Article
Biochemistry & Molecular Biology
Tetsushi Kataura, Elsje G. Otten, Yoana Rabanal-Ruiz, Elias Adriaenssens, Francesca Urselli, Filippo Scialo, Lanyu Fan, Graham R. Smith, William M. Dawson, Xingxiang Chen, Wyatt W. Yue, Agnieszka K. Bronowska, Bernadette Carroll, Sascha Martens, Michael Lazarou, Viktor Korolchuk
Summary: Mitophagy is essential for maintaining cellular homeostasis. The best characterised pathway involves the stabilisation of PINK1 and recruitment of Parkin to damaged mitochondria. NDP52 recognises ubiquitinated mitochondrial proteins and initiates autophagic vesicle formation. This study found that oxidation of NDP52 is crucial for efficient PINK1/Parkin-dependent mitophagy, and proposed that redox sensing allows mitophagy to function as an oxidative stress response.
Article
Biochemistry & Molecular Biology
Eric N. Bunker, Francois Le Guerroue, Chunxin Wang, Marie-Paule Strub, Achim Werner, Nico Tjandra, Richard J. Youle
Summary: This study reveals the mechanisms of Nix-mediated mitophagy and the importance of both the LIR and MER regions. The MER region interacts with the autophagy effector WIPI2 and recruits it to mitochondria, while the LIR region converts the distribution of WIPI2 on mitochondria into puncta. These findings provide valuable insights into the process of Nix-induced mitophagy.
Article
Biochemistry & Molecular Biology
Ashari R. Kannangara, Daniel M. Poole, Colten M. McEwan, Joshua C. Youngs, Vajira K. Weerasekara, Alex M. Thornock, Misael T. Lazaro, Eranga R. Balasooriya, Laura M. Oh, Erik J. Soderblom, Jonathan J. Lee, Daniel L. Simmons, Joshua L. Andersen
Summary: ATG9A, a multi-pass transmembrane protein, plays a crucial role in regulating autophagy. It interacts with members of the ULK1 complex and regulators of membrane fusion and vesicle trafficking, marking pathways of ATG9A trafficking through different cellular systems. ATG9A interacts with ATG13-ATG101 independently of ULK1, and deletion of ATG13 or ATG101 causes abnormal accumulation of ATG9A at stalled clusters of certain proteins, which can be rescued by a mutant form of ATG13 lacking ULK1 binding capability.
Article
Biochemistry & Molecular Biology
Cheong-Yong Yun, Nahyun Choi, Jae Un Lee, Eun Jung Lee, Ji Young Kim, Won Jun Choi, Sang Ho Oh, Jong-Hyuk Sung
Summary: This study demonstrated that the marliolide derivative DMF02 can induce melanosome degradation through autophagy pathway by activating Nrf2, leading to reduced melanin pigmentation. Additionally, DMF02 was effective in reducing UVB-induced hyperpigmentation and regulating melanosome degradation via suppression of p62. These findings suggest that Nrf2 activators could be promising therapeutic agents for reducing hyperpigmentation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Jiamei Zhang, Lu Han, Qinmei Ma, Xiaoping Wang, Jialin Yu, Yanan Xu, Xu Zhang, Xiaoling Wu, Guangcun Deng
Summary: It has been found that RIP3 plays a crucial role in fighting against Mycobacterium tuberculosis (M.tb) infection by promoting autophagy, which enhances host clearance of the bacteria.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Yinfeng Xu, Yaosen Wu, Lei Wang, Zhuo Ren, Lijiang Song, Hui Zhang, Chuying Qian, Qian Wang, Zhengfu He, Wei Wan
Summary: The study uncovered a regulatory role of autophagy in RNA metabolism, showing that autophagy-deficient cells have higher levels of 47S precursor rRNA due to accumulation of SQSTM1. This accumulation potentiates MTORC1 signaling, leading to increased rRNA transcription from rDNA and promoting protein synthesis and cell proliferation.
Retraction
Biochemistry & Molecular Biology
A. Caccamo, E. Ferreira, C. Branca, S. Oddo
Summary: The article has been retracted by the Editor-in-Chief and publisher.
MOLECULAR PSYCHIATRY
(2021)
Review
Oncology
Emily E. Hartung, Kanwaldeep Singh, Tobias Berg
Summary: Acute Myeloid Leukemia (AML) is a heterogeneous cancer of the blood system where mutations in myeloid transcription factors and epigenetic regulators contribute to the disease pathogenesis. Inhibition of LSD1, an epigenetic regulator, shows promise in restoring differentiation in AML. The modulation of transcription factor networks by LSD1 inhibition is different between normal and malignant hematopoiesis, offering potential for combination therapies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Ophthalmology
Yasushi Kitaoka, Kana Sase, Chihiro Tsukahara, Naoki Fujita, Ibuki Arizono, Jiro Kogo, Naoto Tokuda, Hitoshi Takagi
Summary: This study investigated the effect of netarsudil on TNF-induced axon loss and found that it increased autophagy and protected against axon degeneration.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Qing Shi, Xiaofeng Jin, Pingzhao Zhang, Qian Li, Zeheng Lv, Yan Ding, Huiying He, Yijun Wang, Yuanlong He, Xiaying Zhao, Shi-Min Zhao, Yao Li, Kun Gao, Chenji Wang
Summary: This study reveals that SPOP mutations induce non-degradative ubiquitination of p62, leading to suppression of p62-dependent autophagy and decreased Nrf2-mediated transcriptional activation of antioxidant genes, thus promoting tumor formation in SPOP-mutated PCa.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Neurosciences
Haifeng Lu, Yugang Wang, Hua Fan, Yiqing Wang, Shenghao Fan, Shimin Hu, Haitao Shen, Haiying Li, Qun Xue, Jianqiang Ni, Qi Fang, Gang Chen
Summary: The mechanisms underlying the regulation of circadian rhythms in relation to the development of brain disorders such as depression, autism, and stroke remain unclear. Glutamate systems and autophagy are thought to play important roles in the pathogenesis of stroke. This study found that GluA1 expression was decreased and autophagic activity was increased during the active phase of stroke in male mouse models. Inhibition of autophagy increased the infarct volume, while activation of autophagy decreased it. Additionally, the circadian rhythm gene Per1 was found to influence GluA1 expression and autophagic activity in stroke.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Cell Biology
Liyan Gong, Kaihua Wang, Mengcheng Wang, Ronggui Hu, Huaguang Li, Daming Gao, Moubin Lin
Summary: The study identified the CUL5-ASB6 complex as a mediator of p62 ubiquitination and degradation, with overexpression of ASB6 inhibiting cell proliferation by reducing p62 protein level and affecting autophagy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Nora Mohamed Elkenawy, Heba Ramadan Ghaiad, Sherehan Mohamed Ibrahim, Ramy Karam Aziz, Eman Rashad, Walaa Ahmed Eraqi
Summary: This study aimed to investigate the radioprotective effects and related mechanisms of ubiquinol against radiation-induced splenic tissue injury. The results showed that ubiquinol can protect the spleen from radiation damage by enhancing antioxidant pathways, promoting autophagy, and enhancing survival pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Xiaolan Fan, Tiantian Huang, Yingdong Tong, Ziqiang Fan, Ziyue Yang, Deying Yang, Xueping Mao, Mingyao Yang
Summary: p62, also known as SQSTM1, is a crucial predictor of autophagic flux and plays a role in maintaining protein homeostasis in cells. It has the ability to resist oxidative stress, and its multiple domains allow it to interact with vital signaling pathways, influencing cell proliferation, apoptosis, and survival. Recent studies have also shown its involvement in the aging process.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Yasukazu Takanezawa, Ryohei Harada, Yoshio Shibagaki, Yui Kashiwano, Ryosuke Nakamura, Yuka Ohshiro, Shimpei Uraguchi, Masako Kiyono
Summary: p62 interacts with NEDD4 to alleviate MeHg toxicity through the formation of a complex.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tzu-Pei Su, Gigin Lin, Yu-Ting Huang, Feng-Yuan Liu, Chun-Chieh Wang, Angel Chao, Hung-Hsueh Chou, Tzu-Chen Yen, Chyong-Huey Lai
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gigin Lin, Yu-Chun Lin, Ren-Chin Wu, Lan-Yan Yang, Hsin-Ying Lu, Shang-Yueh Tsai, Yu-Ting Huang, Yen-Ling Huang, Kuan-Ying Lu, Koon-Kwan Ng, Tzu-Chen Yen, Angel Chao, Chyong-Huey Lai, Ji-Hong Hong
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2018)
Article
Genetics & Heredity
Chiao-Yun Lin, Chia-Lung Tsai, Angel Chao, Li-Yu Lee, Wei-Chun Chen, Yun-Hsin Tang, An-Shine Chao, Chyong-Huey Lai
Summary: Despite recent therapeutic breakthroughs, advanced and/or recurrent endometrial cancer remains a significant health burden globally. Our study suggests that NPM/B23-induced CD24 expression in endometrial cancer cells plays a role in immune evasion by inhibiting macrophage-mediated phagocytosis. CD24 may serve as a novel target for endometrial cancer immunotherapy.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Oncology
Lan-Yan Yang, Tiing Yee Siow, Yu-Chun Lin, Ren-Chin Wu, Hsin-Ying Lu, Hsin-Ju Chiang, Chih-Yi Ho, Yu-Ting Huang, Yen-Ling Huang, Yu-Bin Pan, Angel Chao, Chyong-Huey Lai, Gigin Lin
Summary: Computer-aided segmentation and machine learning using clinical and MR radiomics can predict LN metastasis in EC, with diagnostic performance surpassing conventional ADC and size criteria.
Article
Biochemistry & Molecular Biology
Chiao-Yun Lin, Chun-Chieh Wang, Ren-Chin Wu, Lan-Yan Yang, Chen-Bin Chang, Yu-Bin Pan, Angel Chao, Chyong-Huey Lai
Summary: The study identified that miR143-3p targeting BIRC2 may affect tumor recurrence and treatment response in alpha 7-HPV-related cervical SCC. High BIRC2 expression was associated with poor prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Feng-Yuan Liu, Gigin Lin, Jing-Ren Tseng, Angel Chao, Huei-Jean Huang, Hung-Hsueh Chou, Yu-Chen Chang, Tzu-Chen Yen, Chyong-Huey Lai
Summary: Heterogeneity assessment using first-order and texture analysis metrics in F-18-fluorodeoxyglucose PET imaging was evaluated for classification of metastatic and benign bone lesions in cervical cancer patients. SUVsd was found to be superior to SUVmax in classification, but careful validation is required for multiple features and parameters in texture analysis.
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2021)
Review
Genetics & Heredity
Yun-Hsin Tang, Chiao-Yun Lin, Chyong-Huey Lai
Summary: The Cancer Genome Atlas research network has provided molecular classifications for gynecologic cancers with the use of NGS technology, impacting clinical practice. New cancer treatments targeting pathogenic gene abnormalities, particularly PARP inhibitors, have shown breakthrough benefits in reducing hazard ratios for BRCA1/2 mutated ovarian cancer. Immune checkpoint inhibition also shows promise in cancers with mismatch repair deficiency or microsatellite instability.
Article
Oncology
Chiao-Yun Lin, Ren-Chin Wu, Chen-Yang Huang, Chyong-Huey Lai, An-Shine Chao, Hsin-Pai Li, Chia-Lung Tsai, Elizabeth Joo-Wen Kuek, Cheng-Lung Hsu, Angel Chao
Summary: Reliable animal models are crucial for studying novel treatment approaches in human malignancies. A patient-derived xenograft model termed PDX-mLung was developed for dedifferentiated endometrial carcinoma, showing high similarity and druggable genetic alterations. Combination treatment with FGFR inhibitor and cell cycle inhibitor exhibited synergistic therapeutic effects in vivo, highlighting the potential of molecularly informed therapies in difficult-to-treat cancers.
Article
Medicine, General & Internal
Yenpo Lin, Ching-Yi Hsieh, Yen-Ling Huang, Kueian Chen, Yu-Ting Huang, Ren-Chin Wu, Huei-Jean Huang, Hung-Hsueh Chou, Angel Chao, Chyong-Huey Lai, Gigin Lin
Summary: The study aimed to assess the additional value of DWI and MRS for risk stratification of sonographically indeterminate ovarian neoplasms. The results showed that MRS could play an important role in the differential diagnosis of ovarian tumors, especially for O-RADS 4 lesions or clear cell carcinomas.
Article
Medicine, General & Internal
Pei-Ching Huang, Ren-Chin Wu, Yu-Hsiang Juan, Hui-Yu Ho, Yung-Chang Lin, Yi-Ting Huang, Shu-Hang Ng, Chyong-Huey Lai, Angel Chao, Gigin Lin
Summary: This study retrospectively investigated the imaging characteristics and diagnostic accuracy of whole-body computed tomography (WBCT) for incidental ovarian tumors in breast cancer patients. The results showed that WBCT can accurately diagnose these ovarian tumors and guide disease management.
Article
Health Care Sciences & Services
Hao-Chien Hung, Po-Jung Hsu, Ting-Chang Chang, Hung-Hsueh Chou, Kuan-Gen Huang, Chyong-Huey Lai, Chao-Wei Lee, Ming-Chin Yu, Jeng-Fu You, Yu-Jen Hsu, Jun-Te Hsu, Ting-Jung Wu
Summary: This study analyzed 132 patients undergoing CRS-HIPEC and found that patients in the MDT group had higher PCI scores and more complete CRS than those in the non-MDT group, with similar post-operative complication rates. Independent prognostic factors for survival included older age, ECOG score, and completeness of cytoreduction.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Hsiu-Jung Tung, Ren-Chin Wu, Chiao-Yun Lin, Chyong-Huey Lai
Summary: Endometrial cancer is one of the most common gynecologic cancers worldwide, with increasing incidence rates. The latest molecular classifications have identified different subtypes, but undifferentiated/dedifferentiated EC has not been mentioned. This rare and aggressive type of cancer is resistant to conventional chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hsien-Ming Wu, Liang-Hsuan Chen, Le-Tien Hsu, Chyong-Huey Lai
Summary: Embryo-endometrial communication plays a critical role in successful embryo implantation and pregnancy establishment through the regulation of maternal immune responses. Recent research has highlighted the importance of extracellular vesicles (EVs) and microRNAs in this process, showing that they modulate maternal immune responses and promote cross-communication between the embryo and the endometrium. Exploring the functions and mechanisms of EVs in embryo implantation and pregnancy may provide valuable insights for reproductive medicine and infertility treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Takayuki Enomoto, Aikou Okamoto, Jae-Hoon Kim, Chyong-Huey Lai, Xiaohua Wu, Yong-Man Kim
Summary: There are racial and regional differences in gynecologic cancer, but most large-scale phase III studies have been conducted in Western countries, limiting data on Asians. To address this, four clinical trial groups in East Asia have established the East Asia Gynecologic Oncology Trial Group (EAGOT) to conduct international clinical trials and provide the best treatments for Asian women. EAGOT aims to establish standards of care and guidelines for gynecologic cancer in Asia.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Chyong-Huey Lai, Elizabeth Vallikad, Hao Lin, Lan-Yan Yang, Shih-Ming Jung, Hsueh-Erh Liu, Yu-Che Ou, Hung-Hsueh Chou, Cheng-Tao Lin, Huei-Jean Huang, Kuan-Gen Huang, Jiantai Qiu, Yao-Ching Hung, Tzu- Wu, Wei-Yang Chang, Kien-Thiam Tan, Chiao-Yun Lin, Angel Chao, Chee-Jen Chang
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2020)