Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2016–2020)

Liposomal formulation of HIF-1α inhibitor echinomycin eliminates established metastases of triple-negative breast cancer

(2020) Christopher M. Bailey et al.   Nanomedicine-Nanotechnology Biology and Medicine

Disturbed Flow Increases UBE2C (Ubiquitin E2 Ligase C) via Loss of miR-483-3p, Inducing Aortic Valve Calcification by the HIF-1α (Hypoxia-Inducible Factor-1α) Pathway in Endothelial Cells

(2019) Joan Fernandez Esmerats et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Berberine and barberry (Berberis vulgaris ): A clinical review

(2019) Mohsen Imenshahidi et al.   PHYTOTHERAPY RESEARCH

HIF Inhibitors: Status of Current Clinical Development

(2019) Jaleh Fallah et al.   Current Oncology Reports

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

(2019) Strowitzki et al.   Cells

3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma

(2019) Rui Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allosteric inhibition of HIF-2α as a novel therapy for clear cell renal cell carcinoma

(2019) Yancheng Yu et al.   DRUG DISCOVERY TODAY

Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges

(2019) Muhammad Zaeem Noman et al.   Cells

Mechanisms of ischaemic neural progenitor proliferation: a regulatory role of the HIF‐1α‐CBX7 pathway

(2019) H.‐Y. Chiu et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration

(2018) Liwei Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma

(2018) Kevin D. Courtney et al.   JOURNAL OF CLINICAL ONCOLOGY

Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy

(2018) Hongchan An et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)

(2018) Paul M. Wehn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit

(2017) Matthew G. Costales et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The novel hypoxia-inducible factor-1α inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth

(2017) Hyun Seung Ban et al.   Cell Death & Disease

Identification of Targets of the HIF-1 Inhibitor IDF-11774 Using Alkyne-Conjugated Photoaffinity Probes

(2016) Hyun Seung Ban et al.   BIOCONJUGATE CHEMISTRY

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

(2016) Eli M. Wallace et al.   CANCER RESEARCH

Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015)

(2016) Hyun Seung Ban et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Heat Shock Proteins Promote Cancer: It's a Protection Racket

(2016) Stuart K. Calderwood et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular and functional evaluation of a novel HIF inhibitor, benzopyranyl 1,2,3-triazole compound

(2016) Kyunghye Park et al.   Oncotarget

Total synthesis of (−)-deguelin via an iterative pyran-ring formation strategy

(2015) Seungbeom Lee et al.   CHEMICAL COMMUNICATIONS

Structural Elucidation and Synthesis of Eudistidine A: An Unusual Polycyclic Marine Alkaloid that Blocks Interaction of the Protein Binding Domains of p300 and HIF-1α

(2015) Susanna T. S. Chan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii

(2015) Chenrui Li et al.   LIFE SCIENCES

The role of hypoxia-inducible factor-2 in digestive system cancers

(2015) J Zhao et al.   Cell Death & Disease

Hypoxia-Inducible Factors Link Iron Homeostasis and Erythropoiesis

(2014) Yatrik M. Shah et al.   GASTROENTEROLOGY

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth

(2013) Noel A Warfel et al.   CELL CYCLE

Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors

(2013) Hidemitsu Minegishi et al.   ACS Medicinal Chemistry Letters

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage

(2012) F. Relaix et al.   DEVELOPMENT

Design, Synthesis, and Biological Evaluation of Novel Deguelin-Based Heat Shock Protein 90 (HSP90) Inhibitors Targeting Proliferation and Angiogenesis

(2012) Dong-Jo Chang et al.   JOURNAL OF MEDICINAL CHEMISTRY

HIF-1 versus HIF-2 — Is one more important than the other?

(2012) Agnieszka Loboda et al.   VASCULAR PHARMACOLOGY

Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

(2010) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

(2009) Yatrik M. Shah et al.   Cell Metabolism