Mitochondria-targeted therapeutics, MitoQ and BGP-15, reverse aging-associated meiotic spindle defects in mouse and human oocytes

NAD+ Repletion Rescues Female Fertility during Reproductive Aging

(2020) Michael J. Bertoldo et al.   Cell Reports

The Drug Candidate BGP-15 Delays the Onset of Diastolic Dysfunction in the Goto-Kakizaki Rat Model of Diabetic Cardiomyopathy

(2019) Mariann Bombicz et al.   MOLECULES

Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging

(2019) Emre Seli et al.   FERTILITY AND STERILITY

MitoQ ameliorates testicular damage induced by gamma irradiation in rats: Modulation of mitochondrial apoptosis and steroidogenesis

(2019) Ayman A. Ibrahim et al.   LIFE SCIENCES

The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice

(2019) Melissa L. Young et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mitochondria-targeted therapy rescues development and quality of embryos derived from oocytes matured under oxidative stress conditions: a bovine in vitro model

(2019) Waleed F A Marei et al.   HUMAN REPRODUCTION

Mechanisms of kinetochore-microtubule attachment errors in mammalian oocytes

(2018) Tomoya S. Kitajima   DEVELOPMENT GROWTH & DIFFERENTIATION

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older AdultsNovelty and Significance

(2018) Matthew J. Rossman et al.   HYPERTENSION

BGP-15 improves contractile function of regenerating soleus muscle

(2018) Tábata L. Nascimento et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Alterations in oocyte mitochondrial number and function are related to spindle defects and occur with maternal aging in mice and humans†

(2018) Rolando Pasquariello et al.   BIOLOGY OF REPRODUCTION

Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errors

(2017) Jessica Greaney et al.   HUMAN REPRODUCTION UPDATE

BGP-15 prevents the death of neurons in a mouse model of familial dysautonomia

(2017) Sarah B. Ohlen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II

(2017) Ibtissem Nabti et al.   Nature Communications

BGP-15 Protects against Oxidative Stress- or Lipopolysaccharide-Induced Mitochondrial Destabilization and Reduces Mitochondrial Production of Reactive Oxygen Species

(2017) Katalin Sumegi et al.   PLoS One

The lipid peroxidation product 4-hydroxynonenal contributes to oxidative stress-mediated deterioration of the ageing oocyte

(2017) Bettina P. Mihalas et al.   Scientific Reports

Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes

(2017) Micheal S. Ward et al.   Scientific Reports

Understanding and preventing mitochondrial oxidative damage

(2016) Michael P. Murphy   BIOCHEMICAL SOCIETY TRANSACTIONS

Obesity-induced oocyte mitochondrial defects are partially prevented and rescued by supplementation with co-enzyme Q10 in a mouse model

(2016) C.E. Boots et al.   HUMAN REPRODUCTION

Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and mtDNA quantity

(2016) Elnur Babayev et al.   MATURITAS

Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging

(2015) Assaf Ben-Meir et al.   AGING CELL

How oocytes try to get it right: spindle checkpoint control in meiosis

(2015) Sandra A. Touati et al.   CHROMOSOMA

Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors

(2015) L. L. Wu et al.   DEVELOPMENT

Mitochondria-targeted antioxidants

(2015) Anne O. Oyewole et al.   FASEB JOURNAL

Reproduction at an advanced maternal age and maternal health

(2015) Mark V. Sauer   FERTILITY AND STERILITY

Centrosome and microtubule functions and dysfunctions in meiosis: implications for age-related infertility and developmental disorders

(2015) Heide Schatten et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes

(2015) Z. Holubcova et al.   SCIENCE

DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age

(2015) Petros Marangos et al.   Nature Communications

Non-canonical function of spindle assembly checkpoint proteins after APC activation reduces aneuploidy in mouse oocytes

(2014) Simon I.R. Lane et al.   Nature Communications

Molecular causes of aneuploidy in mammalian eggs

(2013) K. T. Jones et al.   DEVELOPMENT

Resveratrol protects against age-associated infertility in mice

(2013) Mengyuan Liu et al.   HUMAN REPRODUCTION

Measurement of ATP in Single Oocytes: Impact of Maturation and Cumulus Cells on Levels and Consumption

(2013) Caroline M. Dalton et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Maternal obesity, infertility and mitochondrial dysfunction: potential mechanisms emerging from mouse model systems

(2013) N. M. Grindler et al.   MOLECULAR HUMAN REPRODUCTION

Delay in oocyte aging in mice by the antioxidant N-acetyl-l-cysteine (NAC)

(2012) Jinmiao Liu et al.   HUMAN REPRODUCTION

Hsp72 preserves muscle function and slows progression of severe muscular dystrophy

(2012) Stefan M. Gehrig et al.   NATURE

Human aneuploidy: mechanisms and new insights into an age-old problem

(2012) So I. Nagaoka et al.   NATURE REVIEWS GENETICS

Donor age is a major determinant of success of oocyte donation/recipient programme

(2011) Y. A. Wang et al.   HUMAN REPRODUCTION

Evidence that Weakened Centromere Cohesion Is a Leading Cause of Age-Related Aneuploidy in Oocytes

(2010) Teresa Chiang et al.   CURRENT BIOLOGY

Age-Related Meiotic Segregation Errors in Mammalian Oocytes Are Preceded by Depletion of Cohesin and Sgo2

(2010) Lisa Martine Lister et al.   CURRENT BIOLOGY

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

(2010) Edward J. Gane et al.   LIVER INTERNATIONAL

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

(2010) Barry J. Snow et al.   MOVEMENT DISORDERS

The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients

(2009) Yaakov Bentov et al.   FERTILITY AND STERILITY

The cell cycle is a redox cycle: Linking phase-specific targets to cell fate

(2009) William C. Burhans et al.   FREE RADICAL BIOLOGY AND MEDICINE

Improvement of Insulin Sensitivity by a Novel Drug, BGP-15, in Insulin-resistant Patients: A Proof of Concept Randomized Double-blind Clinical Trial

(2009) B. Literáti-Nagy et al.   HORMONE AND METABOLIC RESEARCH