Beyond energy storage: roles of glycogen metabolism in health and disease

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase

(2020) Erika M. Palmieri et al.   Nature Communications

Glycogen metabolism regulates macrophage-mediated acute inflammatory responses

(2020) Jingwei Ma et al.   Nature Communications

The Roles of CD8+ T Cell Subsets in Antitumor Immunity

(2020) Michael St. Paul et al.   TRENDS IN CELL BIOLOGY

Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma

(2020) Yunfeng Gao et al.   Nature Biomedical Engineering

Unraveling the Regulation of Hepatic Gluconeogenesis

(2019) Xueping Zhang et al.   Frontiers in Endocrinology

The Central Role of Glucokinase in Glucose Homeostasis: A Perspective 50 Years After Demonstrating the Presence of the Enzyme in Islets of Langerhans

(2019) Franz M. Matschinsky et al.   Frontiers in Physiology

The Metabolic Signature of Macrophage Responses

(2019) Antonella Viola et al.   Frontiers in Immunology

Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells

(2019) Ke Tang et al.   ONCOGENE

Is liver glycogen fragility a possible drug target for diabetes?

(2019) Cheng Li et al.   FASEB JOURNAL

The Role of Brain Glycogen in Supporting Physiological Function

(2019) Laura R. Rich et al.   Frontiers in Neuroscience

Single-Cell Analysis for Glycogen Localization and Metabolism in Cultured Astrocytes

(2019) Yuanyuan Zhu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T-cell memory development

(2019) Huafeng Zhang et al.   NATURE CELL BIOLOGY

Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway

(2019) David Kung-Chun Chiu et al.   Cell Death & Disease

Fibrin Stiffness Mediates Dormancy of Tumor-Repopulating Cells via a Cdc42-Driven Tet2 Epigenetic Program

(2018) Yuying Liu et al.   CANCER RESEARCH

Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation

(2018) Brenda Raud et al.   Cell Metabolism

The Science and Translation of Lactate Shuttle Theory

(2018) George A. Brooks   Cell Metabolism

Managing the sugar factory: A new feather in the cap for nuclear factor Y

(2018) Sabyasachi Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dynamic life of the glycogen granule

(2018) Clara Prats et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT3/p53 pathway activation disrupts IFN-β–induced dormancy in tumor-repopulating cells

(2018) Yuying Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells

(2017) Ruihua Ma et al.   NATURE CELL BIOLOGY

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells

(2017) Yuying Liu et al.   Nature Communications

Mitochondrial composition and function under the control of hypoxia

(2017) Dominik C. Fuhrmann et al.   Redox Biology

Liver glycogen metabolism during and after prolonged endurance-type exercise

(2016) Javier T. Gonzalez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

UDP-glucose promotes neutrophil recruitment in the lung

(2016) Juliana I. Sesma et al.   Purinergic Signalling

Macrophages: Development and Tissue Specialization

(2015) Chen Varol et al.   Annual Review of Immunology

Glycogen availability and skeletal muscle adaptations with endurance and resistance exercise

(2015) Pim Knuiman et al.   Nutrition & Metabolism

Time and Demand are Two Critical Dimensions of Immunometabolism: The Process of Macrophage Activation and the Pentose Phosphate Pathway

(2015) Csörsz Nagy et al.   Frontiers in Immunology

A genetic perspective on glucose consumption in the cerebral cortex during human development

(2014) J. Caravas et al.   DIABETES OBESITY & METABOLISM

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

(2014) David O’Sullivan et al.   IMMUNITY

Extracellular UDP-Glucose Activates P2Y14Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705Phosphorylation and Binding to Hyaluronan Synthase 2 (HAS2) Promoter, Stimulating Hyaluronan Synthesis of Keratinocytes

(2014) Tiina A. Jokela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells

(2014) Caroline A. Lewis et al.   MOLECULAR CELL

Red blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging

(2014) Joy G. Mohanty et al.   Frontiers in Physiology

Carbon Monoxide Signaling in Human Red Blood Cells: Evidence for Pentose Phosphate Pathway Activation and Protein Deglutathionylation

(2013) Alessio Metere et al.   ANTIOXIDANTS & REDOX SIGNALING

AMPK: A metabolic switch for CD8+T-cell memory

(2013) Koichi Araki et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

AMPKα1: A glucose sensor that controls CD8 T-cell memory

(2013) Julia Rolf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling

(2013) Lucas B. Sullivan et al.   MOLECULAR CELL

The UDP-sugar-sensing P2Y14 receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils

(2012) Juliana I. Sesma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Dynamic Reorganization of Metabolic Enzymes into Intracellular Bodies

(2012) Jeremy D. O'Connell et al.   Annual Review of Cell and Developmental Biology

Memory T Cell Subsets, Migration Patterns, and Tissue Residence

(2012) Scott N. Mueller et al.   Annual Review of Immunology

Glycogen and its metabolism: some new developments and old themes

(2012) Peter J. Roach et al.   BIOCHEMICAL JOURNAL

Compartmentation of glycogen metabolism revealed from 13C isotopologue distributions

(2012) Igor Marin de Mas et al.   BMC Systems Biology

Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells

(2012) Elena Favaro et al.   Cell Metabolism

Regulation of glycogen synthase from mammalian skeletal muscle - a unifying view of allosteric and covalent regulation

(2012) Daniel C. Palm et al.   FEBS Journal

The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate

(2012) Chiara Riganti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Soft fibrin gels promote selection and growth of tumorigenic cells

(2012) Jing Liu et al.   NATURE MATERIALS

Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival

(2012) Joffrey Pelletier et al.   Frontiers in Oncology

Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle

(2011) M. H. Vendelbo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Purinergic Receptors Influence the Differentiation of Human Mesenchymal Stem Cells

(2011) Nina Zippel et al.   STEM CELLS AND DEVELOPMENT

Hypoxia. 2. Hypoxia regulates cellular metabolism

(2010) William W. Wheaton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Allosteric Regulation of Glycogen Synthase Controls Glycogen Synthesis in Muscle

(2010) Michale Bouskila et al.   Cell Metabolism

Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia

(2010) Guo-Min Shen et al.   FEBS LETTERS

Hypoxia Promotes Glycogen Accumulation through Hypoxia Inducible Factor (HIF)-Mediated Induction of Glycogen Synthase 1

(2010) Nuria Pescador et al.   PLoS One

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

UDP-glucose acting at P2Y 14 receptors is a mediator of mast cell degranulation

(2009) Zhan-Guo Gao et al.   BIOCHEMICAL PHARMACOLOGY

Dual Regulation of Muscle Glycogen Synthase during Exercise by Activation and Compartmentalization

(2009) Clara Prats et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

(2009) David R. Mole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum/Golgi Nucleotide Sugar Transporters Contribute to the Cellular Release of UDP-sugar Signaling Molecules

(2009) Juliana I. Sesma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Four grams of glucose

(2008) David H. Wasserman   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM