Human aneuploidy: mechanisms and new insights into an age-old problem

ACOG Committee Opinion No. 430: Preimplantation Genetic Screening for Aneuploidy

(2014)   OBSTETRICS AND GYNECOLOGY

Spindle assembly checkpoint signalling is uncoupled from chromosomal position in mouse oocytes

(2012) L. Gui et al.   DEVELOPMENT

Timing of anaphase-promoting complex activation in mouse oocytes is predicted by microtubule-kinetochore attachment but not by bivalent alignment or tension

(2012) S. I. R. Lane et al.   DEVELOPMENT

Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women

(2012) Yvonne A R White et al.   NATURE MEDICINE

Meiotic Origins of Maternal Age-Related Aneuploidy1

(2011) Teresa Chiang et al.   BIOLOGY OF REPRODUCTION

Genetically enhanced asynapsis of autosomal chromatin promotes transcriptional dysregulation and meiotic failure

(2011) David Homolka et al.   CHROMOSOMA

Oocyte-Specific Differences in Cell-Cycle Control Create an Innate Susceptibility to Meiotic Errors

(2011) So Iha Nagaoka et al.   CURRENT BIOLOGY

Whole-Chromosome Aneuploidy Analysis in Human Oocytes: Focus on Comparative Genomic Hybridization

(2011) A. Obradors et al.   CYTOGENETIC AND GENOME RESEARCH

Aneuploidy in Human Spermatozoa

(2011) C. Templado et al.   CYTOGENETIC AND GENOME RESEARCH

The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility

(2011) Yurema Herrán et al.   EMBO JOURNAL

Bisphenol A exposure reduces the estradiol response to gonadotropin stimulation during in vitro fertilization

(2011) Michael S. Bloom et al.   FERTILITY AND STERILITY

Embryonic imprinting perturbations do not originate from superovulation-induced defects in DNA methylation acquisition

(2011) Michelle M. Denomme et al.   FERTILITY AND STERILITY

Successful preimplantation genetic aneuploidy screening in Turkish patients

(2011) N. Ercelen et al.   GENETICS AND MOLECULAR RESEARCH

Human meiotic progression and recombination are affected by Bisphenol A exposure during in vitro human oocyte development

(2011) M.A. Brieño-Enríquez et al.   HUMAN REPRODUCTION

Polar body array CGH for prediction of the status of the corresponding oocyte. Part I: clinical results

(2011) J. Geraedts et al.   HUMAN REPRODUCTION

Array comparative genomic hybridisation on first polar bodies suggests that non-disjunction is not the predominant mechanism leading to aneuploidy in humans

(2011) A. S. Gabriel et al.   JOURNAL OF MEDICAL GENETICS

The cytogenetics of polar bodies: insights into female meiosis and the diagnosis of aneuploidy

(2011) E. Fragouli et al.   MOLECULAR HUMAN REPRODUCTION

Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies

(2011) K. Selesniemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PGD and aneuploidy screening for 24 chromosomes by genome-wide SNP analysis: seeing the wood and the trees

(2011) Alan H. Handyside   REPRODUCTIVE BIOMEDICINE ONLINE

Evidence that Weakened Centromere Cohesion Is a Leading Cause of Age-Related Aneuploidy in Oocytes

(2010) Teresa Chiang et al.   CURRENT BIOLOGY

Oocyte Cohesin Expression Restricted to Predictyate Stages Provides Full Fertility and Prevents Aneuploidy

(2010) Ekaterina Revenkova et al.   CURRENT BIOLOGY

Age-Related Meiotic Segregation Errors in Mammalian Oocytes Are Preceded by Depletion of Cohesin and Sgo2

(2010) Lisa Martine Lister et al.   CURRENT BIOLOGY

Female Meiosis: Coming Unglued with Age

(2010) Patricia Hunt et al.   CURRENT BIOLOGY

Meiotic sex chromosome inactivation

(2010) Jeffrey M. Cloutier et al.   CURRENT BIOLOGY

Evidence that Meiotic Sex Chromosome Inactivation Is Essential for Male Fertility

(2010) Hélène Royo et al.   CURRENT BIOLOGY

Single nucleotide polymorphism microarray–based concurrent screening of 24-chromosome aneuploidy and unbalanced translocations in preimplantation human embryos

(2010) Nathan R. Treff et al.   FERTILITY AND STERILITY

Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos

(2010) Cristina Gutiérrez-Mateo et al.   FERTILITY AND STERILITY

Serum unconjugated bisphenol A concentrations in women may adversely influence oocyte quality during in vitro fertilization

(2010) Victor Y. Fujimoto et al.   FERTILITY AND STERILITY

Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes

(2010) K. Tachibana-Konwalski et al.   GENES & DEVELOPMENT

Dynamics of cohesin proteins REC8, STAG3, SMC1  and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes

(2010) R. Garcia-Cruz et al.   HUMAN REPRODUCTION

Prospective cohort study in high responder oocyte donors using two hormonal stimulation protocols: impact on embryo aneuploidy and development

(2010) C. Rubio et al.   HUMAN REPRODUCTION

SNP microarray-based 24 chromosome aneuploidy screening is significantly more consistent than FISH

(2010) N. R. Treff et al.   MOLECULAR HUMAN REPRODUCTION

Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities

(2010) P. Allard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective cohesin is associated with age-dependent misaligned chromosomes in oocytes

(2010) Lin Liu et al.   REPRODUCTIVE BIOMEDICINE ONLINE

PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice

(2010) F. Baudat et al.   SCIENCE

Bisphenol A Impairs Follicle Growth, Inhibits Steroidogenesis, and Downregulates Rate-Limiting Enzymes in the Estradiol Biosynthesis Pathway

(2010) Jackye Peretz et al.   TOXICOLOGICAL SCIENCES

Cdc20 Is Critical for Meiosis I and Fertility of Female Mice

(2010) Fang Jin et al.   PLoS Genetics

Regulation of APC/C Activity in Oocytes by a Bub1-Dependent Spindle Assembly Checkpoint

(2009) Barry E. McGuinness et al.   CURRENT BIOLOGY

Technology requirements for preimplantation genetic diagnosis to improve assisted reproduction outcomes

(2009) Santiago Munné et al.   FERTILITY AND STERILITY

Transplantation directs oocyte maturation from embryonic stem cells and provides a therapeutic strategy for female infertility

(2009) Cory R. Nicholas et al.   HUMAN MOLECULAR GENETICS

Dual effects of superovulation: loss of maternal and paternal imprinted methylation in a dose-dependent manner

(2009) Brenna A. Market-Velker et al.   HUMAN MOLECULAR GENETICS

In vitro post-meiotic germ cell development from human embryonic stem cells

(2009) B. Aflatoonian et al.   HUMAN REPRODUCTION

Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation

(2009) Kehkooi Kee et al.   NATURE

The consequences of asynapsis for mammalian meiosis

(2009) Paul S. Burgoyne et al.   NATURE REVIEWS GENETICS

A Spindle Assembly Checkpoint Protein Functions in Prophase I Arrest and Prometaphase Progression

(2009) H. Homer et al.   SCIENCE

Meiotic Recombination in Human Oocytes

(2009) Edith Y. Cheng et al.   PLoS Genetics

Comprehensive molecular cytogenetic analysis of the human blastocyst stage

(2008) E. Fragouli et al.   HUMAN REPRODUCTION

Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation

(2008) Shantha K. Mahadevaiah et al.   JOURNAL OF CELL BIOLOGY

Evaluation of aneugenic effects of bisphenol A in somatic and germ cells of the mouse

(2008) F. Pacchierotti et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Sequence Variants in the RNF212 Gene Associate with Genome-Wide Recombination Rate

(2008) A. Kong et al.   SCIENCE

New Insights into Human Nondisjunction of Chromosome 21 in Oocytes

(2008) Tiffany Renee Oliver et al.   PLoS Genetics

Exposure of mouse oocytes to bisphenol A causes meiotic arrest but not aneuploidy

(2007) Ursula Eichenlaub-Ritter et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Continuous exposure to bisphenol A during in vitro follicular development induces meiotic abnormalities

(2007) Sandy Lenie et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS