LSD1/KDM1A, a Gate-Keeper of Cancer Stemness and a Promising Therapeutic Target
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Title
LSD1/KDM1A, a Gate-Keeper of Cancer Stemness and a Promising Therapeutic Target
Authors
Keywords
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Journal
Cancers
Volume 11, Issue 12, Pages 1821
Publisher
MDPI AG
Online
2019-11-21
DOI
10.3390/cancers11121821
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Note: Only part of the references are listed.- Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer
- (2019) Helai P. Mohammad et al. NATURE MEDICINE
- Stabilized peptide HDAC inhibitors derived from HDAC1 substrate H3K56 for the treatment of cancer stem-like cells in vivo
- (2019) Dongyuan Wang et al. CANCER RESEARCH
- CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML
- (2019) Michael E. Vinyard et al. Nature Chemical Biology
- Intratumoral Heterogeneity: More Than Just Mutations
- (2019) Kunihiko Hinohara et al. TRENDS IN CELL BIOLOGY
- Distinct Roles of the NAD+-Sirt1 and FAD-LSD1 Pathways in Metabolic Response and Tissue Development
- (2019) Mitsuyoshi Nakao et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Histone deacetylases as an epigenetic pillar for the development of hybrid inhibitors in cancer
- (2019) Giulia Stazi et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- MiR-137 knockdown promotes the osteogenic differentiation of human adipose-derived stem cells via the LSD1/BMP2/SMAD4 signaling network
- (2019) Xiaohan Ma et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy
- (2019) Antonio Romo-Morales et al. PEDIATRIC BLOOD & CANCER
- Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications
- (2019) Esperanza R. Matarredona et al. Frontiers in Oncology
- Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG
- (2019) Jamie N. Anastas et al. CANCER CELL
- The Histone Demethylase LSD1/ΚDM1A Mediates Chemoresistance in Breast Cancer via Regulation of a Stem Cell Program
- (2019) John Verigos et al. Cancers
- NGL viewer: web-based molecular graphics for large complexes
- (2018) Alexander S Rose et al. BIOINFORMATICS
- New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells
- (2018) Nam Hoang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML
- (2018) Monica Cusan et al. BLOOD
- ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia
- (2018) Tamara Maes et al. CANCER CELL
- New aspects of glioblastoma multiforme revealed by similarities between neural and glioblastoma stem cells
- (2018) Yoichiro Kawamura et al. CELL BIOLOGY AND TOXICOLOGY
- IMMU-19. LSD1 MODULATES NK CELL IMMUNOTHERAPY THROUGH AN ONCO-IMMUNOGENIC GENE SIGNATURE IN DIPG
- (2018) Cavan Bailey et al. NEURO-ONCOLOGY
- The histone demethylase LSD1 regulates inner ear progenitor differentiation through interactions with Pax2 and the NuRD repressor complex
- (2018) Dharmeshkumar Patel et al. PLoS One
- KDM1A microenvironment, its oncogenic potential, and therapeutic significance
- (2018) Tayaba Ismail et al. Epigenetics & Chromatin
- Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
- (2018) Jay H. Kalin et al. Nature Communications
- Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
- (2018) Milica Tosic et al. Nature Communications
- LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer
- (2018) T. Boulding et al. Scientific Reports
- Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia
- (2018) Alba Maiques-Diaz et al. Cell Reports
- Far Upstream Element-Binding Protein 1 Regulates LSD1 Alternative Splicing to Promote Terminal Differentiation of Neural Progenitors
- (2018) Inah Hwang et al. Stem Cell Reports
- Lysine-Specific Demethylase 1A as a Promising Target in Acute Myeloid Leukemia
- (2018) Daniela Magliulo et al. Frontiers in Oncology
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Pharmacological Inhibition of LSD1 for Cancer Treatment
- (2018) Guan-Jun Yang et al. MOLECULES
- Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment
- (2017) Ying-Chao Duan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- EZH2 or HDAC1 Inhibition Reverses Multiple Myeloma–Induced Epigenetic Suppression of Osteoblast Differentiation
- (2017) Juraj Adamik et al. MOLECULAR CANCER RESEARCH
- Marked for death: targeting epigenetic changes in cancer
- (2017) Sophia Xiao Pfister et al. NATURE REVIEWS DRUG DISCOVERY
- LSD1 demethylates HIF1α to inhibit hydroxylation and ubiquitin-mediated degradation in tumor angiogenesis
- (2017) J-Y Lee et al. ONCOGENE
- KDM1A/LSD1 regulates the differentiation and maintenance of spermatogonia in mice
- (2017) Dexter A. Myrick et al. PLoS One
- Epigenetic plasticity and the hallmarks of cancer
- (2017) William A. Flavahan et al. SCIENCE
- NeuroLSD1: Splicing-Generated Epigenetic Enhancer of Neuroplasticity
- (2017) Francesco Rusconi et al. TRENDS IN NEUROSCIENCES
- Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy
- (2017) Germana Castelli et al. OncoTargets and Therapy
- CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis
- (2017) Min Jun Jang et al. Cell Death & Disease
- A comprehensive review of lysine-specific demethylase 1 and its roles in cancer
- (2017) Amir Hosseini et al. Epigenomics
- Stable H3 peptide was delivered by gold nanorods to inhibit LSD1 activation and induce human mesenchymal stem cells differentiation
- (2017) Xin Meng et al. Oncotarget
- LSD1 Controls Timely MyoD Expression via MyoD Core Enhancer Transcription
- (2017) Isabella Scionti et al. Cell Reports
- The role of the SWI/SNF chromatin remodeling complex in maintaining the stemness of glioma initiating cells
- (2017) Hiroaki Hiramatsu et al. Scientific Reports
- Cancer Stem Cells: Basic Concepts and Therapeutic Implications
- (2016) Dany Nassar et al. Annual Review of Pathology-Mechanisms of Disease
- Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer
- (2016) Jingxin Feng et al. BREAST CANCER RESEARCH AND TREATMENT
- Intratumoral Heterogeneity of the Epigenome
- (2016) Tali Mazor et al. CANCER CELL
- The chromatin modifying complex CoREST/LSD1 negatively regulates notch pathway during cerebral cortex development
- (2016) Cecilia I. Lopez et al. Developmental Neurobiology
- Lysine-specific histone demethylases in normal and malignant hematopoiesis
- (2016) Jaclyn Andricovich et al. EXPERIMENTAL HEMATOLOGY
- LSD1 inhibitors: a patent review (2010-2015)
- (2016) Giulia Stazi et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells
- (2016) Yoshinori Ishikawa et al. MOLECULAR CANCER THERAPEUTICS
- MiR-137: an important player in neural development and neoplastic transformation
- (2016) E Mahmoudi et al. MOLECULAR PSYCHIATRY
- Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22
- (2016) Aidong Zhou et al. NATURE CELL BIOLOGY
- Targeting the cancer epigenome for therapy
- (2016) Peter A. Jones et al. NATURE REVIEWS GENETICS
- The molecular hallmarks of epigenetic control
- (2016) C. David Allis et al. NATURE REVIEWS GENETICS
- Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response pathway
- (2016) G R Sareddy et al. ONCOGENE
- LSD1 Mediates Neuronal Differentiation of Human Fetal Neural Stem Cells by Controlling the Expression of a Novel Target Gene, HEYL
- (2016) Kazumi Hirano et al. STEM CELLS
- Epigenetic Determinants of Cancer
- (2016) Stephen B. Baylin et al. Cold Spring Harbor Perspectives in Biology
- LSD1: biologic roles and therapeutic targeting
- (2016) Alba Maiques-Diaz et al. Epigenomics
- LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain
- (2016) Yixuan Wang et al. Nature Communications
- Overexpression of the shortest isoform of histone demethylase LSD1 primes hematopoietic stem cells for malignant transformation
- (2015) T. Wada et al. BLOOD
- A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC
- (2015) Helai P. Mohammad et al. CANCER CELL
- Histone demethylases in chromatin biology and beyond
- (2015) E. Dimitrova et al. EMBO REPORTS
- UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1
- (2015) H.-J. Choi et al. EMBO REPORTS
- The histone demethylase KDM1A is essential for the maintenance and differentiation of spermatogonial stem cells and progenitors
- (2015) Romain Lambrot et al. FASEB JOURNAL
- A Specific LSD1/KDM1A Isoform Regulates Neuronal Differentiation through H3K9 Demethylation
- (2015) Benoit Laurent et al. MOLECULAR CELL
- LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor
- (2015) Evgenya Y. Popova et al. MOLECULAR NEUROBIOLOGY
- GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1
- (2015) Roshana Thambyrajah et al. NATURE CELL BIOLOGY
- LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control
- (2015) Jianxun Wang et al. NATURE NEUROSCIENCE
- Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma
- (2015) Melissa M. Singh et al. NEURO-ONCOLOGY
- Lysine-specific demethylase 1 promotes the stemness and chemoresistance of Lgr5+ liver cancer initiating cells by suppressing negative regulators of β-catenin signaling
- (2015) Z-J Lei et al. ONCOGENE
- LSD1 Overexpression Is Associated with Poor Prognosis in Basal-Like Breast Cancer, and Sensitivity to PARP Inhibition
- (2015) Satoi Nagasawa et al. PLoS One
- The Nature of Embryonic Stem Cells
- (2014) Graziano Martello et al. Annual Review of Cell and Developmental Biology
- Targeting histone lysine demethylases — Progress, challenges, and the future
- (2014) Cyrille C. Thinnes et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- The epigenetic promotion of osteogenic differentiation of human adipose-derived stem cells by the genetic and chemical blockade of histone demethylase LSD1
- (2014) Wenshu Ge et al. BIOMATERIALS
- Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma
- (2014) Emily R Theisen et al. BMC CANCER
- Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
- (2014) Mario L. Suvà et al. CELL
- Evolution of the Cancer Stem Cell Model
- (2014) Antonija Kreso et al. Cell Stem Cell
- CBB1003, a lysine-specific demethylase 1 inhibitor, suppresses colorectal cancer cells growth through down-regulation of leucine-rich repeat-containing G-protein-coupled receptor 5 expression
- (2014) Hung-Chih Hsu et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Destabilizing LSD1 by Jade-2 Promotes Neurogenesis: An Antibraking System in Neural Development
- (2014) Xiao Han et al. MOLECULAR CELL
- Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance
- (2014) Hariharan Easwaran et al. MOLECULAR CELL
- Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
- (2014) S. C. Mack et al. NATURE
- Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance
- (2014) Feng Zhang et al. Nature Communications
- Suppression of Invasion and Metastasis of Triple-Negative Breast Cancer Lines by Pharmacological or Genetic Inhibition of Slug Activity
- (2014) Giovanna Ferrari-Amorotti et al. NEOPLASIA
- The histone LSD1 demethylase in stemness and cancer transcription programs
- (2013) Stefano Amente et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2
- (2013) Emanuela Toffolo et al. JOURNAL OF NEUROCHEMISTRY
- Histone lysine demethylases as targets for anticancer therapy
- (2013) Jonas W. Højfeldt et al. NATURE REVIEWS DRUG DISCOVERY
- Pluripotent Stem Cell Protein Sox2 Confers Sensitivity to LSD1 Inhibition in Cancer Cells
- (2013) Xiaoming Zhang et al. Cell Reports
- The Deubiquitinase USP28 Stabilizes LSD1 and Confers Stem-Cell-like Traits to Breast Cancer Cells
- (2013) Yadi Wu et al. Cell Reports
- Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation
- (2013) Marc A Kerenyi et al. eLife
- The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells
- (2012) William J. Harris et al. CANCER CELL
- Global expression profiling of globose basal cells and neurogenic progression within the olfactory epithelium
- (2012) Richard C. Krolewski et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation
- (2012) A Sprüssel et al. LEUKEMIA
- Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
- (2012) Tino Schenk et al. NATURE MEDICINE
- Histone methylation: a dynamic mark in health, disease and inheritance
- (2012) Eric L. Greer et al. NATURE REVIEWS GENETICS
- Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression
- (2012) Z.-Q. Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties
- (2011) J. Wang et al. CANCER RESEARCH
- CoREST/LSD1 Control the Development of Pyramidal Cortical Neurons
- (2011) Patricio Fuentes et al. CEREBRAL CORTEX
- LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells
- (2011) Antonio Adamo et al. NATURE CELL BIOLOGY
- The cancer stem cell: premises, promises and challenges
- (2011) Hans Clevers NATURE MEDICINE
- Concise Review: Induced Pluripotent Stem Cells Versus Embryonic Stem Cells: Close Enough or Yet Too Far Apart?
- (2011) Josipa Bilic et al. STEM CELLS
- miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells
- (2011) GuoQiang Sun et al. Nature Communications
- Demethylation of RB Regulator MYPT1 by Histone Demethylase LSD1 Promotes Cell Cycle Progression in Cancer Cells
- (2010) H.-S. Cho et al. CANCER RESEARCH
- The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1
- (2010) Yiwei Lin et al. EMBO JOURNAL
- Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers
- (2010) Shinya Hayami et al. INTERNATIONAL JOURNAL OF CANCER
- Histone Demethylase LSD1 Regulates Adipogenesis
- (2010) Melina M. Musri et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Alternative Splicing of the Histone Demethylase LSD1/KDM1 Contributes to the Modulation of Neurite Morphogenesis in the Mammalian Nervous System
- (2010) C. Zibetti et al. JOURNAL OF NEUROSCIENCE
- Histone Demethylase LSD1 Regulates Neural Stem Cell Proliferation
- (2010) G. Sun et al. MOLECULAR AND CELLULAR BIOLOGY
- Lysine Methylation Regulates E2F1-Induced Cell Death
- (2010) Haroula Kontaki et al. MOLECULAR CELL
- Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes
- (2010) J. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy
- (2009) J. H. Schulte et al. CANCER RESEARCH
- The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage
- (2009) Christophe Lancrin et al. NATURE
- The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
- (2008) Jing Wang et al. NATURE GENETICS
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