C Lin et al.   NATURE IMMUNOLOGY

An Essential Developmental Checkpoint for Production of the T Cell Lineage

(2010) T. Ikawa et al.   SCIENCE

Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development

(2009) M. A. Inlay et al.   GENES & DEVELOPMENT

Genome-wide Lineage-Specific Transcriptional Networks Underscore Ikaros-Dependent Lymphoid Priming in Hematopoietic Stem Cells

(2009) Samuel Yao-Ming Ng et al.   IMMUNITY

Stepwise Activation of Enhancer and Promoter Regions of the B Cell Commitment Gene Pax5 in Early Lymphopoiesis

(2009) Thorsten Decker et al.   IMMUNITY

Ikaros Stability and Pericentromeric Localization Are Regulated by Protein Phosphatase 1

(2009) Marcela Popescu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IKZF1(Ikaros) Deletions inBCR-ABL1–Positive Acute Lymphoblastic Leukemia Are Associated With Short Disease-Free Survival and High Rate of Cumulative Incidence of Relapse: A GIMEMA AL WP Report

(2009) Giovanni Martinelli et al.   JOURNAL OF CLINICAL ONCOLOGY

Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons

(2009) Raquel Martín-Ibáñez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Helios Deficiency Has Minimal Impact on T Cell Development and Function

(2009) Q. Cai et al.   JOURNAL OF IMMUNOLOGY

Deletion ofIKZF1and Prognosis in Acute Lymphoblastic Leukemia

(2009) Charles G. Mullighan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance

(2008) I. Iacobucci et al.   BLOOD

The role of the chromatin remodeler Mi-2  in hematopoietic stem cell self-renewal and multilineage differentiation

(2008) T. Yoshida et al.   GENES & DEVELOPMENT

Identification of different Ikaros cDNA transcripts in Philadelphia-positive adult acute lymphoblastic leukemia by a high-throughput capillary electrophoresis sizing method

(2008) I. Iacobucci et al.   HAEMATOLOGICA

E2A Proteins Promote Development of Lymphoid-Primed Multipotent Progenitors

(2008) Sheila Dias et al.   IMMUNITY

Ikaros Represses the Transcriptional Response to Notch Signaling in T-Cell Development

(2008) E. Kleinmann et al.   MOLECULAR AND CELLULAR BIOLOGY

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

(2008) Charles G. Mullighan et al.   NATURE

Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5

(2008) Jagan M R Pongubala et al.   NATURE IMMUNOLOGY

Ikaros Confers Early Temporal Competence to Mouse Retinal Progenitor Cells

(2008) Jimmy Elliott et al.   NEURON